Neural correlates of tinnitus related distress: An fMRI-study

Golm, Dennis; Schmidt‐Samoa, Carsten; Dechent, Peter; Kröner‐Herwig, Birgit

doi:10.1016/j.heares.2012.03.003

Cited by 94 publications

(90 citation statements)

References 83 publications

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“…Other studies [21][22][23] demonstrated that nonauditory brain regions might also contribute to the perception or severity of tinnitus. Because the neural mechanisms of tinnitus make the condition a good candidate for suppression by rTMS, this procedure has been investigated as a potential treatment for chronic tinnitus by several different groups of researchers around the world (Theodoroff and Folmer 12 provide a review).…”

Section: Mechanisms Of Tinnitusmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation Treatment for Chronic Tinnitus

Folmer

Theodoroff

Casiana

et al. 2015

JAMA Otolaryngol Head Neck Surg

131

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Section: Mechanisms Of Tinnitusmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation Treatment for Chronic Tinnitus

Folmer

Theodoroff

Casiana

et al. 2015

JAMA Otolaryngol Head Neck Surg

131

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“…To learn more about the existence of tinnitus-related neural subnetworks as delineated by DeRidder and et al [9], it is not sufficient simply to expose distinct areas without a complementary analysis of effective structural connectivity. To this end, Golm and collaborators [18] raise the question of how tinnitus-specific a 'network' made up of a sample of typical candidate regions may indeed be? Yet another question raised may be whether an increase or a decrease of CT should be considered advantageous or detrimental.…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

“…One important issue relates to the heterogeneity of the TI population which may be subdivided into a number of various tinnitus subtypes [6,13]. A relevant question in this context pertains to the role that one cardinal feature, namely emotional distress, 1 plays in tinnitus subtyping [16,17,18,19]. Recent research has shown that there is a high variability among people with 25 tinnitus in the degree to which they are emotionally affected by the chronic noise [20].…”

Section: Introductionmentioning

confidence: 99%

Differential tinnitus-related neuroplastic alterations of cortical thickness and surface area

et al. 2016

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Structural neuroimaging techniques have been used to identify cortical and subcortical regions constituting the neuroarchitecture of tinnitus. One recent investigation used voxel-based morphometry (VBM) to analyze a sample of tinnitus patients (TI, n=257) [1]. A negative relationship between individual distress and cortical volume (CV) in bilateral auditory regions was observed. However, CV has meanwhile been identified as a neuroanatomical measurement that confounds genetically distinct neuroanatomical traits, namely cortical thickness (CT) and cortical surface area (CSA). We performed a re-analysis of the identical sample using the automated FreeSurfer surface-based morphometry (SBM) approach [2]. First, we replicated the negative correlation between tinnitus distress and bilateral supratemporal gray matter volume. Second, we observed a negative correlation for CSA in the left peri-auditory cortex and anterior insula. Furthermore, we noted a positive correlation between tinnitus duration and CT in the left peri-auditory cortex as well as a negative correlation in the subcallosal anterior cingulate, a region collated to the serotonergic circuit and germane to inhibitory functions. In short, the results elucidate differential neuroanatomical alterations of CSA and CT for the two independent tinnitus-related psychological traits distress and duration. Beyond this, the study provides further evidence for the distinction and specific susceptibility of CSA and CT within the context of neuroplasticity of the human brain. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A negative relationship between individual distress and cortical volume (CV) in bilateral auditory regions was observed. However, CV has meanwhile been identified as a neuroanatomical measurement that confounds genetically distinct neuroanatomical traits, namely cortical thickness (CT) and cortical surface area (CSA). We performed a re-analysis of the identical sample using the automated FreeSurfer surface-based morphometry (SBM) approach [2]. First, we replicated the negative correlation between tinnitus distress and bilateral supratemporal gray matter volume. Second, we observed a negative correlation for CSA in the left peri-auditory cortex and anterior insula. Furthermore, we noted a positive correlation between tinnitus duration and CT in the left peri-auditory cortex as well as a negative correlation in the subcallosal anterior cingulate, a region collated to the serotonergic circuit and germane to inhibitory functions. In short, the results elucidate differential neuroanatomical alterations of CSA and CT for the two independent...

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“…Ineffective inhibition during auditory processing, neuronal plasticity in the auditory cortex, and involvement of the limbic system in the processing of negatively valued acoustic stimuli including tinnitus sound as well as changing connectivity between the brain areas were implied as mechanism for such an activation [Andersson et al, 2000;Georgiewa et al, 2012;Golm et al, 2013;Leaver et al, 2011;Rauschecker et al, 2010;Seydell-Greenwald et al, 2012].…”

Section: Introductionmentioning

confidence: 99%

“…The Global Brain Model [Schlee et al, 2009] postulates activation of the auditory cortex by a frontalparietal-cingular network. This network involves the dorsolateral prefrontal cortex, orbitofrontal cortex, anterior cingular cortex and precuneus/posterior cingular cortex [De Ridder et al, 2011;Golm et al, 2013].…”

mentioning

confidence: 99%

Cerebral Processing of Emotionally Loaded Acoustic Signals by Tinnitus Patients

Georgiewa¹,

Szczepek

Rose³

et al. 2016

Audiol Neurotol

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This exploratory study determined the activation pattern in nonauditory brain areas in response to acoustic, emotionally positive, negative or neutral stimuli presented to tinnitus patients and control subjects. Ten patients with chronic tinnitus and without measurable hearing loss and 13 matched control subjects were included in the study and subjected to fMRI with a 1.5-tesla scanner. During the scanning procedure, acoustic stimuli of different emotional value were presented to the subjects. Statistical analyses were performed using statistical parametric mapping (SPM 99). The activation pattern induced by emotionally loaded acoustic stimuli differed significantly within and between both groups tested, depending on the kind of stimuli used. Within-group differences included the limbic system, prefrontal regions, temporal association cortices and striatal regions. Tinnitus patients had a pronounced involvement of limbic regions involved in the processing of chimes (positive stimulus) and neutral words (neutral stimulus), strongly suggesting improperly functioning inhibitory mechanisms that were functioning well in the control subjects. This study supports the hypothesis about the existence of a tinnitus-specific brain network. Such a network could respond to any acoustic stimuli by activating limbic areas involved in stress reactivity and emotional processing and by reducing activation of areas responsible for attention and acoustic filtering (thalamus, frontal regions), possibly reinforcing negative effects of tinnitus.

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Neural correlates of tinnitus related distress: An fMRI-study

Cited by 94 publications

References 83 publications

Repetitive Transcranial Magnetic Stimulation Treatment for Chronic Tinnitus

Repetitive Transcranial Magnetic Stimulation Treatment for Chronic Tinnitus

Differential tinnitus-related neuroplastic alterations of cortical thickness and surface area

Cerebral Processing of Emotionally Loaded Acoustic Signals by Tinnitus Patients

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