Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis

Catavero, Christina M.; Bao, Hechen; Song, Juan

doi:10.1007/s00441-017-2668-y

Cited by 70 publications

(49 citation statements)

References 146 publications

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“…In the adult hippocampus SGZ neurogenic niche of radial-like glial cells maintains quiescence by tonic GABA release from interneurons. Once interneurons differentiate into neural progenitor cells, GABA continues to regulate their development into mature granule cells ( Jin et al., 2001 ; Tozuka et al., 2005 ; Coulter and Carlson, 2007 ; Houser, 2007 ; Kim et al., 2012 ; Catavero et al., 2018 ). As clino2 cells have detectable levels of GABA and the EC plexus immunolabels with GABA A R we hypothesize that similar signaling mechanisms may contribute to proliferation of clinocytes and differentiation into clino2 cells in the EC ( Figure 11 ).…”

Section: Discussionmentioning

confidence: 99%

Developmental GAD2 Expression Reveals Progenitor-like Cells with Calcium Waves in Mammalian Crista Ampullaris

2020

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Summary Sense of motion, spatial orientation, and balance in vertebrates relies on sensory hair cells in the inner ear vestibular system. Vestibular supporting cells can regenerate hair cells that are lost from aging, ototoxicity, and trauma, although not all factors or specific cell types are known. Here we report a population of GAD2-positive cells in the mouse crista ampullaris and trace GAD2 progenitor-like cells that express pluripotent transcription factors SOX2, PROX1, and CTBP2. GAD2 progenitor-like cells organize into rosettes around a central branched structure in the eminentia cruciatum (EC) herein named the EC plexus. GCaMP5G calcium indicator shows spontaneous and acetylcholine-evoked whole-cell calcium waves in neonatal and adult mice. We present a hypothetical model that outlines the lineage and potential regenerative capacity of GAD2 cells in the mammalian vestibular neuroepithelium.

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Section: Discussionmentioning

confidence: 99%

Developmental GAD2 Expression Reveals Progenitor-like Cells with Calcium Waves in Mammalian Crista Ampullaris

2020

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“…Indeed, the glutamic acid decarboxylase isoforms (Gad1 and Gad2), which regulate GABA synthesis from the excitatory neurotransmitter glutamate and whose expression is activated by DLX1 and/or DLX2 (Stühmer et al, 2002a , b ; Le et al, 2017 ), share numerous pentapeptides with the 25 viral proteomes (see Supplementary Table 1 ). Hence, a scenario emerges where immune responses following infections might cause a cascade of multiple crossreactions at multiple levels (i.e., DLX, GAD) of the intracellular mechanisms regulating the function of GABAergic neurons and altering the excitation and inhibition ratio, which is necessary for normal neural circuit function and whose imbalance contributes to neurodevelopmental diseases (Kang, 2017 ; Maffei et al, 2017 ; Ye and Kaszuba, 2017 ; Catavero et al, 2018 ; Garret et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

Peptide Sharing Between Viruses and DLX Proteins: A Potential Cross-Reactivity Pathway to Neuropsychiatric Disorders

Lucchese

Stahl

2018

Front. Neurosci.

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The present study seeks to determine potential associations between viral infections and neuropsychiatric diseases. To address this issue, we investigated the peptide commonalities between viruses that have been related to psychiatric and neurological disorders—such as rubella, human immunodeficiency virus, and herpesviruses—and human distal-less homeobox (DLX) proteins expressed in developing brain—namely, DLX1, DLX2, DLX5, and DLX6. Peptide matching analyses revealed a high degree of pentapeptide sharing. From an immunological perspective, this overlap is relevant because pentapeptides are endowed with immunogenicity and antigenicity—that is, they are immune determinants. Moreover, infection-induced immune cross-reactions might have functional, spatial, and temporal implications related to the functions and expression patterns of DLX1 and DLX5 in the fetal and adult human brain. In sum, our data support the hypothesis that viral infections may be linked to neuropsychiatric diseases through autoimmune cross-reactions caused by molecular mimicry between viral proteins and brain-specific DLX self-antigens.

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“…Many growth factors, signaling molecules, and neurotransmitters have been shown to regulate neurogenesis (Kempermann, Song and Gage, 2015). Catavero et al [in this issue (Catavero, et al, 2018)] review the role of GABA circuits, signaling, and receptors in regulating development of adult born cells, as well as the molecular players that modulate GABA signaling. Because progenitors with multipotent differentiation potentials have been found in brain regions without active neurogenesis (Palmer, et al, 1997), it is hypothesized that these progenitors might be manipulated to become neuron-competent in vivo so that they can contribute to brain generation [Wang et al, in this issue (Wang and Zhang, 2018)].…”

Section: Nscs In the Adult Brainmentioning

confidence: 99%

Neural stem cells: developmental mechanisms and disease modeling

Zhao

Moore

2017

Cell Tissue Res

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Summary The astonishing progress in the field of stem cell biology during the past 40 years has transformed both science and medicine. Neural stem cells (NSCs) are the stem cells of the nervous system. During development they give rise to the entire nervous system. In adults, a small number of NSCs remain and are mostly quiescent; however, ample evidence supports their important roles in plasticity, aging, disease, and regeneration of the nervous system. Because NSCs are regulated by both intrinsic genetic and epigenetic programs and extrinsic stimuli transduced through the stem cell niche, dysregulation of NSCs due to either genetic causes or environmental impacts may lead to disease. Therefore, extensive investigations in the past decades have been devoted to understanding how NSCs are regulated. On the other hand, ever since their discovery, NSCs have been a focal point for cell-based therapeutic strategies in the brain and spinal cord. The limited number of NSCs residing in the tissue has been a limiting factor for their clinical applications. Although recent advancements in embryonic and induced pluripotent stem cells have provided novel sources for NSCs, several challenges remain. In this special issue, leaders and experts in NSCs summarize our current understanding of NSC molecular regulation and the importance of NSCs for disease modeling and translational applications.

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Neural mechanisms underlying GABAergic regulation of adult hippocampal neurogenesis

Cited by 70 publications

References 146 publications

Developmental GAD2 Expression Reveals Progenitor-like Cells with Calcium Waves in Mammalian Crista Ampullaris

Developmental GAD2 Expression Reveals Progenitor-like Cells with Calcium Waves in Mammalian Crista Ampullaris

Peptide Sharing Between Viruses and DLX Proteins: A Potential Cross-Reactivity Pathway to Neuropsychiatric Disorders

Neural stem cells: developmental mechanisms and disease modeling

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