The hybrid model, consisting of a 21-parameter health screening and a 3-tier evaluation of cardiac recovery, was the best predictor of outcome, predicting 90% true weans, 100% true transplants, 0% false weans and 10% false transplants. By objectively combing knowledge from experts and data, this study illustrates how a CDSS can facilitate the decision making processes for identifying VAD weaning candidates and promote responsible and widespread use of VADs for cardiac rehabilitation.iv