Neural dysfunction during hypoglycaemia.

Abstract

SUMMARYThere is controversy over the definition of hypoglycaemia in neonates and children and over its significance when 'asymptomatic'. We measured sensory evoked potentials in relation to blood glucose concentration in 17 children: 13 were fasted or given insulin to investigate endocrine or metabolic abnormalities and four had spontaneous episodes of hypoglycaemia. Abnormal evoked potentials were recorded in 10 of

Insulin kinetics and the Neonatal Intensive Care Insulin–Nutrition–Glucose (NICING) model

“…Use of insulin has been shown to increase glucose tolerance [22][23][24][25][26][27], resulting in increased weight gain [23,25,27], but also commonly results in increased incidence of hypoglycaemia (low blood glucose concentration) [28][29][30], which is also dangerous. In adult intensive care even a single hypoglycaemic episode has been associated with increased risk of mortality [31][32][33], while in neonatal intensive care hypoglycaemia as been associated with adverse neurological outcomes [34,35]. Model-based methods for glycaemic control have been little investigated, due in part to the extremely fragile nature of this cohort and the subsequent limitations on invasive procedures and blood sample collection [36] that thus also limit the ability to identify parameters to validate more physiologically relevant and complex models.…”

Relationship between Umbilical Cord C-peptide and Risk of Hypoglycemia in Infants of Diabetic Mothers

“…Neonatal hypoglycemia is associated with poor psychoneurological outcome. Evidence suggests that blood glucose should be maintained above 2.6 mmol/l to ensure normal neural function in infants irrespective of the presence or absence of abnormal clinical signs 18 .…”

Evaluation of central nervous system in patients with glycogen storage disease type 1a

“…The electrodes were placed on to the scalp according to [10][11][12][13][14][15][16][17][18][19][20] System. Both eyes were tested separately and the opposite eye was occluded during the test.…”