Neural development of selective attention and response inhibition

Booth, James R.; Burman, Douglas D.; Meyer, Jacob; Zhang, Lei; Trommer, Barbara L.; Davenport, Nicholas D.; Li, Wei; Parrish, Todd B.; Gitelman, Darren R.; Mesulam, Marek-Marsel

doi:10.1016/s1053-8119(03)00404-x

Cited by 313 publications

(259 citation statements)

References 82 publications

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“…For the frontal cortex it has been suggested that task unrelated activity decreases during maturation, whereas task related activity increases (Booth et al, 2003;Bunge et al, 2002;Casey et al, 2005;Schlaggar et al, 2002). As far as we know, this is the first study to show that a similar developmental mechanism occurs within the parietal lobule and in area V3a within the dorsal part of the occipital cortex.…”

Section: Discussionsupporting

confidence: 55%

Dorsal stream development in motion and structure-from-motion perception

et al. 2008

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(2008). Dorsal stream development in motion and structure-from-motion perception. NeuroImage, 39(4): [1815][1816][1817][1818][1819][1820][1821][1822][1823] Little is known about the neural development underlying high order visual perception. For example, in detection of structures by coherently moving dots, motion information must interact with shape-based information to enable object recognition. Tasks involving these different motion-based discriminations are known to activate distinct specialized brain areas in adults. Here, we investigate neural development of normally developing children using functional magnetic resonance imaging (fMRI) during perception of randomly moving point-light dots (RM), coherently moving dots that formed a 3D rotating object (SFM) and static dots. Perception of RM enhanced neural activity as compared with static dots in motion processing-related visual areas, including visual area 3a (V3a), and middle temporal area (hMT+) in 10 adults (age 20-30 years). Children (age 5-6 years) showed less pronounced activity in area V3a than adults. Perception of SFM induced enhanced neural activity as compared to RM in adults in the left parietal shape area (PSA), whereas children increased neural activity within dorsal (V3a) and ventral brain areas (lingual gyrus) of the occipital cortex. These findings provide evidence of neural development within the dorsal pathway. First, maturation was associated with enhanced activity in specialized areas within the dorsal pathway during RM perception (V3a) and SFM perception (PSA). Secondly, high order visual perception-related neural development was associated with a shift in neural activity from low level shape and motion specialized areas in children, including partially immature area V3a, to high order areas in the parietal lobule (PSA) in adults.

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Section: Discussionsupporting

confidence: 55%

Dorsal stream development in motion and structure-from-motion perception

et al. 2008

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“…The overactivated area is known to participate in various stages of producing a strong emotional arousal. 34 The striatum is associated with the emotional integration and with transferring emotional signals to the peripheral nervous system.When attention shifting from emotion processing, in comparison with the HC-FHN group, the MDD-FHN group experience reduced activation in the right SuMG, an area participating in attentional shifts 72 and inhibition 73 in healthy controls. Reductions of activation in this area have been previously reported in elderly patients with MDD when they were asked to focus their observation on a particular target.…”

Section: Figmentioning

confidence: 82%

Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression

Lisiecka

Carballedo

Fagan

et al. 2013

J Psychiatry Neurosci

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IntroductionIndividuals with a first-degree relative who has major depressive disorder (MDD) are at a 2-to 3-fold greater risk for depression than those without a family history of MDD. 1 Rela tives of depressed patients, compared with individuals without family history of psychiatric disorders, are characterized by elevated neuroticism, depressive cognitions and rigidity 2 and by stability of these traits over time.3 Patients with MDD who had relatives with an affective disorder display greater neuroticism 4 and have an earlier age of onset of MDD. 5 Evidently, family history of MDD alters susceptibility to depression and to an acute MDD episode. The factor is clinically important since it involves mechanisms of elevated risk for MDD (relatives of patients with MDD compared with healthy controls), suggests relative resilience to the disease (relatives of patients with MDD compared with the patients themselves) and points to different endophenotypes of healthy controls and patients with MDD. A good understanding of these mechanisms should not be underestimated if diagnosis, therapy and prevention of the disorder are to be enhanced. Background: Family history of major depressive disorder (MDD) increases individuals' vulnerability to depression and alters the way depression manifests itself. Emotion processing and attention shifting are functions altered by MDD and family history of the disease; therefore, it is important to recognize the neural correlates of these functions in association with both factors. Methods: Our study determines neural correlates of emotion processing and attention shifting for healthy individuals and patients with MDD with and without family history of depression. We compared the performance and neural activity in a functional magnetic resonance imaging experiment examining emotion processing and attention shifting in all participants. Results: Our sample included 4 study groups: healthy controls without family history of depression (n = 25), patients with MDD without family history of the disease (n = 20), unaffected healthy first-degree relatives of patients with MDD (n = 21) and patients with MDD with family history of MDD (n = 30). Compared with healthy controls, unaffected first-degree relatives overactivate the somatosensory cortex and the attention controlling areas during both emotion processing and attention shifting. Patients with family history of MDD have stronger neural activation in subcortical areas during shifting attention from negative stimuli. Patients without family history of MDD have less activation in the paralimbic regions and more activation in core limbic areas, especially during emotion processing. Limitations: The conclusions about the intergroup differences in activation can be drawn only about neural areas engaged in the task. Conclusion: Unaffected first-degree relatives of patients with MDD overreact to external emotional cues and compensate for the vulnerability with increased involvement of executive control. Patients with a family history of MDD have le...

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“…This chemogenetic dissection approach can serve as a powerful tool to deduce which circuits inhibited by global dACC inactivation primarily contribute to attention deficits. Finally, noninvasive nature of chemogenetic approach is particularly well-suited to examine how established dynamic changes in network activity across adolescence contribute to brain development (Booth et al, 2003;Fair et al, 2007).…”

Section: Inactivation Of Dacc Neurons Disrupts Attention In Mousementioning

confidence: 99%

Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse

Koike

Demars

Short

et al. 2015

Neuropsychopharmacol

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Attention is disrupted commonly in psychiatric disorders, yet mechanistic insight remains limited. Deficits in this function are associated with dorsal anterior cingulate cortex (dACC) excitotoxic lesions and pharmacological disinhibition; however, a causal relationship has not been established at the cellular level. Moreover, this association has not yet been examined in a genetically tractable species such as mice. Here, we reveal that dACC neurons causally contribute to attention processing by combining a chemogenetic approach that reversibly suppresses neural activity with a translational, touchscreen-based attention task in mice. We virally expressed inhibitory hM4Di DREADD (designer receptor exclusively activated by a designer drug) in dACC neurons, and examined the effects of this inhibitory action with the attention-based five-choice serial reaction time task. DREADD inactivation of the dACC neurons during the task significantly increased omission and correct response latencies, indicating that the neuronal activities of dACC contribute to attention and processing speed. Selective inactivation of excitatory neurons in the dACC not only increased omission, but also decreased accuracy. The effect of inactivating dACC neurons was selective to attention as response control, motivation, and locomotion remain normal. This finding suggests that dACC excitatory neurons play a principal role in modulating attention to task-relevant stimuli. This study establishes a foundation to chemogenetically dissect specific cell-type and circuit mechanisms underlying attentional behaviors in a genetically tractable species.

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Neural development of selective attention and response inhibition

Cited by 313 publications

References 82 publications

Dorsal stream development in motion and structure-from-motion perception

Dorsal stream development in motion and structure-from-motion perception

Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression

Chemogenetic Inactivation of Dorsal Anterior Cingulate Cortex Neurons Disrupts Attentional Behavior in Mouse

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