Neural mechanism of residual inhibition of tinnitus in cochlear implant users

Osaki, Yasuhiro; Nishimura, Hiroshi; Takasawa, Masashi; Imaizumi, Masao; Kawashima, Takayuki; Iwaki, Toru; Oku, Naohiko; Hashikawa, Kazuo; Doi, Kunio; Nishimura, Tsunehiko; Hatazawa, Jun; Kubo, Takeshi

doi:10.1097/01.wnr.0000183899.85277.08

Cited by 65 publications

(41 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With respect to sample size, many neuroimaging studies draw conclusions about the underlying TI pathophysiology using group statistics with fewer than ten patients (e.g. Giraud et al, 1999;Kadner et al, 2002;Lockwood et al, 1998;Osaki et al, 2005). While such analyses might be adequate for characterising the common pathophysiology in that particular sample of patients, little can be inferred about the mechanisms underlying TI in the wider population.…”

Section: Discussionmentioning

confidence: 99%

“…The neural effects of TI suppression achieved after residual inhibition has also been examined with PET (Osaki et al, 2005). Residual inhibition refers either to a partial or a complete temporary suppression of TI that lasts approximately 60 seconds after the cessation of a suprathreshold masking sound presented for a period of 30 to 60 seconds (Henry and Meikle, 2000).…”

Section: Human Neuroimaging Studiesmentioning

confidence: 99%

See 1 more Smart Citation

The mechanisms of tinnitus: Perspectives from human functional neuroimaging

2009

View full text Add to dashboard Cite

In this review, we highlight the contribution of advances in human neuroimaging to the current understanding of central mechanisms underpinning tinnitus and explain how interpretations of neuroimaging data have been guided by animal models. The primary motivation for studying the neural subtrates of tinnitus in humans has been to demonstrate objectively its representation in the central auditory system and to develop a better understanding of its diverse pathophysiology and of the functional interplay between sensory, cognitive and affective systems. The ultimate goal of neuroimaging is to identify subtypes of tinnitus in order to better inform treatment strategies. The three neural mechanisms considered in this review may provide a basis for TI classification. While human neuroimaging evidence strongly implicates the central auditory system and emotional centres in TI, evidence for the precise contribution from the three mechanisms is unclear because the data are somewhat inconsistent. We consider a number of methodological issues limiting the field of human neuroimaging and recommend approaches to overcome potential inconsistency in results arising from poorly matched participants, lack of appropriate controls and low statistical power. AbstractIn this review, we highlight the contribution of advances in human neuroimaging to the current understanding of central mechanisms underpinning tinnitus and explain how interpretations of neuroimaging data have been guided by animal models. The primary motivation for studying the neural subtrates of tinnitus in humans has been to demonstrate objectively its representation in the central auditory system and to develop a better understanding of its diverse pathophysiology and of the functional interplay between sensory, cognitive and affective systems. The ultimate goal of neuroimaging is to identify subtypes of tinnitus in order to better inform treatment strategies. The three neural mechanisms considered in this review may provide a basis for TI classification. While human neuroimaging evidence strongly implicates the central auditory system and emotional centres in TI, evidence for the precise contribution from the three mechanisms is unclear because the data are somewhat inconsistent. We consider a number of methodological issues limiting the field of human neuroimaging and recommend approaches to overcome potential inconsistency in results arising from poorly matched participants, lack of appropriate controls and low statistical power.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Human Neuroimaging Studiesmentioning

confidence: 99%

The mechanisms of tinnitus: Perspectives from human functional neuroimaging

2009

View full text Add to dashboard Cite

show abstract

“…Positron emission tomography (PET) demonstrated that in patients with marked residual inhibitory effect of CI on tinnitus, the right anterior middle and superior temporal gyri were activated during residual inhibition after implant use, whereas the right cerebellum was activated during tinnitus perception [Osaki et al, 2005]. A further PET study revealed that the use of cochlear implants not only reduced the tinnitus-related activity in primary auditory and associate cortices but also in areas of the CNS associated with emotion (limbic system) and attention (dorsolateral prefrontal cortices) [Mirz et al, 2002].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Cochlear Implantation on Tinnitus, Stress and Quality of Life in Postlingually Deafened Patients

et al. 2011

View full text Add to dashboard Cite

Tinnitus is a common complaint in the candidates for cochlear implantation (CI). Tinnitus-related distress has often been measured in these patients using categorical ratings, which lack information about tinnitus severity, stress and health-related quality of life or their correlation. Here, using 4 validated questionnaires, we evaluated psychometric parameters and the quality of life of 32 postlingually deafened patients before and after CI. The data regarding pre-CI were collected retrospectively. Of all patients included in this study, 28 (87.5%) suffered from tinnitus before implantation. Following a mean of 24 months after surgery, these patients reported a significant decrease (39.2%) of tinnitus impairment, as measured by the Tinnitus Questionnaire. In none of the 28 patients has tinnitus worsened. Moreover, the 4 tinnitus-free patients remained so after the CI surgery. In addition, the implant supply resulted in 36.7% reduction in perceived stress and in 15.4% reduction in evasive coping. In addition, the focus on positive coping has improved by 12.3%, whereas the health-related quality of life improved by 53.4% in all patients. Tinnitus impairment and stress were reduced more strongly in patients who had initially higher scores. Interestingly, a significant correlation between the psychometric scores was found mainly after CI. Our results indicate that patients with higher tinnitus-related distress have a lower quality of life, lesser coping abilities and perceive more stress, but before implantation it is masked by deafness. We conclude that tinnitus-related screening of patients before and after CI is an important step in the identification of individuals who would benefit from specific fitting and/or tinnitus therapy after implantation.

show abstract

“…Is this suppression due to the reversal of the assumed maladaptive plasticity or is it simply the shift in attention from the tinnitus to environmental sound and therefore less awareness that reduces tinnitus perception [Searchfield et al, 2012]? The former mechanism is supported by the presence of residual inhibition in many patients, a persistency in the tinnitus reduction after the stimulation is deactivated [Osaki et al, 2005;Arts et al, 2015]. Therefore, it should be possible to treat tinnitus by intracochlear electrical stimulation that does not directly encode acoustic sound.…”

Section: Introductionmentioning

confidence: 96%

Tinnitus Suppression by Intracochlear Electrical Stimulation in Single-Sided Deafness: A Prospective Clinical Trial - Part I

et al. 2015

View full text Add to dashboard Cite

Cochlear implantation is a viable treatment option for tinnitus, but the underlying mechanism is yet unclear. Is the tinnitus suppression due to the reversal of the assumed maladaptive neuroplasticity or is it the shift in attention from the tinnitus to environmental sounds and therefore a reduced awareness that reduces tinnitus perception? In this prospective trial, 10 patients with single-sided deafness were fitted with a cochlear implant to investigate the effect of looped intracochlear electrical stimulation (i.e. stimulation that does not encode environmental sounds) on tinnitus, in an effort to find optimal stimulation parameters. Variables under investigation were: amplitude (perceived stimulus loudness), anatomical location inside the cochlea (electrode/electrodes), amplitude modulation, polarity (cathodic/anodic first biphasic stimulation) and stimulation rate. The results suggest that tinnitus can be reduced with looped electrical stimulation, in some cases even with inaudible stimuli. The optimal stimuli for tinnitus suppression appear to be subject specific. However, medium-to-loud stimuli suppress tinnitus significantly better than soft stimuli, which partly can be explained by the masking effect. Although the long-term effects on tinnitus would still have to be investigated and will be described in part II, intracochlear electrical stimulation seems a potential treatment option for tinnitus in this population.

show abstract

Neural mechanism of residual inhibition of tinnitus in cochlear implant users

Cited by 65 publications

References 21 publications

The mechanisms of tinnitus: Perspectives from human functional neuroimaging

The mechanisms of tinnitus: Perspectives from human functional neuroimaging

The Impact of Cochlear Implantation on Tinnitus, Stress and Quality of Life in Postlingually Deafened Patients

Tinnitus Suppression by Intracochlear Electrical Stimulation in Single-Sided Deafness: A Prospective Clinical Trial - Part I

Contact Info

Product

Resources

About