“…During development, Notch receptors can regulate gross neuronal morphology and fine synaptic architecture through both canonical and non-canonical signaling in diverse species. This includes regulation of neuronal migration [ 144 , 145 , 146 , 147 ], neurite outgrowth and morphogenesis [ 148 , 149 , 150 , 151 , 152 , 153 , 154 , 155 , 156 , 157 , 158 ], axon guidance and targeting [ 159 , 160 , 161 , 162 , 163 , 164 ], dendrite morphogenesis [ 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 ], synaptogenesis [ 173 , 174 ], and synaptic growth [ 121 , 175 ]. Hence, one may consider that Notch signaling may regulate neuronal and synaptic physiology by fine-tuning cellular mechanisms that lead to structural alterations in the post-developmental brain.…”