Neural mechanisms for the functional coupling of autonomic, endocrine and somatomotor responses in adaptive behavior

Swanson, L. W.; Mogenson, Gordon J.

doi:10.1016/0165-0173(81)90010-2

Cited by 237 publications

(87 citation statements)

References 148 publications

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“…From a functional aspect, the VMH is involved heavily in the integration of forebrain neural influences with ascending information from the brainstem, and distributing the resulting output to regions involved in the control of visceral and behavioral mechanisms (Swanson and Mogenson, 1981). Functions associated with the VMH include the control of pituitary hormone release (Blache et al, 1991;Chateau et al, 1984;Kato et al, 1983;Okada et al, 1991;Pan and Gala, 1985).…”

Section: From a Neuroendocrine Aspect It Is Interesting To Note Thatmentioning

confidence: 99%

Distribution of type 1 cannabinoid receptor‐expressing neurons in the septal‐hypothalamic region of the mouse: Colocalization with GABAergic and glutamatergic markers

Hrabovszky

Wittmann

Kalló

et al. 2012

J of Comparative Neurology

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Type 1 cannabinoid receptor (CB1) is the principal mediator of retrograde endocannabinoid signaling in the brain. In this study, we addressed the topographic distribution and amino acid neurotransmitter phenotype of endocannabinoid‐sensitive hypothalamic neurons in mice. The in situ hybridization detection of CB1 mRNA revealed high levels of expression in the medial septum (MS) and the diagonal band of Broca (DBB), moderate levels in the preoptic area and the hypothalamic lateroanterior (LA), paraventricular (Pa), ventromedial (VMH), lateral mammillary (LM), and ventral premammillary (PMV) nuclei, and low levels in many other hypothalamic regions including the suprachiasmatic (SCh) and arcuate (Arc) nuclei. This regional distribution pattern was compared with location of γ‐aminobutyric acid (GABA)ergic and glutamatergic cell groups, as identified by the expression of glutamic acid decarboxylase 65 (GAD65) and type 2 vesicular glutamate transporter (VGLUT2) mRNAs, respectively. The MS, DBB, and preoptic area showed overlaps between GABAergic and CB1‐expressing neurons, whereas hypothalamic sites with moderate CB1 signals, including the LA, Pa, VMH, LM, and PMV, were dominated by glutamatergic neurons. Low CB1 mRNA levels were also present in other glutamatergic and GABAergic regions. Dual‐label in situ hybridization experiments confirmed the cellular co‐expression of CB1 with both glutamatergic and GABAergic markers. In this report we provide a detailed anatomical map of hypothalamic glutamatergic and GABAergic systems whose neurotransmitter release is controlled by retrograde endocannabinoid signaling from hypothalamic and extrahypothalamic target neurons. This neuroanatomical information contributes to an understanding of the role that the endocannabinoid system plays in the regulation of endocrine and metabolic functions. J. Comp. Neurol. 520:1005–1020, 2012. © 2011 Wiley Periodicals, Inc.

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Section: From a Neuroendocrine Aspect It Is Interesting To Note Thatmentioning

confidence: 99%

Distribution of type 1 cannabinoid receptor‐expressing neurons in the septal‐hypothalamic region of the mouse: Colocalization with GABAergic and glutamatergic markers

Hrabovszky

Wittmann

Kalló

et al. 2012

J of Comparative Neurology

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“…In particular, the mPOA receives, directly or indirectly, inputs from most if not all sensory modalities and is therefore ideally organized to integrate information from the environment and adjust responses made by the organism to environmental inputs [43,44,80,94,100,123,126,130,135]. The mPOA, in general, is a key center controlling many autonomic functions (e.g.…”

Section: The Preoptic Area As An Integration Center For the Control Omentioning

confidence: 99%

Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

Balthazart

Ball

2007

Frontiers in Neuroendocrinology

189

168

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Several studies have suggested dissociations between neural circuits underlying the expression of appetitive (i.e. sexual motivation) and consummatory components (i.e., copulatory behavior) of vertebrate male sexual behavior. The medial preoptic area (mPOA) clearly controls the expression of male copulation but, according to a number of experiments, is not necessarily implicated in the expression of appetitive sexual behavior. In rats for example, lesions to the mPOA eliminate maletypical copulatory behavior but have more subtle or no obvious effects on measures of sexual motivation. Rats with such lesions still pursue and attempt to mount females. They also acquire and perform learned instrumental responses to gain access to females. However, recent lesions studies and measures of the expression of the immediate early gene c-fos demonstrate that, in quail, subregions of the mPOA, in particular of its sexually dimorphic component the medial preoptic nucleus, can be specifically linked with either the expression of appetitive or consummatory sexual behavior. In particular more rostral regions can be linked to appetitive components while more caudal regions are involved in consummatory behavior. This functional sub-region variation is associated with neurochemical and hodological specializations (i.e. differences in chemical phenotype of the cells or in their connectivity), especially those related to the actions of androgens in relation to the activation of male sexual behavior, that are also present in rodents and other species. It could thus reflect general principles about POA organization and function in the vertebrate brain.

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“…functions of MPO MPO has been implicated in a variety of physiological and behavioral functions, including maternal and sex behaviors (Clemens and Gladue, 1979;Jacobson et al, 1980;Swanson and Mogenson, 1981;McCarthy et al, 1990;Mallick et al, 1994) sleep (McGinty and Szymusiak, 1990;Koyama and Hayaishi, 1994;Lin et al, 1994), thermoregulation and maintenance of water balance (Roberts and Martin, 1977;Swanson et al, 1978;Day et al, 1979;Swanson and Mogenson, 1981;Hori et al, 1988;Scammell et al, 1993;Vellucci and Parrott, 1994), antinociception (Carstens et al, 1982), and autonomic regulation (Wang and Ranson, 1941;Mancia and Zanchetti, 1981;Swanson and Mogenson, 1981;Manning et al, 1985;O'Neill and Brody, 1987;Hori et al, 1988). MPO plays a gender-dependent role in reproductive behavior.…”

Section: Reproductivementioning

confidence: 99%

Medial preoptic area afferents to periaqueductal gray medullo-output neurons: a combined Fos and tract tracing study

et al. 1996

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We have shown recently that the medial preoptic area (MPO) robustly innervates discrete columns along the rostrocaudal axis of the midbrain periaqueductal gray (PAG). However, the location of PAG neurons responsive to MPO activation is not known. Anterograde tract tracing was used in combination with Fos immunohistochemistry to characterize the MPO -+ PAG pathway anatomically and ,functionally within the same animal. Focal electrical or chemical stimulation of MPO in anesthetized rats induced extensive Fos expression within the PAG compared with sham controls. Fos-positive neurons were organized as 2-3 longitudinal columns. The organization and location of these columns overlapped remarkably well with the distribution of fibers and terminals in PAG labeled by Phaseolus vulgaris leucoagglutinin (PHA-L) injected into the same MPO stimulation site. This indicates that MPO inputs may terminate on the soma or proximal dendrites of neurons exhibiting elevated Fos. A second series of experiments investigated whether MPO stimulation excited PAG neurons with descending projections to the medulla. Retrograde labeling of PAG neurons projecting to the medial and lateral regions of the rostroventral medulla (RVM) was combined with MPO-induced Fos expression. The results showed that a substantial population (3743%)of Fos-positive PAG neurons projected to the ventral medulla. This indicates that MPO stimulation engages PAG-medullary output neurons. Taken together, these results suggest that the MPO + PAG + RVM projection constitutes a functional pathway. This circuit may coordinately regulate neuroendocrine, motor, and autonomic adjustments necessary for the elaboration of sexual behaviors.Key words: reproduction; antinociception; cardiovascular regulation; brainstem; sexual behavior; immunohistochemistryThe medial preoptic area (h/[PO) is a sexually dimorphic structure Simerly et al., 1984;Bloch and Gorski, 1988) that plays a pivotal role in sexual behavior and neuroendocrine function (Lisk, 1966;Powers and Valenstein, 1972;Pfaff and Sakuma, 1979;Hansen et al., 1982;Arendash and Gorski, 1983;Kalra and Kalra, 1983;Docke et al., 1984;Sachs and Meisel, 1988;Simerly et al., 1990;DonCarlos et al., 1991;Takeo et al., 1993;Hoshina et al., 1994). We recently reported that MPO robustly innervates the midbrain periaqueductal gray (PAG) (Rizvi et al., 1992) and terminates in discrete, longitudinally organized columns running through the rostrocaudal axis of PAG.PAG plays a key role in antinociception (Reynolds, 1969;Liebeskind et al., 1973;Oliveras et al., 1974;Behbehani and Fields, 1979; Lovick, 3985;Morgan and Liebeskind, 1987;Reichling et al., 1988;Lovick, 1990), cardiovascular control (Lovick, 1985;Carrive et al., 1987;Carrive et al., 1988;Carrive et al., 1989a;Lovick, 1990;Verberne and Guyenet, 1992;Murphy et al., 1994a;Murphy et al., 1995), and many of the same neuroendocrine and reproductive functions as MPO (Pfaff and SchwartzGiblin, 1988;Ogawa et al., 1991;Shipley et al., 1995). PAG neurons involved in these functions also are ...

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Neural mechanisms for the functional coupling of autonomic, endocrine and somatomotor responses in adaptive behavior

Cited by 237 publications

References 148 publications

Distribution of type 1 cannabinoid receptor‐expressing neurons in the septal‐hypothalamic region of the mouse: Colocalization with GABAergic and glutamatergic markers

Distribution of type 1 cannabinoid receptor‐expressing neurons in the septal‐hypothalamic region of the mouse: Colocalization with GABAergic and glutamatergic markers

Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

Medial preoptic area afferents to periaqueductal gray medullo-output neurons: a combined Fos and tract tracing study

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