Neural correlates of human somatosensory integration in tinnitus

Lanting, Cornelis P.; Kleine, Emile de; Eppinga, Ruben N.; Dijk, Pim van

doi:10.1016/j.heares.2010.04.006

Cited by 56 publications

(47 citation statements)

References 60 publications

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“…Electrical stimulation of the trigeminal ganglion has been reported to evoke mixed, but predominantly excitatory, neuronal responses in the dorsal and ventral cochlear nuclei [Shore et al, 2003;Shore, 2005;Shore et al, 2007;Dehmel et al, 2008]. A recent imaging study observed that jaw protrusion increased activity in the auditory pathway in patients with tinnitus and normal controls [Lanting et al, 2010]. Moreover, compared with control subjects, the patients showed an enhanced response to jaw protrusion at the level of the cochlear nucleus and inferior colliculus, the auditory centers in the midbrain and the brainstem.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Factors Associated with Neck and Jaw Muscle Modulation of Tinnitus

Won¹,

Yoo²,

Lee³

et al. 2013

Audiol Neurotol

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Forceful contractions of neck and jaw muscles have consistently been shown to modulate tinnitus and can be used to screen patients who are responsive to somatic stimulation and, therefore, optimal candidates for somatosensory-based treatment. To identify the factors associated with somatic modulation of tinnitus, 163 patients underwent 19 neck and jaw maneuvers after an extensive physiological and audiological profile was compiled. Overall, tinnitus was modulated in 57.1% of ears tested. Unilateral tinnitus showed greater prevalence of modulation. Neck maneuvers generally decreased tinnitus loudness, whereas jaw maneuvers increased loudness. Female gender and buzzing tinnitus were associated with a high prevalence of modulation and a decrease in tinnitus loudness. Loud tinnitus and low-pitched tonal tinnitus were associated with exacerbation of the condition as a result of somatic testing. Use of these characteristics to select optimal candidates for somatosensory-based tinnitus therapies may be essential for the development of an effective approach for tinnitus treatment.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Factors Associated with Neck and Jaw Muscle Modulation of Tinnitus

Won¹,

Yoo²,

Lee³

et al. 2013

Audiol Neurotol

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“…In particular, convergent evidence from animal models and human studies indicated a relationship between abnormal tinnitus-related activity in the auditory system and the cerebellum as a potential source of aberrant input (Brozoski et al, 2007;Lanting et al, 2009Lanting et al, , 2010Morest et al, 1997;Shulman and Strashun, 1999;Shulman and Goldstein, 2010;Shulman et al, 2009). Similarly, the auditory deficits we reported in patients with cerebellar degenerative conditions (Parsons et al, 2009) suggest that it will also be important to determine if age-related degeneration of the cerebellum may contribute to auditory disfunctions.…”

Section: Discussionmentioning

confidence: 99%

Increased activation of the human cerebellum during pitch discrimination: A positron emission tomography (PET) study

et al. 2011

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“…Early positron emission tomography (PET) studies have demonstrated tinnitus-related activity in primary and secondary auditory cortex [40-42] as well as auditory association cortex [41,43-47]. Correspondingly, numerous functional magnetic resonance imaging (fMRI) studies of tinnitus have revealed increases of sound-evoked activity for cortical [14,48,49] and subcortical stations along the auditory pathway [50-52]. Besides mere changes of activity levels within the auditory system, studies using magnetoelectroencephalography (MEG) report abnormal activity in different frequency bands [53], which has been embedded in the concept of abnormal thalamocortical oscillations as a mechanism underlying tinnitus and chronic pain [54].…”

Section: Brain Structure and Function In Tinnitus And Chronic Painmentioning

confidence: 99%

Frontostriatal Gating of Tinnitus and Chronic Pain

Rauschecker

Maudoux

et al. 2015

Trends in Cognitive Sciences

193

168

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Tinnitus and chronic pain are sensory-perceptual disorders associated with negative affect and high impact on well-being and behavior. It is now becoming increasingly clear that higher cognitive and affective brain systems are critically involved in the pathology of both disorders. Here, we propose that the ventromedial prefrontal cortex and the nucleus accumbens are part of a central “gatekeeping” system in both sensory modalities, which evaluates the relevance and affective value of sensory stimuli and controls information flow via descending pathways. If this frontostriatal system is compromised, long-lasting disturbances are the result. Parallels in both systems are striking and mutually informative, and progress in understanding central gating mechanisms might provide a new impetus to the therapy of tinnitus and chronic pain.

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Neural correlates of human somatosensory integration in tinnitus

Cited by 56 publications

References 60 publications

Prevalence and Factors Associated with Neck and Jaw Muscle Modulation of Tinnitus

Prevalence and Factors Associated with Neck and Jaw Muscle Modulation of Tinnitus

Increased activation of the human cerebellum during pitch discrimination: A positron emission tomography (PET) study

Frontostriatal Gating of Tinnitus and Chronic Pain

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