Neural correlates of the happy life: The amplitude of spontaneous low frequency fluctuations predicts subjective well-being

Kong, Feng; Hu, Siyuan; Wang, Xu; Song, Yiying; Liu, Jia

doi:10.1016/j.neuroimage.2014.11.033

Cited by 113 publications

(96 citation statements)

References 126 publications

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“…Thus, psychological resilience is a crucial factor for achieving a happy life. On the other hand, our finding concurs with those previously reporting the association of the OFC with life satisfaction (Kong et al , 2015a,c). Specifically, lower life satisfaction was related to smaller rGMV in the OFC/vmPFC (Kong et al , 2015a) and higher fALFF in the OFC (Kong et al , 2015c).…”

Section: Discussionsupporting

confidence: 93%

“…However, there’re still several problems needing further research. On one hand, as mentioned earlier, this study did not find any association of other PFC subregions, especially OFC with psychological resilience and life satisfaction (Liberzon and Sripada, 2008; Reynaud et al , 2013; Sekiguchi et al , 2015; Kong et al , 2015c). On the other hand, this study focused on only the cognitive component of subjective well-being, but it is generally known that subjective well-being includes a cognitive component (i.e.…”

Section: Introductionsupporting

confidence: 57%

“…spontaneous brain activity intensity) (Zou et al , 2008). Importantly, the ReHo/fALFF measures have been used to identify the neural marker of mental disorders (Cheng et al , 2012; Dutta et al , 2014; Liu et al , 2014) and uncover the neural basis of individual differences in behavior in normal populations (Tian et al , 2012; Zou et al , 2013; Kong et al , 2015c, 2016a,b, 2018; Xiang et al , 2016). In addition, previous studies have found that the ReHo/fALFF could successfully predict task-evoked activations and behavioral performance (Mennes et al , 2011; Yuan et al , 2013; Zou et al , 2013).…”

Section: Introductionmentioning

confidence: 99%

“…Importantly, some regions with the PFC related to psychological resilience (e.g. OFC and ACC) are also found to be implicated in subjective well-being (Van Reekum et al , 2007; Kong et al , 2015a,c,d, 2016a;). Notably, Kong et al (2015d) revealed that the ReHo in the ACC related to trait resilience could significantly predict the cognitive component of subjective well-being (i.e.…”

Section: Introductionmentioning

confidence: 99%

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The resilient brain: psychological resilience mediates the effect of amplitude of low-frequency fluctuations in orbitofrontal cortex on subjective well-being in young healthy adults

Kong

You

et al. 2018

Social Cognitive and Affective Neuroscience

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Psychological resilience reflects the capacity to bounce back from stress, which plays an important role in health and well-being. However, less is known about the neural substrate for psychological resilience and the underlying mechanism for how psychological resilience enhances subjective well-being in the healthy brain. To investigate these issues, we employed fractional amplitude of low-frequency fluctuations (fALFF) measured with resting-state fMRI in 100 young healthy adults. The correlation analysis found that higher psychological resilience was related to lower fALFF in the left orbitofrontal cortex (OFC), which is involved in reward-related processing and emotion regulation. Furthermore, the mediation analysis indicated that psychological resilience acted as a full mediator of the association between the fALFF in left OFC and subjective well-being indicators (i.e. life satisfaction and hedonic balance). Importantly, these results remained significant after controlling for the effect of gray matter volume and regional homogeneity in the region. Overall, the present study provides the further evidence for functional neural substrates of psychological resilience and reveals a potential mechanism that psychological resilience mediates the effect of spontaneous brain activity on subjective well-being.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The resilient brain: psychological resilience mediates the effect of amplitude of low-frequency fluctuations in orbitofrontal cortex on subjective well-being in young healthy adults

Kong

You

et al. 2018

Social Cognitive and Affective Neuroscience

Self Cite

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“…Since the anti-correlated relationship between the VAN and DMN was consistently found in the low-frequency range (<0.1 Hz) during states of resting as well as active tasks [39], perhaps the rate of such between-network alternation (oscillation) is around 10 seconds or longer per cycle. Interestingly, this anti-correlation oscillates at a rate similar to the rate of breathing that can induce respiratory sinus arrhythmia, a state of maximal coherence between breathing and heart rate variability that generates stress-reducing effects [40].…”

Section: Functional Dynamics Between Affect-object and Cognitive Contmentioning

confidence: 99%

Healing Dysfunctional Identity: Bridging Mind-Body Intervention to Brain Systems

Ho¹,

Nakamura²

2017

JBBS

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In this paper, we aim to use an innovative model to integrate applied work on a fast-acting mind-body intervention, Mind-Body Bridging (MBB), with theoretical work based on psychology and neuroscience. In an affect-object generative inference and regulation (AGIR) model, we propose that functional dynamics between two systems, the affect-object thought generation system and the cognitive control system, can guide an individual to achieve homeostasis within self and harmonious relationships with others. We used Neurosynth (www.neurosynth.org), an automated meta-analysis database, to identify potential brain substrates underlying the key components in the AGIR model. Based on the findings, some brain regions are implicated as the key cortical substrates in this model, corroborating our central hypothesis that a hallmark of mind-body wellbeing can be characterized as a low-frequency anti-correlantion between 1) the cognitive control system including the dorsal anterior/middle cingulate cortex, and 2) the affect-object thought generation system including the ventromedial prefrontal cortex and posterior cingulate cortex. MBB provides an efficient strategy for responding to and dissolving a fundamental problem that impairs mind-body wellbeing, i.e., unrealistic identity-grasping consisting of self-centered embodied expectations of self and others. We demonstrated how theoretical and applied work could be integrated by drawing evidence from the neuroscience literature to support the AGIR model, and then we applied the AGIR model to elucidate how MBB might work.

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Effects of STN‐DBS surgery on cerebral glucose metabolism and distribution of DAT in Parkinson's disease

et al. 2023

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Introduction: Parkinson's disease (PD) is a neurodegenerative disorder that affects millions of people worldwide. Subthalamic nucleus (STN) deep brain stimulation (DBS) has been shown to be an effective treatment for PD; however, the effects of this surgery on cerebral metabolism and presynaptic dopamine transporter (DAT) distribution are still being studied.Methods: In this study, we included 12 PD patients (6 male and 6 female) who underwent STN‐DBS surgery and had both 18F‐FDG and 11C‐CFT PET/CT imaging before and 1 year after the surgery. We used paired t‐tests to identify changes in cerebral metabolism and calculated PD‐related metabolic covariance pattern (PDRP) scores. We also assessed the uptake of 11C‐CFT in the striatum using striatal‐to‐occipital ratios (SORs).Results: One year after surgery, we observed significant reductions in tremor, rigidity, akinesia, postural instability/gait disturbance, and Unified Parkinson's Disease Rating Scale Part III scores (p < .01, p < .001, p < .001, p < .001, and p < .001, respectively). Hamilton Depression Rating Scale and quality of life (PDQ‐39 SI) were also significantly reduced (p < .05 and p < .01, respectively). The mean PDRP score decreased by 37% from 13.0 ± 6.6 to 8.2 ± 7.9 after STN‐DBS surgery (p < .05). We observed decreased 18F‐FDG uptake in several areas, including the temporal lobe (BA22), thalamus, putamen, and cingulate gyrus (BA24), whereas it was increased in the supplementary motor area, postcentral gyrus, lingual gyrus, and precuneus (p < .05). SORs of 11C‐CFT in the bilateral caudate nucleus and ipsilateral posterior putamen were significantly decreased compared to preoperative levels (p < .05).Conclusion: Our findings suggest that STN‐DBS surgery modifies the metabolic network of PD patients and improves motor symptoms, depression, and quality of life. However, it does not prevent the decrease of DAT in striatal areas.

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Neural correlates of the happy life: The amplitude of spontaneous low frequency fluctuations predicts subjective well-being

Cited by 113 publications

References 126 publications

The resilient brain: psychological resilience mediates the effect of amplitude of low-frequency fluctuations in orbitofrontal cortex on subjective well-being in young healthy adults

The resilient brain: psychological resilience mediates the effect of amplitude of low-frequency fluctuations in orbitofrontal cortex on subjective well-being in young healthy adults

Healing Dysfunctional Identity: Bridging Mind-Body Intervention to Brain Systems

Effects of STN‐DBS surgery on cerebral glucose metabolism and distribution of DAT in Parkinson's disease

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