Neural mechanism of spatio-chromatic opponency in the Drosophila amacrine neurons

Li, Yan; Chen, Pei‐Ju; Lin, Te‐Yu; Ting, Chun-Yuan; Muthuirulan, Pushpanathan; Pursley, Randall; Ilić, Marko; Pirih, Primož; Drews, Michael; Menon, Kaushiki P.; Zinn, Kai; Pohida, Thomas J.; Borst, Alexander; Lee, Chi-Hon

doi:10.1016/j.cub.2021.04.068

Cited by 20 publications

(33 citation statements)

References 64 publications

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“…We have additionally identified as pale-specific the aMe12 and ML-VPN1 cell types, and the yellow bias of Tm5c and the pale bias of Mi9 ( Figure 11Bii ). Our detailed analysis of Dm8 inputs confirmed that these neurons receive most of their photoreceptor input in a central home column, consistent with pale and yellow subtypes of Dm8 cells having distinct chromatic properties ( Courgeon and Desplan, 2019 ; Menon et al, 2019 ; Li et al, 2021 ; Pagni et al, 2021 ). The selective photoreceptor input to these cell types, combined with input to columnar cells from a single photoreceptor subtype, indicates that wavelength-specific information is maintained in the medulla and lobula ( Figure 11Bi ).…”

Section: Discussionsupporting

confidence: 77%

“…L3 could contribute to color processing through innervation of Dm9, Tm20, and Tm5c ( Takemura et al, 2015 ), in addition to the ON and OFF pathways computing motion ( Silies et al, 2013 ). Our reconstructions therefore provide further support for the early convergence of motion and color channels, which have until recently been believed to operate separately ( Heisenberg and Buchner, 1977 ; Yamaguchi et al, 2008 ; Wardill et al, 2012 ; Pagni et al, 2021 ; Li et al, 2021 ).…”

Section: Resultssupporting

confidence: 67%

“…Other cell types also received inner photoreceptor input outside the medulla, notably the lamina monopolar cells L1 and L3. These lamina connections indicate that chromatic comparisons arising from R7 and R8 may feed into the motion vision pathway, and identifies a new site for interplay between the ‘color’ and ‘motion’ pathways ( Wardill et al, 2012 ; Schnaitmann et al, 2013 ; Pagni et al, 2021 ; Li et al, 2021 ). Together, these observations suggest that synapses in an unexpected location, outside the main synaptic layers of the medulla, could play a significant role in early visual processing.…”

Section: Discussionmentioning

confidence: 88%

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Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila

Kind

Longden

Nern

et al. 2021

eLife

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Color and polarization provide complementary information about the world and are detected by specialized photoreceptors. However, the downstream neural circuits that process these distinct modalities are incompletely understood in any animal. Using electron microscopy, we have systematically reconstructed the synaptic targets of the photoreceptors specialized to detect color and skylight polarization in Drosophila, and we have used light microscopy to confirm many of our findings. We identified known and novel downstream targets that are selective for different wavelengths or polarized light, and followed their projections to other areas in the optic lobes and the central brain. Our results revealed many synapses along the photoreceptor axons between brain regions, new pathways in the optic lobes, and spatially segregated projections to central brain regions. Strikingly, photoreceptors in the polarization-sensitive dorsal rim area target fewer cell types, and lack strong connections to the lobula, a neuropil involved in color processing. Our reconstruction identifies shared wiring and modality-specific specializations for color and polarization vision, and provides a comprehensive view of the first steps of the pathways processing color and polarized light inputs.

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Section: Discussionsupporting

confidence: 77%

Section: Resultssupporting

confidence: 67%

Section: Discussionmentioning

confidence: 88%

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Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila

Kind

Longden

Nern

et al. 2021

eLife

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“…This would be detrimental for the signal-to-noise ratio in the achromatic visual pathway relayed via the lamina monopolar cells (LMCs). The opponent signalling from SW to LW is likely implemented at a later stage in the visual pathway, probably via interneurons in the medulla [8,9]. In the complex nymphalid retina with red ommatidia, the tiny, light-starved, high-gain R9 cells can utilise a novel, private opponent channel in the form of green-sensitive LVF R1&2, thereby avoiding to send an opponent signal into the R3-8 achromatic pathway.…”

Section: Discussionmentioning

confidence: 99%

Opponent processing in the retinal mosaic of nymphalid butterflies

Pirih

Ilić

Meglič

et al. 2022

Preprint

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The eyes of nymphalid butterflies, investigated with incident illumination, show colourful facet reflection patterns, the eye shine, which is uniform or heterogeneous, dependent on the species. Facet colours suggest that the ommatidia contain different sets of photoreceptors and screening pigments, but how the colours and the cell characteristics are associated has not been clearly established. Here we analyse the retinae of two nymphalids, Apatura ilia, which has a uniform eyeshine, and Charaxes jasius, a species with a heterogeneous eye shine, using single-cell recordings, spectroscopy and optical pupillometry. Apatura has UV, blue and green-sensitive photoreceptors, allocated into three ommatidial types. The UV and blue-sensitive cells are long visual fibres (LVFs), receiving opponent input from the green-sensitive short visual fibres (SVFs). Charaxes has an expanded set of photoreceptors, allocated into three additional, red-reflecting ommatidial types. All red ommatidia contain green-sensitive LVFs, receiving opponent input from red receptors. In both species, the SVFs do not receive any opponent input. The simple retina of Apatura with three ommatidial types and two colour-opponent channels can support trichromatic vision. Charaxes has six ommatidial types and three colour-opponent channels. Its expanded receptor set can support tetrachromatic vision.

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“…The UV information from R7 is also combined with signals from the R1–R6 cells in a class of medullar neurons called distal medulla 8 (Dm8) ( Karuppudurai et al, 2014 ; Li et al, 2021 ; Pagni et al, 2021 ), which is required for the UV preference behavior ( Gao et al, 2008 ; Karuppudurai et al, 2014 ). Dm8 receives hyperpolarizing input from R7 via Ort receptors and depolarizing input from Mi1/Tm3 cells via cholinergic receptors, whose light responses are derived from R1–R6 ( Li et al, 2021 ; Pagni et al, 2021 ). Consequently, Dm8 neurons hyperpolarize to UV light and depolarize to blue/green light.…”

Section: Brightness Color and Phototaxismentioning

confidence: 99%

From Photons to Behaviors: Neural Implementations of Visual Behaviors in Drosophila

Ryu

Kim

2022

Front. Neurosci.

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Neural implementations of visual behaviors in Drosophila have been dissected intensively in the past couple of decades. The availability of premiere genetic toolkits, behavioral assays in tethered or freely moving conditions, and advances in connectomics have permitted the understanding of the physiological and anatomical details of the nervous system underlying complex visual behaviors. In this review, we describe recent advances on how various features of a visual scene are detected by the Drosophila visual system and how the neural circuits process these signals and elicit an appropriate behavioral response. Special emphasis was laid on the neural circuits that detect visual features such as brightness, color, local motion, optic flow, and translating or approaching visual objects, which would be important for behaviors such as phototaxis, optomotor response, attraction (or aversion) to moving objects, navigation, and visual learning. This review offers an integrative framework for how the fly brain detects visual features and orchestrates an appropriate behavioral response.

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Neural mechanism of spatio-chromatic opponency in the Drosophila amacrine neurons

Cited by 20 publications

References 64 publications

Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila

Synaptic targets of photoreceptors specialized to detect color and skylight polarization in Drosophila

Opponent processing in the retinal mosaic of nymphalid butterflies

From Photons to Behaviors: Neural Implementations of Visual Behaviors in Drosophila

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