Neural correlates of plasma acylated ghrelin level in individuals with major depressive disorder

Matsuo, Koji; Nakano, Masayuki; Nakashima, Mami; Watanuki, Toshio; Egashira, Kazuteru; Matsubara, Takehiro; Watanabe, Yoshifumi

doi:10.1016/j.brainres.2012.07.027

Cited by 32 publications

(21 citation statements)

References 40 publications

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“…Similar results concerning high ghrelin levels in depression have been reported in previous studies 14,24. Some other studies have found decreased or unchanged ghrelin levels in depressive patients, inconsistent with our results 20,21,22,23. Although the finding of increased serum ghrelin level is inconsistent with some previous studies, it is in agreement with data on the relation between ghrelin and stress and depression.…”

Section: Discussioncontrasting

confidence: 95%

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Serum Ghrelin and Leptin Levels in Patients with Depression and the Effects of Treatment

Özsoy

Beşirli

Abdülrezzak

et al. 2014

Psychiatry Investig

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ObjectiveGhrelin and leptin, appetite-regulating hormones, play a role in mood regulation. Current data about the relation between leptin/ghrelin and depression are still controversial. This study aimed to investigate serum leptin and ghrelin levels in patients with depression and the effects of treatment on these levels.MethodsSerum ghrelin and leptin levels were measured before and after treatment with antidepressant drugs and/or electroconvulsive therapy in 28 patients with depression and once in 21 healthy controls.ResultsSerum ghrelin levels of the patients were high in the pre-treatment. After the treatment, ghrelin levels were not different from those of the controls. We found no difference in serum levels of leptin between the patients and controls and no change with treatment. body mass index of the patients increased after the treatment especially in the drug-treated group.ConclusionThe present study found increased serum ghrelin levels in depressive patients and normalization with improving of depression but no alteration in leptin levels.

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Section: Discussioncontrasting

confidence: 95%

“…A study reported low ghrelin levels in depressive patients 20. However, many others suggested no difference in ghrelin levels between depressive patients and healthy controls 21,22,23. Nevertheless, some studies found high serum ghrelin levels in patients with major depression 14,24.…”

Section: Introductionmentioning

confidence: 99%

Serum Ghrelin and Leptin Levels in Patients with Depression and the Effects of Treatment

Özsoy

Beşirli

Abdülrezzak

et al. 2014

Psychiatry Investig

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“…In human studies too contrasting findings were reported. Some researches did not find any differences in ghrelin levels between patients with major depression and controls [62,78,79] while other researchers suggested that plasma ghrelin levels as well as preproghrelin mRNA levels are elevated in conditions of stress [77,80] . Ozsoy et al [81] , for example, found higher levels in serum ghrelin levels in depressive patients, than in controls and they also found that high serum ghrelin levels were normalized by treatment.…”

Section: Ref Findingsmentioning

confidence: 98%

“…Rouach et al [80] High in patients with binge-eating disorders Schanze et al [62] No difference Kluge et al [78] No difference Barim et al [68] Low Matsuo et al [79] No difference Ishitobi et al [84] High in non-responders with MDD Ozsoy et al [81] High Treatment and ghrelin levels Schmid et al [83] Decrease with mirtazapine MDD: Major depressive disorder.…”

Section: Ref Findingsmentioning

confidence: 99%

Mood disorders: A potential link between ghrelin and leptin on human body?

Zarouna

Wozniak

2015

WJEM

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Leptin and ghrelin are two hormones associated with multiple physiological functions, especially energy balance. Leptin is an adipocyte-secreted hormone discovered in 1950 and ghrelin which was found in 1999, is a peptide hormone produced and secreted in the stomach. A number of previous studies showed that these hormones could be associated with different types of mood disorders. The results of previous studies, nevertheless, are confounded by diverse sample selection and different methodologies. A search for related articles in the PubMed database was attempted. The search covered studies, reports, reviews and editorials published in the last ten years. Older references served as auxiliary sources for comparison purposes. However, due to the different results of the studies, there is a need for more investigation in order to establish the exact biochemical mechanisms that are responsible for these diseases and ghrelin's and leptin's effects on mood. Core tip: Mood disorders are affecting a major amount of the world population. Considering the multiple factors that are contributing in the development of mood disorders, this review emphasizes on the role of leptin and ghrelin hormones. These two hormones have a key role in energy balance but they also have an effect on other physiological functions too, therefore we emphasize on the recent findings which raise a potential link between the hormones and the disorders of mood.

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“…Barim et al, 2009) or no difference between MDD and control participants observed (e.g. Kluge et al, 2009;Lawson et al, 2011;Matsuo et al, 2012). Whether ghrelin levels differ by melancholic/atypical subtype is currently unclear, however due to its role in stimulating appetite levels (e.g.…”

Section: Introductionmentioning

confidence: 99%

Weight gain in Major Depressive Disorder: Linking appetite and disordered eating to leptin and ghrelin.

Mills

Larkin

Deng

et al. 2019

Psychiatry Research

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Major Depressive Disorder (MDD) involves changes in appetite and weight, with a subset of individuals at an increased risk of weight gain. Pathways to weight gain may include appetite disturbances, excess eating, and dysregulation of appetite hormones. However, little research has simultaneously examined relationships between hormones, eating behaviours and MDD symptoms. Plasma ghrelin and leptin, biometrics, eating behaviours and psychopathology were compared between depressed (n = 60) and control (n = 60) participants. Depressed participants were subcategorised into those with increased or decreased appetite/ weight for comparison by subtype. The Dutch Eating Behaviours Questionnaire and Yale Food Addiction Scale measured eating behaviours. Disordered eating was higher in MDD than controls, in females than males, and in depressed individuals with increased, compared to decreased, appetite/weight. Leptin levels were higher in females only. Leptin levels correlated positively, and ghrelin negatively, with disordered eating. The results provide further evidence for high levels of disordered eating in MDD, particularly in females. The correlations suggest that excessive eating in MDD is significantly linked to appetite hormones, indicating that it involves physiological, rather than purely psychological, factors. Further, longitudinal, research is needed to better understand whether hormonal factors play a causal role in excessive eating in MDD.

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Neural correlates of plasma acylated ghrelin level in individuals with major depressive disorder

Cited by 32 publications

References 40 publications

Serum Ghrelin and Leptin Levels in Patients with Depression and the Effects of Treatment

Serum Ghrelin and Leptin Levels in Patients with Depression and the Effects of Treatment

Mood disorders: A potential link between ghrelin and leptin on human body?

Weight gain in Major Depressive Disorder: Linking appetite and disordered eating to leptin and ghrelin.

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