Neural oscillations as a bridge between glutamatergic system and emotional behaviors in simulated microgravity-induced mice

Shang, Xueliang; Xu, Bo; Li, Qun; Zhai, Baohui; Xu, Xinfang; Zhang, Tao

doi:10.1016/j.bbr.2016.09.063

Cited by 26 publications

(4 citation statements)

References 24 publications

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“…This model results in a cephalad fluid shift and avoids weight-bearing for the hindquarters. From cardiovascular, muscular, and hormonal points of view, this condition has been considered to be very similar to microgravity in space [ 24 ]. Based on this, lots of research were carried out [ 25 – 28 ].…”

Section: Discussionmentioning

confidence: 99%

Involvement of Cholinergic Dysfunction and Oxidative Damage in the Effects of Simulated Weightlessness on Learning and Memory in Rats

Zhang

Wang

Chen

et al. 2018

BioMed Research International

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The present study aimed to determine how the learning and memory gradually change with the prolonged hindlimb unloading (HU) treatment in rats. Different HU durations (7 d, 14 d, 21 d, and 28 d) in Sprague-Dawley (SD) rats were implemented. Cognitive function was assessed using the Morris water maze (MWM) and the shuttle box test. Additionally, parameters about cholinergic activity and oxidative stress were tested. Results showed that longer-than-14 d HU led to the inferior performances in the behavioral tasks. Besides, acetylcholine esterase (AChE) activity, malondialdehyde (MDA) level in brain, reactive oxygen species (ROS), and 8-hydroxy-2-deoxyguanosine (8-OHdG) concentrations of HU rats were significantly increased. Furthermore, choline acetyltransferase (ChAT), superoxide dismutase (SOD), and catalase (CAT) activity in brain were notably attenuated. Most of these effects were more pronounced after longer exposure (21 d and 28 d) to HU, although some indicators had their own characteristics of change. These results indicate that cholinergic dysfunction and oxidative damage were involved in the learning and memory impairments induced by longer-than-14 d HU. Moreover, the negative effects of HU tend to be augmented as the HU duration becomes longer. The results may be helpful to present possible biochemical targets for countermeasures development regarding the memory deficits under extreme environmental conditions.

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Section: Discussionmentioning

confidence: 99%

Involvement of Cholinergic Dysfunction and Oxidative Damage in the Effects of Simulated Weightlessness on Learning and Memory in Rats

Zhang

Wang

Chen

et al. 2018

BioMed Research International

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“…Each oscillation has its particular physiological function. Recently, many studies showed that the coupling between different frequencies represented a specific physiological process, such as learning and memory, emotion and social behavior [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Enriched environment and social isolation affect cognition ability via altering excitatory and inhibitory synaptic density in mice hippocampus

Wang

Gao

et al. 2020

Preprint

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Background The purpose of the study was to examine whether the underlying mechanism of the alteration of cognitive ability and synaptic plasticity induced by the housing environment is associated with the balance of excitatory/inhibitory synaptic density. Enriched environment (EE) and social isolation (SI) are two different housing environment, and one is to give multiple sensory environments, the other is to give monotonous and lonely environment. Results Male four-week-old C57 mice were divided into three groups: CON, EE and SI. They were housed in the different cage for 3 months. Morris water maze (MWM) and novel object recognition were performed. Long term potentiation (LTP), depotentiation (DEP) and Local field potential (LFPs) were recorded in the hippocampal perforant pathway (PP) and dentate gyrus (DG). The data showed that EE enhanced the ability of spatial learning, reversal learning and memory as well as LTP/DEP in the hippocampal DG region. Meanwhile, SI reduced those abilities and the level of LTP/DEP. Moreover, there were higher couplings of both phase-amplitude and phase-phase in the EE group, and lower couplings of them in the SI group compared to that in the CON group. Western blot analysis showed that EE significantly enhanced the level of PSD-95, NR2B; however, SI reduced them but enhanced level of GABAAR. Conclusion These date suggests that the cognitive functions, synaptic plasticity and neural oscillatory patterns were significantly impacted by housing environment via possibly changing the balance of excitatory and inhibitory synaptic density.

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“…These results are consistent with several recent studies demonstrating that the frequency, but not amplitude, of sIPSCs recorded in the CA1 PNs of young AD transgenic mice was decreased 13,37,38 and are also consistent with the idea that neuronal E/I imbalance is an early pathological sign of AD 36 . Note that emotional disturbances, such as heightened anxiety, that result from impaired neuronal E/I balance are linked to altered hippocampal oscillations, which have also been recognized as an early marker of AD 39 . Consistently, our data with in vivo electrophysiological recording indicated that the powers of neural oscillations in the theta, beta, and gamma frequency ranges were decreased in the vCA1 of young adult PS cDKO mice (Fig.…”

Section: Discussionmentioning

confidence: 99%

Kv1.1 channel dysfunction in parvalbumin-positive interneurons contributes to anxiety-like behaviors in young adult presenilin 1/2 conditional double knockout mice

Yang²,

Zhao³

et al. 2023

Preprint

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Anxiety, as an early manifestation of Alzheimer’s disease (AD), plays a significant role in the initial stages of cognitive decline and has a negative impact on the progression of the disease. However, the specific pathological mechanisms underlying anxiety in early stage of AD remain largely unknown. In this study, we investigated anxiety-like behaviors in presenilin 1/2 conditional double knockout (PS cDKO) mice, which are commonly used to study AD. To characterize anxiety-like behaviors, we conducted a battery of behavioral tests on young adult PS cDKO mice. Additionally, we performed electrophysiological recordings to examine the balance of excitatory and inhibitory activity in the synapses of pyramidal neurons and the neural network oscillations in the ventral hippocampus (vHPC) CA1 (vCA1) region of PS cDKO mice displaying anxiety-like behaviors. Our findings revealed a shift in the normal excitatory/inhibitory (E/I) balance and neural oscillations in the vCA1 region of PS cDKO mice with anxiety-like behaviors. Furthermore, we observed that parvalbumin-positive (PV+) interneurons, which play a crucial role in regulating the balance of excitatory and inhibitory activity, exhibited hypoexcitability in the vCA1 of PS cDKO mice. Mechanistically, we identified increased levels of Kv1.1, a voltage-gated potassium channel, in the vCA1 PV+ interneurons of PS cDKO mice. Genetically or pharmacologically, when we inhibited Kv1.1 in the vCA1 region, the hypoexcitability of PV+ interneurons was reversed and anxiety-like behaviors in PS cDKO mice were rescued. Therefore, we propose that the increased Kv1.1 levels in vCA1 PV+ interneurons reduce the excitability of PV+ interneurons, ensuing disrupted E/I balance of pyramidal neuron synapses causes anxiety in young adult PS cDKO mice. These findings provide new insights into the mechanisms underlying early AD-related anxiety-like behaviors.

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Neural oscillations as a bridge between glutamatergic system and emotional behaviors in simulated microgravity-induced mice

Cited by 26 publications

References 24 publications

Involvement of Cholinergic Dysfunction and Oxidative Damage in the Effects of Simulated Weightlessness on Learning and Memory in Rats

Involvement of Cholinergic Dysfunction and Oxidative Damage in the Effects of Simulated Weightlessness on Learning and Memory in Rats

Enriched environment and social isolation affect cognition ability via altering excitatory and inhibitory synaptic density in mice hippocampus

Kv1.1 channel dysfunction in parvalbumin-positive interneurons contributes to anxiety-like behaviors in young adult presenilin 1/2 conditional double knockout mice

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