Neural correlates of heart-focused interoception: a functional magnetic resonance imaging meta-analysis

Schulz, Stefan M.

doi:10.1098/rstb.2016.0018

Cited by 168 publications

(147 citation statements)

References 98 publications

(239 reference statements)

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“…Indeed, frontal regions, such as the orbitofrontal cortex, the inferior frontal gyrus, the insula, and the anterior cingulate cortex, have been widely associated with interoception (Craig, 2002, 2009; Critchley et al, 2004; Becker et al, 2015; Hassanpour et al, 2016; Kuehn et al, 2016; Pollatos et al, 2016; Schulz, 2016; Strigo and Craig, 2016). Moreover, some studies suggest that body signal processing is considerably right-lateralized (Naver et al, 1996; Leopold and Schandry, 2001; Meyer et al, 2004; Couto et al, 2015a).…”

Section: Methodsmentioning

confidence: 99%

Attention, in and Out: Scalp-Level and Intracranial EEG Correlates of Interoception and Exteroception

et al. 2017

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Interoception, the monitoring of visceral signals, is often presumed to engage attentional mechanisms specifically devoted to inner bodily sensing. In fact, most standardized interoceptive tasks require directing attention to internal signals. However, most studies in the field have failed to compare attentional modulations between internally- and externally-driven processes, thus probing blind to the specificity of the former. Here we address this issue through a multidimensional approach combining behavioral measures, analyses of event-related potentials and functional connectivity via high-density electroencephalography, and intracranial recordings. In Study 1, 50 healthy volunteers performed a heartbeat detection task as we recorded modulations of the heartbeat-evoked potential (HEP) in three conditions: exteroception, basal interoception (also termed interoceptive accuracy), and post-feedback interoception (sometimes called interoceptive learning). In Study 2, to evaluate whether key interoceptive areas (posterior insula, inferior frontal gyrus, amygdala, and somatosensory cortex) were differentially modulated by externally- and internally-driven processes, we analyzed human intracranial recordings with depth electrodes in these regions. This unique technique provides a very fine grained spatio-temporal resolution compared to other techniques, such as EEG or fMRI. We found that both interoceptive conditions in Study 1 yielded greater HEP amplitudes than the exteroceptive one. In addition, connectivity analysis showed that post-feedback interoception, relative to basal interoception, involved enhanced long-distance connections linking frontal and posterior regions. Moreover, results from Study 2 showed a differentiation between oscillations during basal interoception (broadband: 35–110 Hz) and exteroception (1–35 Hz) in the insula, the amygdala, the somatosensory cortex, and the inferior frontal gyrus. In sum, this work provides convergent evidence for the specificity and dynamics of attentional mechanisms involved in interoception.

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Section: Methodsmentioning

confidence: 99%

Attention, in and Out: Scalp-Level and Intracranial EEG Correlates of Interoception and Exteroception

et al. 2017

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“…This transformation was then applied to all the individual GM segmented scans to also be brought into standard space. We also included the bilateral superior occipital cortex as a control region to test the specificity of our results regarding the interoceptive network-this area was selected based on previous reports showing its lack of association with interoception (Adolfi et al, 2017;Farb, Segal, & Anderson, 2013;Schulz, 2016). Finally, an isotropic Gaussian kernel of 12-mm full width at half maximum was applied to all images.…”

Section: Image Acquisition and Analysismentioning

confidence: 99%

Altered neural signatures of interoception in multiple sclerosis

Salamone

Esteves

Sinay

et al. 2018

Human Brain Mapping

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Multiple sclerosis (MS) patients present several alterations related to sensing of bodily signals. However, no specific neurocognitive impairment has yet been proposed as a core deficit underlying such symptoms. We aimed to determine whether MS patients present changes in interoception-that is, the monitoring of autonomic bodily information-a process that might be related to various bodily dysfunctions. We performed two studies in 34 relapsing-remitting, early-stage MS patients and 46 controls matched for gender, age, and education. In Study 1, we evaluated the heartbeat-evoked potential (HEP), a cortical signature of interoception, via a 128-channel EEG system during a heartbeat detection task including an exteroceptive and an interoceptive condition. Then, we obtained whole-brain MRI recordings. In Study 2, participants underwent fMRI recordings during two resting-state conditions: mind wandering and interoception. In Study 1, controls exhibited greater HEP modulation during the interoceptive condition than the exteroceptive one, but no systematic differences between conditions emerged in MS patients. Patients presented atrophy in the left insula, the posterior part of the right insula, and the right anterior cingulate cortex, with abnormal associations between neurophysiological and neuroanatomical patterns. In Study 2, controls showed higher functional connectivity and degree for the interoceptive state compared with mind wandering; however, this pattern was absent in patients, who nonetheless presented greater connectivity and degree than controls during mind wandering. MS patients were characterized by atypical multimodal brain signatures of interoception. This finding opens a new agenda to examine the role of inner-signal monitoring in the body symptomatology of MS.

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“…Schulz [43] presents a meta-analysis of functional neuroimaging (fMRI) studies of interoceptive attentiveness (i.e. focused attention to a particular interoceptive signal for a given time interval) to one's heartbeat.…”

Section: Measuring and Modulating Interoceptionmentioning

confidence: 99%

Interoception beyond homeostasis: affect, cognition and mental health

Tsakiris

Critchley

2016

Phil. Trans. R. Soc. B

200

142

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Interoception refers to the sensing of the internal state of one's body. Interoception is distinct from the processing of sensory information concerning external (non-self) stimuli (e.g. vision, hearing, touch and smell) and is the afferent axis to internal (autonomic and hormonal) physiological control. However, the impact of interoception extends beyond homeostatic/allostatic reflexes: it is proposed to be fundamental to motivation, emotion (affective feelings and behaviours), social cognition and self-awareness. This view is supported by a growing body of experimental evidence that links peripheral physiological states to mental processes. Within this framework, the representation of self is constructed from early development through continuous integrative representation of biological data from the body, to form the basis for those aspects of conscious awareness grounded on the subjective sense of being a unique individual. This theme issue of the Philosophical Transactions of the Royal Society B draws together state-of-the-art knowledge concerning theoretical, experimental and clinical facets of interoception with the emphasis on cognitive and affective neuroscience. The multidisciplinary and cross-disciplinary perspectives represented in this theme issue disseminate and entrench knowledge about interoception across the scientific community and provide a reference for the conceptualization and further study of interoception across behavioural sciences.

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Neural correlates of heart-focused interoception: a functional magnetic resonance imaging meta-analysis

Cited by 168 publications

References 98 publications

Attention, in and Out: Scalp-Level and Intracranial EEG Correlates of Interoception and Exteroception

Attention, in and Out: Scalp-Level and Intracranial EEG Correlates of Interoception and Exteroception

Altered neural signatures of interoception in multiple sclerosis

Interoception beyond homeostasis: affect, cognition and mental health

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