Neural mass modelling reveals that hyperexcitability underpins slow-wave sleep changes in children with epilepsy
Dominic M Dunstan,
Samantha YS Chan,
Marc Goodfellow
Abstract:ObjectiveThe relationship between sleep and epilepsy is important but imperfectly understood. We sought to understand why children with epilepsy have altered sleep homeostasis.MethodsWe used neural mass models to replicate sleep EEG recorded from 15 children with focal lesional epilepsies and 16 healthy age-matched controls.ResultsThe models revealed that sleep EEG differences are driven by enhanced firing rates in the neuronal populations of patients, which arise predominantly due to enhanced excitatory synap… Show more
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