Neural ensembles that encode affective mechanical and heat pain in mouse spinal cord
Ming-Dong Zhang,
Jussi Kupari,
Jie Su
et al.
Abstract:Acute pain is an unpleasant experience caused by noxious stimuli. How the spinal neural circuits attribute differences in quality of noxious information remains unknown. By means of genetic capturing, activity manipulation and single cell RNA sequencing, we identified distinct neural ensembles in mouse spinal cord encoding mechanical and heat pain. Re-activation or silencing of these ensembles potentiated or stopped, respectively, affective but not reflex behaviour without altering pain behaviour to cross stim… Show more
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