Neural correlates of visuospatial working memory in attention-deficit/hyperactivity disorder and healthy controls

Ewijk, Hanneke van; Weeda, Wouter D.; Heslenfeld, Dirk J.; Luman, Marjolein; Hartman, Catharina A.; Hoekstra, Pieter J.; Faraone, Stephen V.; Franke, Barbara; Buitelaar, Jan K.; Oosterlaan, Jaap

doi:10.1016/j.pscychresns.2015.07.003

Cited by 33 publications

(26 citation statements)

References 54 publications

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“…Most studies on ADHD focus on clarifying whether this disorder is an executive function disorder and on identifying which executive function is deficient [2][3][4][5][6][7]. However, research on the relationship between tactile perception, praxis, inhibitory control, and impulsivity in ADHD children is scarce [10].…”

Section: Discussionmentioning

confidence: 99%

“…Attention deficit hyperactivity disorder (ADHD) is characterized by three main symptoms: inattention, hyperactivity, and impulsivity [1]. Most studies about ADHD have focused on determining whether ADHD is an executive function disorder and concluded that the key deficit of ADHD is the inhibitory control and cognitive impulsivity [2][3][4][5][6][7]. Recent research has focused on the role of motor circuits and sensory processing on the pathophysiology of ADHD [8][9][10][11][12][13], showing that the somatosensory cortex is thinner in children with ADHD.…”

Section: Introductionmentioning

confidence: 99%

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Tactile Discrimination, Praxis and Cognitive Impulsivity in ADHD Children: A Cross-Sectional Study

Ayuso

Maciver

Richmond

et al. 2020

IJERPH

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Background: The study of attention deficit hyperactivity disorder (ADHD) has traditionally focused on deficit of inhibitory control and cognitive impulsivity. However, the pathophysiology of ADHD has also been associated with the somatosensory cortex. The aim of this study was to explore if there were differences in tactile discrimination and praxis between neurotypical and ADHD children and whether these differences could be explained by cognitive impulsivity. Methods: A cross-sectional study was conducted. The sample comprised 74 children aged 7 to 11 years divided in two groups: 43 with neurotypical development, 31 with ADHD. To assess tactile discrimination, the finger localization and the graphestesia tests were used. Praxis was assessed with the Kaufman Assesment Battery for Children (K-ABC) hand movement subtest, the action program and the Zoo Map subtests of the Behavioral Assessment of Dysexecutive Syndrome, and the complex figure of Rey–Osterrieth test (ROCF). Cognitive impulsivity was assessed using the Magallanes Computerized Impulsivity Scale test (EMIC). Results: Children with ADHD showed greater cognitive impulsivity (p = 0.038) and scored lower in Zoo Map (p = 0.023) and hand-movement subtests (p = 0.002), and in ROCF test (p = 0.004). Differences in praxis skills still remained after controlling by gender and cognitive impulsivity. Conclusion: Praxis deficit might have repercussions not only on the characterization of ADHD but also on its treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tactile Discrimination, Praxis and Cognitive Impulsivity in ADHD Children: A Cross-Sectional Study

Ayuso

Maciver

Richmond

et al. 2020

IJERPH

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“…This specific area has not been previously reported in meta-analyses of functional or structural MRI studies restricted to adults with ADHD, although it was reported in two meta-analyses combining fMRI studies in children and adults (8;9). Additionally, individual studies found alterations in pars opercularis of IFG both structurally [thinner cortex (75)] and functionally [reduced activation with low memory load and increased activation with high memory load (76)] in children with ADHD. Our results provide novel meta-analytic evidence supporting pars opercularis involvement in the pathophysiology of ADHD in adults.…”

Section: Discussionmentioning

confidence: 99%

Functional Decoding and Meta-analytic Connectivity Modeling in Adult Attention-Deficit/Hyperactivity Disorder

Cortese

Eickhoff

D’Acunto

et al. 2016

Biological Psychiatry

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Background Task-based fMRI studies of adult Attention-Deficit/Hyperactivity Disorder (ADHD) have revealed various ADHD-related dysfunctional brain regions, with heterogeneous findings across studies. Here, we used novel meta-analytic data-driven approaches to characterize the function and connectivity profile of ADHD-related dysfunctional regions consistently detected across studies. Methods We first conducted an activation likelihood estimation (ALE) meta-analysis of 24 task-based fMRI studies in adults with ADHD. Each ADHD-related dysfunctional region resulting from the ALE meta-analysis was then analyzed using functional decoding based on ~7,500 fMRI experiments in the BrainMap database. This approach allows mapping brain regions to functions not necessarily tested in individual studies, thus suggesting possible novel functions for those regions. Additionally, ADHD-related dysfunctional regions were clustered based on their functional co-activation profiles across all the experiments stored in BrainMap (meta-analytic connectivity modeling). Results ADHD-related hypoactivation was found in left putamen, left inferior frontal gyrus (pars opercularis), left temporal pole, and right caudate. Functional decoding mapped the left putamen and the left temporal lobe to cognitive aspects of music perception/reproduction and language semantics, respectively; both these regions clustered together based on their meta-analytic functional connectivity. Left inferior gyrus mapped to executive function tasks; right caudate mapped both to executive functions tasks and music-related processes. Conclusions Our study provides meta-analytic support to the hypothesis that, in addition to well-known deficits in typical executive functions, impairment in processes related to music perception/reproduction and language semantics may be involved in the pathophysiology of adult ADHD.

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“…In the current analyses, we use MRI data from healthy control participants only (initial N = 385) of the NeuroIMAGE sample ( Rhein et al, 2015 ) who each performed at least one of the following tasks during fMRI scanning: response inhibition (Stop Signal Task (STOP), ( Logan et al, 1984 , Rhein et al, 2015 , van Rooij et al, 2015 )), reward processing (REWARD, ( Hoogman et al, 2011 , Knutson et al, 2001 , Rhein et al, 2015 , von Rhein et al, 2015 )), spatial working memory (WM, ( van Ewijk et al, 2015 , Klingberg et al, 2002 , McNab et al, 2008 , Rhein et al, 2015 )). In addition, each participant completed a resting state (RS) fMRI session.…”

Section: Methodsmentioning

confidence: 99%

Assessing age-dependent multi-task functional co-activation changes using measures of task-potency

Chauvin

Mennes

Buitelaar

et al. 2018

Developmental Cognitive Neuroscience

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Neural correlates of visuospatial working memory in attention-deficit/hyperactivity disorder and healthy controls

Cited by 33 publications

References 54 publications

Tactile Discrimination, Praxis and Cognitive Impulsivity in ADHD Children: A Cross-Sectional Study

Tactile Discrimination, Praxis and Cognitive Impulsivity in ADHD Children: A Cross-Sectional Study

Functional Decoding and Meta-analytic Connectivity Modeling in Adult Attention-Deficit/Hyperactivity Disorder

Assessing age-dependent multi-task functional co-activation changes using measures of task-potency

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