Neural correlates of verbal recognition memory in obese adults with and without major depressive disorder

Restivo, Maria; Hall, Geoffrey B.; Frey, Benício N.; McKinnon, Margaret C.; Taylor, Valerie H.

doi:10.1002/brb3.1848

Cited by 5 publications

(4 citation statements)

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“…The ACC is engaged in multiple cognitive processes including anticipatory control (Aarts et al., 2008 ), anticipation of conflict monitoring (Sohn et al., 2007 ), prediction of future states based on chosen actions (Akam et al., 2021 ), and conflict monitoring (Barch et al., 2001 ; Botvinick et al., 2001 ). It shows greater activation in obese individuals with major depressive disorder compared to those without major depressive disorder during pleasantness rating of neutral words (Restivo et al., 2020 ). Our findings of distinct activation patterns in these regions for individuals with DD versus HC suggests that different brain mechanisms may underlie behaviors leading to overweight/obesity in these groups.…”

Section: Discussionmentioning

confidence: 99%

“…Many of these same regions (e.g., the ACC, insula, amygdala, prefrontal cortices) showed aberrant activation patterns in individuals with DD versus HC (Hamilton et al., 2012 ; Li & Wang, 2020 ) with the insula showing distinct activation patterns as a function of appetite decrease/increase in individuals with DD in response to the pictures of food (Simmons et al., 2016 ; Simmons et al., 2020 ). The precuneus and ACC showed stronger activation in obese individuals with DD and obese HC during word pleasantness judgments (Restivo et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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The interaction between depression diagnosis and BMI is related to altered activation pattern in the right inferior frontal gyrus and anterior cingulate cortex during food anticipation

et al. 2022

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Background Depression and overweight/obesity often cooccur but the underlying neural mechanisms for this bidirectional link are not well understood. Methods In this functional magnetic resonance imaging study, we scanned 54 individuals diagnosed with depressive disorders (DD) and 48 healthy controls (HC) to examine how diagnostic status moderates the relationship between body mass index (BMI) and brain activation during anticipation and pleasantness rating of food versus nonfood stimuli. Results We found a significant BMI‐by‐diagnosis interaction effect on activation in the right inferior frontal gyrus (RIFG) and anterior cingulate cortex (ACC) during food versus nonfood anticipation (p < .0125). Brain activation in these regions was greater in HC with higher BMI than in HC with lower BMI. Individuals with DD showed an opposite pattern of activation. Structural equation modeling revealed that the relationship between BMI, activation in the RIFG and ACC, and participants’ desire to eat food items shown in the experiment depended on the diagnostic status. Conclusions Considering that food anticipation is an important component of appetitive behavior and that the RIFG and ACC are involved in emotion regulation, response inhibition and conflict monitoring necessary to control this behavior, we propose that future clinical trials targeting weight loss in DD should investigate whether adequate mental preparation positively affects subsequent food consumption behaviors in these individuals.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The interaction between depression diagnosis and BMI is related to altered activation pattern in the right inferior frontal gyrus and anterior cingulate cortex during food anticipation

et al. 2022

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“…Previous studies have shown that the insula, posterior fusiform gyrus, and lateral orbitofrontal cortex activated in response to food vs. non-food items (56,57). The only recent study comparing obese individuals with and without major depressive disorder found stronger activation in the precuneus and anterior cingulate cortex in the former individuals during judging neutral words as pleasant or unpleasant (15). In addition, greater activation in insula, striatum and fusiform gyrus predicted less successful longitudinal outcome in the weight maintenance program (58).…”

Section: Discussionmentioning

confidence: 99%

“…Although understanding the neurobiological factors contributing to the interplay between depression and obesity is critical for development of prevention and intervention treatments, to date, only one neuroimaging study has focused on comparing individuals with obesity vs. those with obesity and major depressive disorder (15). That study found that individuals with obesity and depression had stronger activation in the precuneus and anterior cingulate cortex compared to obese individuals without depression during pleasant/unpleasant judgments of words.…”

Section: Introductionmentioning

confidence: 99%

The interaction between lifetime depression severity and BMI is related to altered activation pattern in the right inferior frontal gyrus during food anticipation

Manelis

Halchenko

Satz

et al. 2021

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Background: Depression and obesity often co-occur but the underlying neural mechanisms for this bidirectional link are not well understood. Using fMRI, we examined how the relationship between Body Mass Index (BMI) and dimensional lifetime depression severity was associated with brain activation during food anticipation and pleasant/unpleasant rating. Methods: 90 participants (48 healthy controls, 42 with unipolar depression (UD), 69 female, age=28.5(6.6)) were fMRI-scanned while performing the Food and Object Cued Encoding task consisting of food/object anticipation and food/object pleasant/unpleasant rating phases. Results: The analysis across all participants revealed a significant BMI-by-lifetime depression severity interaction on RIFG activation during food anticipation (p<0.0125). Most symptomatic and overweight/obese individuals with UD showed decreased right inferior frontal gyrus (RIFG) activation during food anticipation, while less symptomatic and/or normal-weight individuals with UD showed increased RIFG activation during food anticipation. RIFG activation during food anticipation was negatively correlated with RIFG activation during pleasant/unpleasant rating (r= -0.63, p<0.001). Individuals with UD who showed higher RIFG activation for food items during pleasant/unpleasant rating reported liking or wanting those food items less than those with lower RIFG activation (p<0.05). Conclusions: The IFG is involved in emotion regulation and response inhibition necessary to control appetitive behavior. Greater RIFG activation during pleasant/unpleasant rating of food coupled with low ratings of food liking and wanting could be associated with inhibition of cognitive and emotional response to food in UD. This process may be cognitively challenging and stressful thus putting affected individuals with UD at risk for weight gain and worsening of depression.

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Altered neural correlates of episodic memory for food and non-food cues in females with overweight/obesity

et al. 2022

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Neural correlates of verbal recognition memory in obese adults with and without major depressive disorder

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 5 publications

References 50 publications

The interaction between depression diagnosis and BMI is related to altered activation pattern in the right inferior frontal gyrus and anterior cingulate cortex during food anticipation

The interaction between depression diagnosis and BMI is related to altered activation pattern in the right inferior frontal gyrus and anterior cingulate cortex during food anticipation

The interaction between lifetime depression severity and BMI is related to altered activation pattern in the right inferior frontal gyrus during food anticipation

Altered neural correlates of episodic memory for food and non-food cues in females with overweight/obesity

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