Neural crest cells development and neuroblastoma progression: Role of Wnt signaling

Ahmad, Mir Hilal; Ghosh, Balaram; Rizvi, Moshahid Alam; Ali, Mansoor; Kaur, Loveleena; Mondal, Amal Chandra

doi:10.1002/jcp.30931

Cited by 4 publications

(5 citation statements)

References 206 publications

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“…According to our KEGG results, the DEGs identified were mainly enriched in the Wnt signaling pathway, which has been shown to play vital roles in epidermal development, stem cell self-renewal, and wound healing [ 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. The horns of ruminants have a common cellular origin from neural crest cells [ 3 ] and the Wnt signaling pathway is essential for regulating the fate, migration, and proliferation of cranial neural crest cells [ 62 , 63 , 64 , 65 ]. In addition, antler regeneration may be influenced by the Wnt signaling pathway [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Identification of Critical Genes for Ovine Horn Development Based on Transcriptome during the Embryonic Period

Luan

Wang

et al. 2023

Biology

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Horns, also known as headgear, are a unique structure of ruminants. As ruminants are globally distributed, the study of horn formation is critical not only for increasing our understanding of natural and sexual selection but also for the breeding of polled sheep breeds to facilitate modern sheep farming. Despite this, a significant number of the underlying genetic pathways in sheep horn remain unclear. In this study, to clarify the gene expression profile of horn buds and investigate the key genes in horn bud formation, RNA-sequencing (RNA-seq) technology was utilized to investigate differential gene expression in the horn buds and adjacent forehead skin of Altay sheep fetuses. There were only 68 differentially expressed genes (DEGs) identified, consisting of 58 up-regulated genes and 10 down-regulated genes. RXFP2 was differentially up-regulated in the horn buds and had the highest significance (p-value = 7.42 × 10−14). In addition, 32 DEGs were horn-related genes identified in previous studies, such as RXFP2, FOXL2, SFRP4, SFRP2, KRT1, KRT10, WNT7B, and WNT3. Further, Gene Ontology (GO) analysis showed that the DEGs were mainly enriched with regard to growth, development, and cell differentiation. Pathway analysis revealed that the Wnt signaling pathway may be responsible for horn development. Further, through combining the protein–protein interaction networks of the DEGs, it was found that the top five hub genes, namely, ACAN, SFRP2, SFRP4, WNT3, and WNT7B, were also associated with horn development. Our results suggest that only a few key genes, including RXFP2, are involved in bud formation. This study not only validates the expression of candidate genes identified at the transcriptome level in previous studies but also provides new possible marker genes for horn development, which may promote our understanding of the genetic mechanisms of horn formation.

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Section: Discussionmentioning

confidence: 99%

Identification of Critical Genes for Ovine Horn Development Based on Transcriptome during the Embryonic Period

Luan

Wang

et al. 2023

Biology

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“…This cleavage process produces CTF2, facilitated by γ-secretase, enhancing the transcriptional activity of β-catenin and cyclin D1. Consequently, this inhibits the G1/S transition, ultimately inducing the delamination of NCCs [31]. However, the connection between BMPs and WNT is more complex.…”

Section: Post-emt Genes and Regulationmentioning

confidence: 99%

Clinical and Genetic Correlation in Neurocristopathies: Bridging a Precision Medicine Gap

Chatzi,

Kyriakoudi,

Dermitzakis

et al. 2024

JCM

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Neurocristopathies (NCPs) encompass a spectrum of disorders arising from issues during the formation and migration of neural crest cells (NCCs). NCCs undergo epithelial–mesenchymal transition (EMT) and upon key developmental gene deregulation, fetuses and neonates are prone to exhibit diverse manifestations depending on the affected area. These conditions are generally rare and often have a genetic basis, with many following Mendelian inheritance patterns, thus making them perfect candidates for precision medicine. Examples include cranial NCPs, like Goldenhar syndrome and Axenfeld–Rieger syndrome; cardiac–vagal NCPs, such as DiGeorge syndrome; truncal NCPs, like congenital central hypoventilation syndrome and Waardenburg syndrome; and enteric NCPs, such as Hirschsprung disease. Additionally, NCCs’ migratory and differentiating nature makes their derivatives prone to tumors, with various cancer types categorized based on their NCC origin. Representative examples include schwannomas and pheochromocytomas. This review summarizes current knowledge of diseases arising from defects in NCCs’ specification and highlights the potential of precision medicine to remedy a clinical phenotype by targeting the genotype, particularly important given that those affected are primarily infants and young children.

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“…There are studies that describe how the highly conserved Wnt signaling pathway regulates the development and differentiation of the neural crest cells during embryogenesis. When Wnt signaling pathway is inhibited, it induces apoptosis and hinders proliferation and oncogenesis in all types of neuroblastic cells [ 43 ]. BORIS is a DNA-binding protein that recruits certain transcription factors and induces tumorigenesis.…”

Section: Wnt Signaling In Neuroblastomamentioning

confidence: 99%

Wnt/β-Catenin Signaling Pathway in Pediatric Tumors: Implications for Diagnosis and Treatment

Choudhary,

Singh,

Kashyap

et al. 2024

Children

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The evolutionarily conserved Wnt signaling has a significant and diverse role in maintaining cell homeostasis and tissue maintenance. It is necessary in the regulation of crucial biological functions such as embryonal development, proliferation, differentiation, cell fate, and stem cell pluripotency. The deregulation of Wnt/β-catenin signaling often leads to various diseases, including cancer and non-cancer diseases. The role of Wnt/β-catenin signaling in adult tumors has been extensively studied in literature. Although the Wnt signaling pathway has been well explored and recognized to play a role in the initiation and progression of cancer, there is still a lack of understanding on how it affects pediatric tumors. This review discusses the recent developments of this signaling pathway in pediatric tumors. We also focus on understanding how different types of variations in Wnt signaling pathway contribute to cancer development and provide an insight of tissue specific mutations that lead to clinical progression of these tumors.

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Neural crest cells development and neuroblastoma progression: Role of Wnt signaling

Cited by 4 publications

References 206 publications

Identification of Critical Genes for Ovine Horn Development Based on Transcriptome during the Embryonic Period

Identification of Critical Genes for Ovine Horn Development Based on Transcriptome during the Embryonic Period

Clinical and Genetic Correlation in Neurocristopathies: Bridging a Precision Medicine Gap

Wnt/β-Catenin Signaling Pathway in Pediatric Tumors: Implications for Diagnosis and Treatment

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