Neural correlates of malingering in mild traumatic brain injury: A positron emission tomography study

Spadoni, Andrea D.; Kosheleva, Elena; Buchsbaum, Monte S.; Simmons, Alan N.

doi:10.1016/j.pscychresns.2015.06.007

Cited by 10 publications

(6 citation statements)

References 46 publications

(50 reference statements)

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“…Consistent with the dysfunctional feedback loop hypothesis, Van Der Horn et al (2015) suggested that, because mPFC is involved prominently in emotional regulation, default mode network (DMN) hyperactivity and associated mPFC dysfunction are very likely linked to PCS persistence after mTBI. Supporting this notion, the positron emission tomography (PET) study of Spadoni et al (2015) found that chronic mTBI participants who had invested relatively little effort into their psychometric assessment tasks exhibited significantly lower glucose metabolism in ventromedial PFC compared to participants investing an adequate amount of effort. Furthermore, affective factors can be better PCS predictors than neuropsychological test measures; thus, such symptoms are likely more intimately linked to mTBI-related psychological disturbances rather than to genuine neurobiological changes, as detailed by Clarke et al (2012) .…”

Section: Depression Anxiety and Effortmentioning

confidence: 98%

Neuroimaging and Psychometric Assessment of Mild Cognitive Impairment After Traumatic Brain Injury

Calvillo

Irimia

2020

Front. Psychol.

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Traumatic brain injury (TBI) can be serious partly due to the challenges of assessing and treating its neurocognitive and affective sequelae. The effects of a single TBI may persist for years and can limit patients’ activities due to somatic complaints (headaches, vertigo, sleep disturbances, nausea, light or sound sensitivity), affective sequelae (post-traumatic depressive symptoms, anxiety, irritability, emotional instability) and mild cognitive impairment (MCI, including social cognition disturbances, attention deficits, information processing speed decreases, memory degradation and executive dysfunction). Despite a growing amount of research, study comparison and knowledge synthesis in this field are problematic due to TBI heterogeneity and factors like injury mechanism, age at or time since injury. The relative lack of standardization in neuropsychological assessment strategies for quantifying sequelae adds to these challenges, and the proper administration of neuropsychological testing relative to the relationship between TBI, MCI and neuroimaging has not been reviewed satisfactorily. Social cognition impairments after TBI (e.g., disturbed emotion recognition, theory of mind impairment, altered self-awareness) and their neuroimaging correlates have not been explored thoroughly. This review consolidates recent findings on the cognitive and affective consequences of TBI in relation to neuropsychological testing strategies, to neurobiological and neuroimaging correlates, and to patient age at and assessment time after injury. All cognitive domains recognized by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) are reviewed, including social cognition, complex attention, learning and memory, executive function, language and perceptual-motor function. Affect and effort are additionally discussed owing to their relationships to cognition and to their potentially confounding effects. Our findings highlight non-negligible cognitive and affective impairments following TBI, their gravity often increasing with injury severity. Future research should study (A) language, executive and perceptual-motor function (whose evolution post-TBI remains under-explored), (B) the effects of age at and time since injury, and (C) cognitive impairment severity as a function of injury severity. Such efforts should aim to develop and standardize batteries for cognitive subdomains—rather than only domains—with high ecological validity. Additionally, they should utilize multivariate techniques like factor analysis and related methods to clarify which cognitive subdomains or components are indeed measured by standardized tests.

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Section: Depression Anxiety and Effortmentioning

confidence: 98%

Neuroimaging and Psychometric Assessment of Mild Cognitive Impairment After Traumatic Brain Injury

Calvillo

Irimia

2020

Front. Psychol.

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“…Identifying the cause of this high prevalence of persistent post-concussive symptoms in the non-sports population has been a source of much speculation. Some of the most cited reasons for persistent complaints after concussion include: Persistent central nervous system neuropathology ( Bigler et al, 2016 ; D’Souza M et al, 2015 ; Dean, Sato, Vieira, McNamara, & Sterr, 2015 ; Nordin et al, 2016 ; Shahim et al, 2017 ; Zagorchev et al, 2016 ) Malingering ( Carroll et al, 2004 ; Cottingham & Boone, 2014 ; Lange, Iverson, Brooks, & Rennison, 2010 ; Spadoni, Kosheleva, Buchsbaum, & Simmons, 2015 ) Expectation effects ( Ferguson, Mittenberg, Barone, & Schneider, 1999 ; Waldron-Perrine, Tree, Spencer, Suhr, & Bieliauskas, 2015 ) Psychological conditions either preceding or subsequent to the injury ( Donnell, Kim, Silva, & Vanderploeg, 2012 ; Losoi et al, 2016 ; Macleod, 2010 ) Posttraumatic anxiety responses ( Bryant, 2011 ; Schneiderman, Braver, & Kang, 2008 ; Vasterling et al, 2012 ) Pituitary Dysfunction ( Sundaram, Geer, & Greenwald, 2013 ; Tanriverdi et al, 2015 ; Tanriverdi, Unluhizarci, & Kelestimur, 2010 ) Vestibular or oculomotor dysfunction ( Heitger et al, 2009 ; Suh et al, 2006 ) Chronic pain and/or comorbid injuries to the cervical spine ( Morin, Langevin, & Fait, 2016 ; Richter, 1995 ; Smith-Seemiller, Fow, Kant, & Franzen, 2003 ; Weyer Jamora, Schroeder, & Ruff, 2013 ) …”

Section: Introductionmentioning

confidence: 99%

“…Malingering ( Carroll et al, 2004 ; Cottingham & Boone, 2014 ; Lange, Iverson, Brooks, & Rennison, 2010 ; Spadoni, Kosheleva, Buchsbaum, & Simmons, 2015 )…”

Section: Introductionmentioning

confidence: 99%

Concussion and the autonomic nervous system: An introduction to the field and the results of a systematic review

Pertab

Merkley

Cramond³

et al. 2018

NRE

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BACKGROUND:Recent evidence suggests that autonomic nervous dysfunction may be one of many potential factors contributing to persisting post-concussion symptoms.OBJECTIVE:This is the first systematic review to explore the impact of concussion on multiple aspects of autonomic nervous system functioning.METHODS:The methods employed are in compliance with the American Academy of Neurology (AAN) and PRISMA standards. Embase, MEDLINE, PsychINFO, and Science Citation Index literature searches were performed using relevant indexing terms for articles published prior to the end of December 2016. Data extraction was performed by two independent groups, including study quality indicators to determine potential risk for bias according to the 4-tiered classification scheme of the AAN.RESULTS:Thirty-six articles qualified for inclusion in the analysis. Only three studies (one Class II and two Class IV) did not identify anomalies in measures of ANS functioning in concussed populations.CONCLUSIONS:The evidence supports the conclusion that it is likely that concussion causes autonomic nervous system anomalies. An awareness of this relationship increases our understanding of the physical impact of concussion, partially explains the overlap of concussion symptoms with other medical conditions, presents opportunities for further research, and has the potential to powerfully inform treatment decisions.

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“…PET imaging has been used to assess early injury mechanisms (Bergsneider et al 2001;Coles et al 2004), recovery (Yamaki et al 2018), long-term neural consequence (Barrio et al 2015;Bodart et al 2017;Lupi et al 2011) and neural correlates of functional deficits (Buchsbaum et al 2015;García-Panach et al 2011;Komura et al 2019;Nakashima et al 2007;Spadoni et al 2015) or interventions (Östberg et al 2018;Scott et al 2018). PET is a valuable approach for methodological corroboration of structure and functional brain results and can elucidate TBI pathophysiology in a manner not possible with MRI or CT. For example, one current hypothesis regarding the role of increased connectivity following TBI (i.e., hyperconnectivity) is that while potentially "compensatory" for function, enhancement of functional connections has longer term metabolic costs resulting in pathological protein aggregation (Hillary and Grafman 2017).…”

Section: Standardization Of Image Analysis Protocols For Ams-tbimentioning

confidence: 99%

Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group

Olsen

Babikian

Bigler

et al. 2020

Brain Imaging and Behavior

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The global burden of mortality and morbidity caused by traumatic brain injury (TBI) is significant, and the heterogeneity of TBI patients and the relatively small sample sizes of most current neuroimaging studies is a major challenge for scientific advances and clinical translation. The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Adult moderate/severe TBI (AMS-TBI) working group aims to be a driving force for new discoveries in AMS-TBI by providing researchers worldwide with an effective framework and platform for large-scale cross-border collaboration and data sharing. Based on the principles of transparency, rigor, reproducibility and collaboration, we will facilitate the development and dissemination of multiscale and big data analysis pipelines for harmonized analyses in AMS-TBI using structural and functional neuroimaging in combination with non-imaging biomarkers, genetics, as well as clinical and behavioral measures. Ultimately, we will offer investigators an unprecedented opportunity to test important hypotheses about recovery and morbidity in AMS-TBI by taking advantage of our robust methods for large-scale neuroimaging data analysis. In this consensus statement we outline the working group's shortterm, intermediate, and long-term goals.

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Neural correlates of malingering in mild traumatic brain injury: A positron emission tomography study

Cited by 10 publications

References 46 publications

Neuroimaging and Psychometric Assessment of Mild Cognitive Impairment After Traumatic Brain Injury

Neuroimaging and Psychometric Assessment of Mild Cognitive Impairment After Traumatic Brain Injury

Concussion and the autonomic nervous system: An introduction to the field and the results of a systematic review

Toward a global and reproducible science for brain imaging in neurotrauma: the ENIGMA adult moderate/severe traumatic brain injury working group

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