Neural mechanisms of attentional bias to emotional faces in patients with chronic insomnia disorder

Zhao, Guangli; Yu, Liyong; Chen, Peixin; Zhu, Keli; Yang, Lu; Lin, Wenting; Luo, Yucai; Dou, Zeyang; Xu, Hao; Zhang, Pan; Zhu, Tianmin; Yu, Siyi

doi:10.1016/j.jpsychires.2023.11.008

Journal of Psychiatric Research

2024

DOI: 10.1016/j.jpsychires.2023.11.008

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Neural mechanisms of attentional bias to emotional faces in patients with chronic insomnia disorder

Guangli Zhao,

Liyong Yu,

Peixin Chen

et al.

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2024

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Transcriptional signatures of cortical structural changes in chronic insomnia disorder

Yu,

Hu,

Luo

et al. 2024

Psychophysiology

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Chronic insomnia disorder (CID) is a multidimensional disease that may influence various levels of brain organization, spanning the macroscopic structural connectome to microscopic gene expression. However, the connection between genomic variations and morphological alterations in CID remains unclear. Here, we investigated brain structural changes in CID patients at the whole‐brain level and whether these link to transcriptional characteristics. Brain structural data from 104 CID patients and 102 matched healthy controls (HC) were acquired to examine cortical structural alterations using morphometric similarity (MS) analysis. Partial least squares (PLS) regression and transcriptome data from the Allen Human Brain Atlas were used to extract genomes related to MS changes. Gene‐category enrichment analysis (GCEA) was used to identify potential molecular mechanisms behind the observed structural changes. We found that CID patients exhibited MS reductions in the parietal and limbic regions, along with enhancements in the temporal and frontal regions compared to HCs (pFDR < .05). Subsequently, PLS and GCEA revealed that these MS alterations were spatially correlated with a set of genes, especially those significantly correlated with excitatory and inhibitory neurons and chronic neuroinflammation. This neuroimaging‐transcriptomic study bridges the gap between cortical structural changes and the molecular mechanisms in CID patients, providing novel insight into the pathophysiology of insomnia and targeted treatments.

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Transcriptional signatures of cortical structural changes in chronic insomnia disorder

Yu,

Hu,

Luo

et al. 2024

Psychophysiology

View full text Add to dashboard Cite

show abstract

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Neural mechanisms of attentional bias to emotional faces in patients with chronic insomnia disorder

Cited by 1 publication

References 68 publications

Transcriptional signatures of cortical structural changes in chronic insomnia disorder

Transcriptional signatures of cortical structural changes in chronic insomnia disorder

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