Neural correlates of maternal separation in rhesus monkeys

Rilling, James K.; Winslow, James; O’Brien, Derek; Gutman, David; Hoffman, John M.; Kilts, Clinton D.

doi:10.1016/s0006-3223(00)00977-x

Cited by 101 publications

(61 citation statements)

References 38 publications

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“…It is of note that monkey and human infants indeed demonstrate similar acute behavioral and physiological reactions to separations . Interestingly, infant monkeys show robust activation of the right and deactivation of the left frontal cortex in reaction to maternal separation, and the extent of change is corraleted with cortisol increases (Rilling et al, 2001). A similar pattern has been observed in rhesus monkeys with fearful temperament (Kalin et al, 1998).…”

Section: Neurobiology Of Elssupporting

confidence: 62%

Importance of Studying the Contributions of Early Adverse Experience to Neurobiological Findings in Depression

Heim

Plotsky

Nemeroff

2004

Neuropsychopharmacol

471

339

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Almost four decades of intensive research have sought to elucidate the neurobiological bases of depression. Epidemiological studies have revealed that both genetic and environmental factors contribute to the risk for depression. Adverse early-life experiences influence neurobiological systems within genetic limits, leading to the neurobiological and behavioral manifestations of depression. We summarize the burgeoning evidence concerning a pre-eminent role of early adverse experience in the pathogenesis of depression. The available data suggest that (1) early adverse experience contributes to the pathophysiology of depression, (2) there are neurobiologically different subtypes of depression depending on the presence or absence of early adverse experience, likely having confounded previous research on the neurobiology of depression, and (3) early adverse experience likely influences treatment response in depression. Classification of depression based on developmental and neurobiological features will likely considerably improve future research in the field of depression, and might lead to optimized treatment strategies that directly target different neurobiological pathways to depression.

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Section: Neurobiology Of Elssupporting

confidence: 62%

Importance of Studying the Contributions of Early Adverse Experience to Neurobiological Findings in Depression

Heim

Plotsky

Nemeroff

2004

Neuropsychopharmacol

471

339

View full text Add to dashboard Cite

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“…Our findings of greater activation in these prefrontal areas are consistent with the findings of Bremner et al (1999aBremner et al ( , 1999b, who also found greater increase in superior and middle frontal gyrus (areas 6 and 9) in PTSD patients. Interestingly, a recent FDG-PET study found activation of right dorsolateral prefrontal cortex in rhesus monkeys after separation from their mothers compared with imaging performed after a period with their mothers (Rilling et al 2001). Thus, the stress of maternal separation seems to activate the same brain region as do memories of childhood abandonment in our patient group.…”

Section: Discussionmentioning

confidence: 45%

Neural correlates of memories of abandonment in women with and without borderline personality disorder

Schmahl

Elzinga

Vermetten

et al. 2003

Biological Psychiatry

143

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“…That is, although mPFC does not appear to spontaneously regulate amygdala reactivity early in life, it may do so during conditions of parental presence. Indeed, maternal presence has been shown to increase mPFC activity during a stressful procedure in juvenile macaques (Rilling et al, 2001), and lesions of the mPFC impair the dampening of physiological reactivity in this species (Herman et al, 2005). In addition, mPFC activity was shown to be higher in parental presence than under conditions of parental absence in the developing rodent Octodon degu (Bock et al, 2012).…”

Section: Phasic Parental Modulation Of Amygdala-prefrontal Circuitsmentioning

confidence: 99%

The Neuro-Environmental Loop of Plasticity: A Cross-Species Analysis of Parental Effects on Emotion Circuitry Development Following Typical and Adverse Caregiving

Callaghan

Tottenham

2015

Neuropsychopharmacol

227

210

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Early experiences critically shape the structure and function of the brain. Perturbations in typical/species-expected early experiences are known to have profound neural effects, especially in regions important for emotional responding. Parental care is one species-expected stimulus that plays a fundamental role in the development of emotion neurocircuitry. Emerging evidence across species suggests that phasic variation in parental presence during the sensitive period of childhood affects the recruitment of emotional networks on a moment-to-moment basis. In addition, it appears that increasing independence from caregivers cues the termination of the sensitive period for environmental input into emotion network development. In this review, we examine how early parental care, the central nervous system, and behavior come together to form a 'neuroenvironmental loop,' contributing to the formation of stable emotion regulation circuits. To achieve this end, we focus on the interaction of parental care and the developing amygdala-medial prefrontal cortex (mPFC) network-that is at the core of human emotional functioning. Using this model, we discuss how individual or group variations in parental independence, across chronic and brief timescales, might contribute to neural and emotional phenotypes that have implications for long-term mental health.

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Neural correlates of maternal separation in rhesus monkeys

Cited by 101 publications

References 38 publications

Importance of Studying the Contributions of Early Adverse Experience to Neurobiological Findings in Depression

Importance of Studying the Contributions of Early Adverse Experience to Neurobiological Findings in Depression

Neural correlates of memories of abandonment in women with and without borderline personality disorder

The Neuro-Environmental Loop of Plasticity: A Cross-Species Analysis of Parental Effects on Emotion Circuitry Development Following Typical and Adverse Caregiving

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