Neural correlates of improved recognition of happy faces after erythropoietin treatment in bipolar disorder

Miskowiak, Kamilla Woznica; Petersen, Nanna Aagaard; Harmer, Catherine J.; Ehrenreich, E.; Kessing, Lars Vedel; Vinberg, Maj; Macoveanu, Julian; Siebner, Hartwig R.

doi:10.1111/acps.12915

Cited by 5 publications

(3 citation statements)

References 47 publications

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“…In addition, as left and right PFCs are known to differentially modulate the down-stream limbic areas ( Cerqueira et al, 2008 ), EPO-induced enhancement of synaptic inhibition in the left PrL would down-regulated the down-stream HPA axis, and EPO-induced reduction of synaptic inhibition in the right PrL would then enhance the down-stream hippocampal activity and plasticity (illustrated in Graphic abstract). Thus, the lateralized EPO effect in the present study might contribute to the beneficial effects of EPO under stress as well as by mental disorders ( Czéh et al, 2018 ; Ehrenreich et al, 2008 , 2007b ; 2007a ; Miskowiak, 2017 ; Miskowiak et al, 2018 , 2010 ).…”

Section: Discussionmentioning

confidence: 69%

“…Similarly, an increase in cognitive performance upon EPO in patients with chronic progressive multiple sclerosis has been occurred independently of changes in hemoglobin levels, and persisted for months after termination of EPO treatment ( Ehrenreich et al, 2008 , 2007a ). Furthermore, EPO has also been shown to improve the cognitive ability in patients with mood disorder ( Miskowiak, 2017 ; Miskowiak et al, 2018 , 2010 ).…”

Section: Introductionmentioning

confidence: 99%

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Contradictory effects of erythropoietin on inhibitory synaptic transmission in left and right prelimbic cortex of mice

Dik

Saffari

Zhang

et al. 2018

Neurobiology of Stress

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Erythropoietin (EPO) has been shown to improve cognitive function in mammals as well as in patients of psychiatric diseases by directly acting on the brain. In addition, EPO attenuates the synaptic transmission and enhances short- and long-term synaptic plasticity in hippocampus of mice, although there are still many discrepancies between different studies. It has been suggested that the divergences of different studies take root in different in-vivo application schemata or in long-term trophic effects of EPO. In the current study, we investigated the direct effects of EPO in slices of prelimbic cortex (PrL) by acute ex-vivo application of EPO, so that the erythropoietic or other trophic effects could be entirely excluded. Our results showed that the EPO effects were contradictory between the left and the right PrL. It enhanced the inhibitory transmission in the left and depressed the inhibitory transmission in the right PrL. Strikingly, this lateralized effect of EPO could be consistently found in individual bi-lateral PrL of all tested mice. Thus, our data suggest that EPO differentially modulates the inhibitory synaptic transmission of neuronal networks in the left and the right PrL. We hypothesize that such lateralized effects of EPO contribute to the development of the lateralization of stress reaction in PFC and underlie the altered bilateral GAGAergic synaptic transmission and oscillation patterns under stress that impact the central emotional and cognitive control in physiology as well as in pathophysiology.

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Section: Discussionmentioning

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Contradictory effects of erythropoietin on inhibitory synaptic transmission in left and right prelimbic cortex of mice

Dik

Saffari

Zhang

et al. 2018

Neurobiology of Stress

View full text Add to dashboard Cite

show abstract

“…Bipolar disorder (BD) is an emotional disorder characterized by emotional instability [1,2], the main symptoms of which are emotional processing disorders [3,4]. While previous studies have found that patients with BD have mood-recognition disorder during remission, which appears as defective emotion recognition, other reports suggest that patients may have complete emotional perception [5].…”

Section: Introductionmentioning

confidence: 99%

Late Positive Potential in Bipolar Disorder Reflecting Emotional Disorder: An Event-Related Potential Study

Zhou¹,

Zhang²,

Liang³

et al. 2019

J Dep Anxiety

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Introduction: Bipolar disorder (BD) is an emotional disorder characterized by emotional instability. This study aims to investigate whether emotional disorders affect the cortical processing that regulates emotional stimuli. Methods: This study uses a passive viewing paradigm to compare event-related potentials (ERPs) of 21 subjects with bipolar disorder (BD), 25 subjects with schizophrenia (SZ), and 25 normal subjects (HC). Results: In the frontal and parietal areas (1) the late positive potential (LPP) amplitude of BD was greater than that of SZ and HC, and there was no difference in terms of peak latency. (2) In the occipital area, the amplitude and latency of P300 of SZ and BD were significantly larger than HC, but there was no difference between SZ and BD. (3) The behavioral results demonstrated that BDs' valence rating on both positive and negative stimuli were significantly higher than those of HC and SZ when viewing face images, while BDs' arousal scores for positive stimuli were significantly lower than HC and SZ. BDs' arousal score for negative stimuli was significantly higher than those of HC and SZ. When viewing non-face pictures, BDs' positive valence rating on negative stimuli and arousal scores for positive stimuli were significantly higher than those of HC and SZ. Conclusion: Bipolar patients have complete early emotional recognition, and their emotional abnormalities exist in the late evaluation of emotional stimuli, mainly occurring in the frontal and parietal areas.

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The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder

Rotenberg

Kjærstad

Varo

et al. 2023

European Neuropsychopharmacology

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Neural correlates of improved recognition of happy faces after erythropoietin treatment in bipolar disorder

Abstract: Together with previous findings, the present observation suggests that increased dorsal prefrontal attention control is a common mechanism of EPO-associated improvements across several cognitive domains.

Cited by 5 publications

References 47 publications

Contradictory effects of erythropoietin on inhibitory synaptic transmission in left and right prelimbic cortex of mice

Contradictory effects of erythropoietin on inhibitory synaptic transmission in left and right prelimbic cortex of mice

Late Positive Potential in Bipolar Disorder Reflecting Emotional Disorder: An Event-Related Potential Study

The longitudinal trajectory of emotional cognition in subgroups of recently diagnosed patients with bipolar disorder

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