Neural elements behind the hepatoprotection of remote perconditioning

Czigány, Zoltán; Turóczi, Zsolt; Kleiner, Dénes; Lotz, Gábor; Homeyer, André; Harsányi, László; Szíjártó, Attila

doi:10.1016/j.jss.2014.08.046

Cited by 19 publications

(25 citation statements)

References 37 publications

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“…Perconditioning induction diminished the extent of these injured tubules, although such protective effects were not observed in the RPEC-NR group where cross-section of the nerve prior to the ischemic conditioning treatment provoked renal morphological changes. The notable infarct size reducing effects of remote perconditioning were also reported by Lu et al (18) and Czigány et al (11) in different experimental methods of myocardial infarction and liver I/R.…”

Section: Discussionsupporting

confidence: 74%

“…Thus, activating a sub-cellular cascade of kinases as a protective mechanism (9). Previous studies have indicated that manipulation of hindlimb innervations prior to induction of ischemic perconditioning treatment exerts an effect on perconditioning-induced renoprotection (10,11). Our previous study was the first to report the protective effects of RPEC on the I/R injury of the kidney (12).…”

Section: Introductionmentioning

confidence: 98%

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Involvement of neuronal pathways in the protective effects of hindlimb perconditioning during renal ischemia

Sedaghat

Kadkhodaee

Seifi

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Remote ischemic perconditioning (RPEC) is a therapeutic intervention that has been demonstrated to reduce renal ischemia/reperfusion (I/R) injury. However, the underlying renal protective mechanism remains unclear. The present study hypothesized that RPEC may utilize neural pathways to transfer the protective signal from the perconditioned hindlimb to the kidney. Following a right nephrectomy, rats were randomly allocated into five groups (n=6). The sham group underwent the surgical protocol only. In all other groups, the left renal pedicle was clamped for 45 min and reperfused for 24 h. The I/R control group then underwent 45 min ischemia and 24 h reperfusion (I/R) with no more intervention but the I/R-NR control group underwent the ischemia and reperfusion followed by left femoral nerve (FN) and sciatic nerve (SN) resection. The RPEC group underwent ischemia and reperfusion followed by four cycles of 5 min occlusions of the left femoral artery and 5 min reperfusion. Finally, the RPEC-NR group underwent ischemia and reperfusion followed by left FN and SN resection. Following 24 h, renal functional indices, plasma blood urea nitrogen (BUN) and creatinine (Cr) levels, urinary N-acetyl-β-glucosaminidase (NAG) release and histopathological changes were assessed. Compared with the sham group, ischemia and reperfusion in the sham and I/R control groups resulted in renal dysfunction, indicated by significantly increased levels of BUN and Cr. This was accompanied by increased urinary NAG activity and morphological damage observed in control groups. In the RPEC group, renal histology and function were significantly improved compared with the control groups. However, FN and SN resection eliminated the protection of the kidney, which was induced by RPEC. In conclusion, remote hindlimb ischemic perconditioning reduced renal I/R injury in the rat kidney in a manner that potentially involves a neural pathway.

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Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 98%

Involvement of neuronal pathways in the protective effects of hindlimb perconditioning during renal ischemia

Sedaghat

Kadkhodaee

Seifi

et al. 2017

Experimental and Therapeutic Medicine

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“…Ezt követő, szelektív denervációs kísérletünkben a perkondicionáló kezelés protektív hatásának neuralis komponensét vizsgáltuk, ahol az idegblokád alkalmazása a hepa toprotekció globális, szignifi káns csökkenését eredményezte. Bár a redox-homeosztázis tekintetében utób-bi igaz a szabadgyök-terhelés szempontjából, a denervá-ció nem szüntette meg az antioxidánsszintek javulását [27]. A -kardiológiai alkalmazása kapcsán inodilatátor hatású szerként ismert -levosimendan a klasszikus kémi-ai kondicionálószerek közé tartozik.…”

Section: Kondicionáló Eljárások éS Máj Ischaemiareperfúzió -áLlatkíséunclassified

Szabad gyökök és a máj ischaemiás-reperfúziós károsodása

Szíjártó

2015

Orvosi Hetilap

Self Cite

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Az ischaemiás-reperfúziós károsodás kiemelkedő jelentősége számos szerv és klinikai szituáció esetén jól bizonyított. A posztoperatív komplikációk prevalenciáját, a célszerv sérülését és a szisztémás szövődmények előfordulását jelentő-sen meghatározó károsodás mediálásában központi szerep jut a szabad gyököknek. A szabadgyök-stresszre kimondottan érzékeny máj anatómiailag és patofi ziológiailag speciális ischaemiás-reperfúziós károsodása májsebészeti szempontból kulcsfontosságú. A reperfúziós károsodás mérséklésére számos kondicionáló eljárás (adaptív technikák, kémiai vegyületek) ismert. Jelen összefoglaló célja az ischaemiás-reperfúziós károsodás mérséklésére irányuló technikák áttekintése a szerző kutatócsoportjának eddigi munkássága (ischaemiás prekondicionálás, -perkondicionálás, glutaminszupplementáció, adenozin-, inozin-, levosimendan-, poli-ADP-ribóz polimerázgátlás szerepe) alapján, külö-nös tekintettel a máj ischaemiás-reperfúziós károsodására, valamint a szabad gyökök abban betöltött patofi ziológiai szerepére. Orv. Hetil., 2015, 156(47), 1904-1907. Kulcsszavak: ischaemiás-reperfúziós károsodás, máj, szabad gyök, ischaemiás prekondicionálás Free radicals and hepatic ischemia-reperfusionThe critical importance of the ischemic-reperfusive injury is well documented with regards to numerous organs and clinical conditions. Oxygen free radicals play a central role in the mediation of the injury, which dominantly infl uences the prevalence of postoperative complications, (long term) organ damage, and the potential manifestation of systemic reactions. The both anatomically and pathophysiologically unique ischemic-reperfusive injury of the liver, which is expressively vulnerable to free radicals, is of utmost importance in liver surgery. Several techniques (adaptive maneuvers, chemical agents) are known to ameliorate the reperfusive injury. Based on the prior research of the workgroup of the author, the aim of the current article is to overview the set of measures capable of attenuating ischemic-reperfusive injury (ischemic preconditioning, -perconditioning, administration of adenosine, -inosine, -levosimendan, and -poly-ADP-ribose-polymerase inhibitor), with special attention to the ischemic-reperfusive injury of the liver, as well as the special pathophysiological role of free radicals in mediating hepatic damage. Keywords: ischemia-reperfusion injury, liver, free radicals, ischemic preconditioningSzijártó, A. [Free radicals and hepatic ischemia-reperfusion]. Orv. Hetil., 2015, 156(47), 1904-1907. (Beérkezett: 2015 elfogadva: 2015. szeptember 23.) Rövidítések ADP = adenozin-difoszfát; ALP = alkalikus foszfatáz; ALT = alanin-aminotranszferáz; AMP = adenozin-monofoszfát; ATP = adenozin-triszfoszfát; CARS = compensatory anti-infl ammatory response syndrome; CX = (circumfl ex artery) bal szívkoszorúér körbefutó ága; DAMP = danger-associated molecular pattern; DNS = dezoxiribonukleinsav; GSH = glutation redukált forma; I-R = ischaemia-reperfúzió; ic. = intracelluláris; IFN-γ = interferon-γ; IL-1β = interleuk...

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“…Current clinical strategies are unable to fulfil the demands presented by the transplantation of so‐called marginal grafts, and the need for optimized preservation techniques that address the underlying impairment of ECD allografts is paramount. In recent years, the main research focus of several groups, including ours, has therefore been the development of improved organ preservation and organ conditioning approaches . Machine perfusion (MP) has been recognized as a promising preservation strategy in the context of OLT using ECD allografts.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, the main research focus of several groups, including ours, has therefore been the development of improved organ preservation and organ conditioning approaches. [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] Machine perfusion (MP) has been recognized as a promising preservation strategy in the context of OLT using ECD allografts. While SCS only prolongs storage time and limits the damage sustained during the period of cold ischaemia, MP even appears to be capable of reversing some of these effects.…”

Section: Introductionmentioning

confidence: 99%

Machine perfusion for liver transplantation in the era of marginal organs—New kids on the block

Czigány

Lurje

Tolba

et al. 2018

Liver International

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In the face of a critical organ shortage in the Western world, various strategies are employed to expand the donor pool for orthotopic liver transplantation (OLT). Among them is the transplantation of organs from extended criteria donors, a valuable source of liver allografts, however, characterized by potential risks for post-OLT complications and inferior outcomes. In recent years, machine perfusion (MP) of the explanted donor liver as well as regional perfusion techniques has witnessed significant advancements. Here, we aim to discuss different modes of dynamic organ preservation in OLT. These include hypothermic and normothermic MP, hypothermic oxygenated machine perfusion (HOPE), controlled oxygenated rewarming as well as regional perfusion protocols. Over recent years, multiple feasibility trials have demonstrated the clinical prospects of MP. In the context of OLT using organs from extended criteria donors, MP has numerous advantages compared to conventional cold storage, some of which include the preservation and reconditioning of borderline transplantable organs and the viability assessment of high-risk donor allografts. This review aims to address the topic of liver allograft MP, highlighting particularly the current trends in clinical applications and future perspectives. Furthermore, different approaches of liver storage and reconditioning are reviewed in the context of ongoing research.

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Neural elements behind the hepatoprotection of remote perconditioning

Cited by 19 publications

References 37 publications

Involvement of neuronal pathways in the protective effects of hindlimb perconditioning during renal ischemia

Involvement of neuronal pathways in the protective effects of hindlimb perconditioning during renal ischemia

Szabad gyökök és a máj ischaemiás-reperfúziós károsodása

Machine perfusion for liver transplantation in the era of marginal organs—New kids on the block

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