Neural correlates of response inhibition in children with attention-deficit/hyperactivity disorder: A controlled version of the stop-signal task

Janssen, Tieme W. P.; Heslenfeld, Dirk J.; Mourik, Rosa van; Logan, Gordon D.; Oosterlaan, Jaap

doi:10.1016/j.pscychresns.2015.07.007

Cited by 35 publications

(23 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings, consistent with other studies of adults (Bekker et al 2005), demonstrated that differences between ADHD and non-ADHD participants in SSRT reflected group differences in the stop signal delay, but not in mean reaction time, consistent with the notion that SSRT indexes inhibition deficits in this group. Response inhibition deficits (as indexed via the stop-signal paradigm) have been described in multiple studies and are frequently used in conjunction with other methods to identify relevant neural pathways associated with the disorder (Janssen et al 2015; Lipszyc and Schachar 2010; Nigg et al 2002). However, future work with ADHD populations across the developmental spectrum will benefit by vetting the validity of SSRT as an index of response inhibition.…”

Section: Discussionmentioning

confidence: 99%

Sluggish Cognitive Tempo Symptoms Contribute to Heterogeneity in Adult Attention-Deficit Hyperactivity Disorder

Kamradt

Momany

Nikolas

2017

J Psychopathol Behav Assess

View full text Add to dashboard Cite

Attention-deficit hyperactivity disorder (ADHD) persists into adulthood in over 50% of cases, although its associated symptom profiles, comorbid problems, and neuropsychological deficits change substantially across development. Sluggish cognitive tempo (SCT) symptoms may contribute to associations between ADHD and comorbid problems and may partially explain the substantial heterogeneity observed in its correlates. 349 adults aged 18–38 years (M = 23.2, SD = 4.5, 54.7% male, 61.03% with ADHD) completed a multi-informant diagnostic procedure and a comprehensive neuropsychological battery. Adults with ADHD (n = 213) were retained for analyses. Latent class analyses (LCA) revealed three profiles of SCT symptoms among those with ADHD, which we classified as minimal, moderate, or severe SCT. Multiple analysis of covariance (MANCOVA) revealed significant differences among these profiles, which remained when controlling for persistence of ADHD symptoms and sex. In general, adults with ADHD combined with SCT symptoms (moderate and severe) had significantly more symptoms of anxiety, depression, and persistent inattention, and had more severe professional and relational impairment compared to ADHD adults without SCT. Compared to those with moderate or minimal SCT symptoms, the severe SCT group had the most symptoms of depression and internalizing disorders, and the most impairment in the domain of daily responsibility. No significant differences based on externalizing symptoms emerged when controlling for sex and persistence of inattention symptoms, suggesting the moderate and severe SCT groups do not simply reflect more symptoms. Moreover, follow-up mediation analyses revealed that SCT might at least partially explain the heterogeneity in ADHD. Findings have implications for refinement of etiological conceptualization, assessment methods, and intervention strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

Sluggish Cognitive Tempo Symptoms Contribute to Heterogeneity in Adult Attention-Deficit Hyperactivity Disorder

Kamradt

Momany

Nikolas

2017

J Psychopathol Behav Assess

View full text Add to dashboard Cite

show abstract

“…Numerous studies have used fMRI to assess response inhibition in ADHD, which is frequently impaired in that disorder (Barkley, ; Nigg, ; Pliszka et al., ) (see Table for a review). Studies using GNG tasks have found lower levels of activation in children and adolescents with ADHD in the regions of the inferior frontal cortex that are typically activated during the NoGo trials in normal controls (Hart et al., ; Janssen et al., ; Morein‐Zamir et al., ; Rubia et al., ). In an adult study that used a GNG task, amount of activation in the inferior frontal cortex was negatively related to severity of the patient's ADHD behavioral problems (Cubillo et al., ).…”

Section: Summary Of Neuroimaging and Erp Studies Of Response Inhibitimentioning

confidence: 99%

Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol

Kodali

Jacobson

Lindinger

et al. 2017

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

Background Response inhibition is a distinct aspect of executive function that is frequently impaired in children with fetal alcohol spectrum disorders (FASD). We used a Go/NoGo (GNG) task in a functional MRI (fMRI) protocol to investigate differential activation of brain regions in the response inhibition network in children diagnosed with full or partial fetal alcohol syndrome (FAS/PFAS), compared with healthy controls. Methods A rapid, event-related task with 120 Go and 60 NoGo trials was used to study children aged 8–12 years—8 with FAS/PFAS, 17 controls. Letters were projected sequentially, with Go and NoGo trials randomly interspersed across the task. BOLD signal in the whole brain was contrasted for the correct NoGo minus correct Go trials between the FAS/PFAS and control groups. Results Compared to the FAS/PFAS group, controls showed greater activation of the inferior frontal and anterior cingulate network linked to response inhibition in typically developing children. By contrast, the FAS/PFAS group showed greater BOLD response in dorsolateral prefrontal cortex (dlPFC) and other middle prefrontal regions, suggesting compensation for inefficient function of pathways that normally mediate inhibitory processing. All group differences were significant after control for potential confounding variables. None of the effects of prenatal alcohol exposure on activation of the regions associated with response inhibition were attributable to the effects of this exposure on IQ. Conclusions This is the first FASD GNG study in which all participants in the exposed group met criteria for a diagnosis of full fetal alcohol syndrome (FAS) or partial FAS (PFAS). Although FASD is frequently co-morbid with attention deficit hyperactivity disorder (ADHD), the pattern of brain activation seen in these disorders differs, suggesting that different neural pathways mediate response inhibition in FASD and that different interventions for FASD are, therefore, warranted.

show abstract

“…Specifically, the dACC strongly contributes to the pathophysiology of ADHD (for review see: Bush, 2011). Those with ADHD also have greater insula reactivity during affective processing (Wilbertz et al, 2017) and show insula and dACC hypo-activity during inhibitory tasks (Janssen et al, 2015). Insula function also plays a key role in nicotine use in human (Dias et al, 2006; Naqvi et al, 2007; Janes et al, 2010, 2015, 2017), and rodent models (Forget et al, 2010; Pushparaj et al, 2013), while dACC function and neurochemistry has been linked to difficulty ignoring smoking cues (Luijten et al, 2012; Janes et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Salience network coupling is linked to both tobacco smoking and symptoms of attention deficit hyperactivity disorder (ADHD)

Janes

Gilman

Frederick

et al. 2018

Drug and Alcohol Dependence

View full text Add to dashboard Cite

The greater ASRS scores in nicotine dependent individuals is in line with existent literature and the stronger dACC-AI coupling in smokers further supports the role of this network in nicotine dependence. The significant association between dACC-AI coupling and ASRS suggests that intra-SN coupling strength may impact neurocognitive functioning associated with both ADHD symptoms and nicotine dependence.

show abstract

Neural correlates of response inhibition in children with attention-deficit/hyperactivity disorder: A controlled version of the stop-signal task

Cited by 35 publications

References 46 publications

Sluggish Cognitive Tempo Symptoms Contribute to Heterogeneity in Adult Attention-Deficit Hyperactivity Disorder

Sluggish Cognitive Tempo Symptoms Contribute to Heterogeneity in Adult Attention-Deficit Hyperactivity Disorder

Differential Recruitment of Brain Regions During Response Inhibition in Children Prenatally Exposed to Alcohol

Salience network coupling is linked to both tobacco smoking and symptoms of attention deficit hyperactivity disorder (ADHD)

Contact Info

Product

Resources

About