Neural Plasticity in Human Brain Connectivity: The Effects of Long Term Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease

Hartevelt, Tim J. van; Cabral, Joana; Møller, Arne; Green, Alexander L.; Aziz, Tipu Z.; Kringelbach, Morten L.

doi:10.1371/journal.pone.0086496

Cited by 104 publications

(97 citation statements)

References 56 publications

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“…We first modelled structural changes in these patients using whole-brain computational models 73 , and observed an improvement in the performance of the model compared to that of normal participants following six months of DBS of the subthalamic nucleus (Figure 4A and 4B). As shown in Figure 4C, the perturbational measures of segregation and integration were sensitive to the improvements (that is, alleviation of symptoms) following DBS.…”

Section: Characterizing Different States Of the Brain In Health And Dmentioning

confidence: 99%

Rethinking segregation and integration: contributions of whole-brain modelling

et al. 2015

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The brain regulates information flow by balancing the segregation and integration of incoming stimuli to facilitate flexible cognition and behaviour. Topological features of brain networks, in particular network communities and hubs, support this segregation and integration but do not provide information regarding how external inputs are processed dynamically (i.e. over time). Experiments in which the consequences of selective inputs on brain activity are controlled and traced with great precision could provide such information. However, such strategies have thus far had limited success. By contrast, recent whole-brain computational modelling approaches have enabled us to start assessing the effect of input perturbations on brain dynamics in silico. IntroductionEvolution has developed many different strategies for the survival of species. The relative evolutionary success of mammals has been made possible by sophisticated brains that can combine current stimuli with past memories to predict the future and to adapt behaviour accordingly. The healthy human brain is very good at segregating and integrating information from different sensory modalities, which is combined with memory traces and with information about the current state of the brain and body to guide predictions and decision-making processes needed for adaptive behaviour. Take the example of a tennis player who effortless can integrate the colour, movement and shape of a tennis ball whilst segregating this object from the changing background of the tennis court and crowd, while she is predicting its trajectory and planning how best to position her tennis racket to return the ball beyond her opponent's reach. The integrated information can be formally defined as the information possessed by a system which is above and beyond the information that is available from the sum of its parts 1, 2 . Such information integration has been linked to

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Section: Characterizing Different States Of the Brain In Health And Dmentioning

confidence: 99%

Rethinking segregation and integration: contributions of whole-brain modelling

et al. 2015

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“…Deep-brain stimulation (DBS) is a powerful clinical therapeutic tool of neuromodulation that has recently emerged as a new focus of functional neuroimaging investigations (Kahan et al, 2014;van Hartevelt et al, 2014). Neuroimaging studies with DBS in animals have focused on neurological conditions, such as epilepsy (Canals et al, 2008;Dunn et al, 2009;Jupp et al, 2006) and Parkinson's disease Lai et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Brainstem Stimulation Increases Functional Connectivity of Basal Forebrain-Paralimbic Network in Isoflurane-Anesthetized Rats

et al. 2014

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Brain states and cognitive-behavioral functions are precisely controlled by subcortical neuromodulatory networks. Manipulating key components of the ascending arousal system (AAS), via deep-brain stimulation, may help facilitate global arousal in anesthetized animals. Here we test the hypothesis that electrical stimulation of the oral part of the pontine reticular nucleus (PnO) under light isoflurane anesthesia, associated with loss of consciousness, leads to cortical desynchronization and specific changes in blood-oxygenation-level-dependent (BOLD) functional connectivity (FC) of the brain. BOLD signals were acquired simultaneously with frontal epidural electroencephalogram before and after PnO stimulation. Whole-brain FC was mapped using correlation analysis with seeds in major centers of the AAS. PnO stimulation produced cortical desynchronization, a decrease in d-and h-band power, and an increase in approximate entropy. Significant increases in FC after PnO stimulation occurred between the left nucleus Basalis of Meynert (NBM) as seed and numerous regions of the paralimbic network. Smaller increases in FC were present between the central medial thalamic nucleus and retrosplenium seeds and the left caudate putamen and NBM. The results suggest that, during light anesthesia, PnO stimulation preferentially modulates basal forebrain-paralimbic networks. We speculate that this may be a reflection of disconnected awareness.

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Section: Deep Brain Stimulationmentioning

confidence: 99%

“…The long -term DBS was found to restore local brain structural connectivity and global functional connectivity (eg, Parkinson disease). 99 The first clinical evidence that demonstrated an effective BP reduction after DBS was reported in a patient who primarily underwent a stimulation of the ventrolateral PAG/periventricular gray matter to treat his chronic central pain syndrome that was unresponsive to pain--relief drug.100 While DBS alleviated pain levels for 4 months which then returned to the same level as before the procedure, there was a gradual decrease in BP up to 33 months after DBS with medication withdrawal postoperatively. These results indicated that the site in the brain (PAG) can be a target for sympathetic BP control and center for pain modulation.…”

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confidence: 99%

Recent advances in the pathophysiology of arterial hypertension - potential implications for clinical practice

Hering¹,

Trzebski²

2017

Polish Archives of Internal Medicine

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REVIEW ARTICLE Advances in pathophysiology of arterial hypertension 195 population. Notably, only 46.5% of participants were aware of their hypertension, with less than half (40.6%) medically treated and BP levels less than 140/90 mm Hg achieved in 1 in 3 individuals (13.2%).1 The global disparities in the prevalence, awareness, treatment, and control of hypertension have also been indicated in a recent meta -analysis of 135 population -based studies from 90 countries.2 Globally, the number of individuals with hypertension increased, reaching an estimated total of 1.39 billion adults with hypertension, including 349 million in high -income countries and 1.04 billion in low-and middle -income countries by 2010. The increased and highest prevalence of raised BP has been particularly noted in East Europe, Asia, Africa, and Latin America. 2 Introduction Despite the well -recognized benefits of reducing major cardiovascular events and mortality through the control of blood pressure (BP), detection rates and control of hypertension remain low across all countries. Even though therapy is initiated in the vast majority of patients diagnosed with hypertension, treatment is suboptimal with a declined use of antihypertensive drugs over time. A large gap between the prevalence, awareness, treatment, and control of hypertension has been addressed in the multinational Prospective Urban Rural Epidemiology (PURE) study conducted in 628 communities, including high -income, upper -middle -income, low -middle -income and low -income countries. KEY WORDShypertension, interventional therapies, neural reflexes, neuroplasticity, sympathetic nervous system ABSTRACT Hypertension remains a major and growing public health problem associated with the greatest global rate of cardiovascular morbidity and mortality. Although numerous factors contribute to poor control of blood pressure (BP) and to pseudo resistance (eg, unawareness, lifestyle habits, nonadherence to medication, insufficient treatment, drug -induced hypertension, undiagnosed secondary causes), true resistant hypertension (RH) is reported in 10.1% of patients treated for elevated BP. While the mechanisms underlying RH remain complex and not entirely understood, sympathetic activation involved in the pathophysiology of hypertension, disease progression, and adverse complications is further augmented in patients with drug -resistant hypertension. The well -established contribution of neurogenic component of hypertension has led to the introduction of new alternative therapies aimed specifically at modulating central and neural reflexes mechanisms involved in BP control. Although clinical benefits of lowering BP with renal denervation, baroreflex activation therapy, carotid body denervation, central arteriovenous anastomosis, and deep brain stimulation have advanced our knowledge on uncontrolled hypertension, the variable BP response has prompted extensive ongoing research to define predictors of treatment effectiveness and further investigation of pathophysiology of RH. Very rec...

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Neural Plasticity in Human Brain Connectivity: The Effects of Long Term Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson’s Disease

Cited by 104 publications

References 56 publications

Rethinking segregation and integration: contributions of whole-brain modelling

Rethinking segregation and integration: contributions of whole-brain modelling

Brainstem Stimulation Increases Functional Connectivity of Basal Forebrain-Paralimbic Network in Isoflurane-Anesthetized Rats

Recent advances in the pathophysiology of arterial hypertension - potential implications for clinical practice

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