Neural correlates of individual ratings of emotional salience: a trial-related fMRI study

Phan, K. Luan; Taylor, Stephan F.; Welsh, Robert C.; Ho, Shao Hsuan; Britton, Jennifer C.; Liberzon, Israel

doi:10.1016/j.neuroimage.2003.09.072

Cited by 372 publications

(278 citation statements)

References 104 publications

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“…However, in the anticipation-probe run, anticipation was substantially disrupted and lengthened by the affect probes. To avoid confounding activation due to incentive anticipation with activation due to responding to the affect probes (Phan et al, 2004), only the outcome-probe runs were included in the whole-brain and VOI results.…”

Section: Discussionmentioning

confidence: 99%

“…However, investigators who used continuous online ratings in an FMRI study to probe affect during film clips reported no effect of rating on either self-reported affect or brain areas associated with the affective response to films (Hutcherson et al, 2005; although the NAcc was not one of these). The areas they and others (e.g., Phan et al, 2004;Taylor et al, 2003) have found to be associated with rating emotion (anterior cingulate, insula, and parietal cortex) were not the direct focus of this study, but further investigation of how online probes affect reward-related paradigms is needed.…”

Section: Discussionmentioning

confidence: 99%

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Valence and salience contribute to nucleus accumbens activation

Cooper¹,

Knutson²

2008

NeuroImage

232

176

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Different accounts of nucleus accumbens (NAcc) function have emphasized its role in representing either valence or salience during incentive anticipation. In an event-related FMRI experiment, we independently manipulated valence and salience by cuing participants to anticipate certain and uncertain monetary gains and losses. NAcc activation correlated with both valence and salience. On trials with certain outcomes, NAcc activation increased for anticipated gains and decreased for anticipated losses. On trials with uncertain outcomes, NAcc activation increased for both anticipated gains and losses but did not differ between them. These findings suggest that NAcc activation separately represents both valence and salience, consistent with its hypothesized role in appetitive motivation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Valence and salience contribute to nucleus accumbens activation

Cooper¹,

Knutson²

2008

NeuroImage

232

176

View full text Add to dashboard Cite

show abstract

“…In line with this hypothesis, there is evidence that activity in the MPFC increases linearly with increased ratings of self-relevance of stimuli. 75,77 A recent study by Moran et al 78 further suggests that the MPFC signals the personal relevance of incoming information even in the absence of explicit requirements for self-reflection (i.e., during passive viewing conditions).…”

Section: A Potential Role Of the Mpfc In Self-referential Processingmentioning

confidence: 99%

The Neural Basis of Semantic and Episodic Forms of Self-Knowledge: Insights from Functional Neuroimaging

D’Argembeau

Salmon

2012

Advances in Experimental Medicine and Biology

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Abstract:Throughout evolution, hominids have developed greater capacity to think about themselves in abstract and symbolic ways. This process has reached its apex in humans with the construction of a concept of self as a distinct entity with a personal history. This chapter provides a review of recent functional neuroimaging studies that have investigated the neural correlates of such "higher-level" aspects of the human self, focusing in particular on processes that allow individuals to consciously represent and reflect on their own personal attributes (semantic forms of self-knowledge) and experiences (episodic forms of self-knowledge). These studies point to the medial prefrontal cortex (MPFC) as a key neural structure for processing various kinds of self-referential information. We speculate that the MPFC may mediate dynamic processes that appraise and code the self-relatedness or self-relevance of information. This brain region may thus play a key role in creating the mental model of the self that is displayed in our mind at a given moment.Sensing in Nature, edited by Carlos López-Larrea.

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“…Of note, these latter studies all required veridical cognitively-based appraisals of affectively laden stimuli (similar to the AVA condition of this paradigm), yet these occurred in the absence of an explicitly self-relevant context, and therefore did not evoke cortical midline structures. Phan (2004) addressed the question of potentially dissociable neural substrates underlying appraisal of emotion and personal relatedness, comparing separate ratings of these criteria to activation evoked during presentation of affective pictorial stimuli. That study identified differential but overlapping neural substrates associated with ratings along either dimension, specifically ventral MPFC activation (as well as dorsal MPFC and anterior insula) was associated with appraisal of personal relatedness, the Amg with emotional intensity, and the Nacc with both appraisal types.…”

Section: Ventral Ampfc Networkmentioning

confidence: 99%

Self-appraisal decisions evoke dissociated dorsal—ventral aMPFC networks

2006

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The anterior medial prefrontal cortex (aMPFC) is consistently active during personally salient decisions, yet the differential contributory processes of this region along the dorsal-ventral axis are less understood. Using a self-appraisal decision-making task and functional magnetic resonance imaging, we demonstrated task-dependent connectivity of ventral aMPFC with amygdala, insula, and nucleus accumbens, and dorsal aMPFC connectivity with dorsolateral PFC and bilateral hippocampus. These aMPFC networks appear to subserve distinct contributory processes inherent to self-appraisal decisions, specifically a dorsally mediated cognitive and a ventrally mediated affective/self-relevance network.

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Neural correlates of individual ratings of emotional salience: a trial-related fMRI study

Cited by 372 publications

References 104 publications

Valence and salience contribute to nucleus accumbens activation

Valence and salience contribute to nucleus accumbens activation

The Neural Basis of Semantic and Episodic Forms of Self-Knowledge: Insights from Functional Neuroimaging

Self-appraisal decisions evoke dissociated dorsal—ventral aMPFC networks

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