“…In the past years, various computer-aided approaches based on image processing methods have been presented to classify five types of mature WBCs (Neutrophils, Eosinophils, Basophils, Lymphocytes and Monocytes) (Sarrafzadeh et al, 2014[ 29 ]; Habibzadeh et al, 2012[ 12 ]; Putzu et al, 2014[ 21 ]) six types of immature WBCs (CML cells; Myeloblast, Promyelocyte, Myelocyte, Metamyelocyte, Band and Neutrophil) (Theera-Umpon and Dhompongsa, 2007[ 33 ]; Ramirez-Cortes et al, 2010[ 22 ]; Theera-Umpon, 2005[ 32 ]) plasma cells in myeloma (Saeedizadeh et al, 2016[ 28 ]) and effective cells in diagnosis other leukemia (CLL (Alférez et al, 2014[ 3 ]), AML and ALL (Laosai and Chamnongthai, 2014[ 15 ]; MoradiAmin et al, 2016[ 19 ])).…”