Neural correlates of emotion recognition in schizophrenia

Habel, Ute; Chechko, Natalia; Pauly, Katharina; Koch, Kathrin; Backes, Volker; Seiferth, Nina; Shah, N. Jon; Stöcker, Tony; Schneider, Frank; Kellermann, Thilo

doi:10.1016/j.schres.2010.06.009

Cited by 115 publications

(97 citation statements)

References 42 publications

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“…In two studies, this was corroborated behaviourally, with patients more likely to misidentify neutral faces as fearful or other negative emotions [61,62]. Despite few studies available for review, the overall finding in patients was increased activity in regions central to both the 'ventral' and 'dorsal' emotional processing streams, including the amygdala, hippocampus, AC, PFC and parahippocampal gyrus.…”

Section: Evidence For An Interpretative Bias Towards Threat In Psychosismentioning

confidence: 90%

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Psychobiology of threat appraisal in the context of psychotic experiences: A selective review

2015

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A key factor in the transition to psychosis is the appraisal of anomalous experiences as threatening.Cognitive models of psychosis have identified attentional and interpretative biases underlying threatbased appraisals. While much research has been conducted into these biases within the clinical and cognitive literature, little examination has occurred at the neural level. However, neurobiological research in social cognition employing threatening stimuli mirror cognitive accounts of maladaptive appraisal in psychosis. This review attempted to integrate neuroimaging data regarding social cognition in psychosis with the concepts of attentional and interpretative threat biases. Systematic review methodology was used to identify relevant articles from Medline, PsycINFO and EMBASE, and PubMed databases. The selective review showed that attentional and interpretative threat biases relate to abnormal activation of a range of subcortical and prefrontal structures, including the amygdala, insula, hippocampus, anterior cingulate, and prefrontal cortex, as well as disrupted connectivity between these regions, when processing threatening and neutral or ambiguous stimuli.Notably, neural findings regarding the misattribution of threat to neutral or ambiguous stimuli presented a more consistent picture. Overall, however, the findings for any specific emotion were mixed, both in terms of the specific brain areas involved and the direction of effects (increased/decreased activity), possibly owing to confounds including small sample sizes, varying experimental paradigms, medication, and heterogeneous, in some cases poorly characterised, patient groups. Further neuroimaging research examining these biases by employing experimentally-induced anomalous perceptual experiences and well-characterised large samples is needed for greater aetiological specificity.

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Section: Evidence For An Interpretative Bias Towards Threat In Psychosismentioning

confidence: 90%

“…Of those that did, impairment in patients related solely to fearful/angry faces [58,61], apart from one study discussed above [62].…”

Section: Misattribution Of Threat To Neutral or Positive Stimulimentioning

confidence: 96%

Psychobiology of threat appraisal in the context of psychotic experiences: A selective review

2015

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“…39 Hence, new signal processing methods like single-trial classification and modeling of event-related brain dynamics using time-frequency or blind source separation analysis may be favorable for modeling complex pathophysiological network processes. [39][40][41] Next, new paradigms or the investigation of other cognitive domains, eg, theory of mind 42 or emotion recognition, 43 could prove highly beneficial for discriminating schizophrenia and control groups. Last, magnetic resonance imaging methods have shown to hold some promise for differentiating between schizophrenia and mentally healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

Critical Evaluation of Auditory Event-Related Potential Deficits in Schizophrenia: Evidence From Large-Scale Single-Subject Pattern Classification

Neuhaus

Popescu

Rentzsch

et al. 2013

Schizophrenia Bulletin

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Event-related potential (ERP) deficits associated with auditory oddball and click-conditioning paradigms are among the most consistent findings in schizophrenia and are discussed as potential biomarkers. However, it is unclear to what extend these ERP deficits distinguish between schizophrenia patients and healthy controls on a single-subject level, which is of high importance for potential translation to clinical routine. Here, we investigated 144 schizophrenia patients and 144 matched controls with an auditory click-conditioning/oddball paradigm. P50 and N1 gating ratios as well as target-locked N1 and P3 components were submitted to conventional general linear models and to explorative machine learning algorithms. Repeatedmeasures ANOVAs revealed significant between-group differences for the oddball-locked N1 and P3 components but not for any gating measure. Machine learning-assisted analysis achieved 77.7% balanced classification accuracy using a combination of target-locked N1 and P3 amplitudes as classifiers. The superiority of machine learning over repeated-measures analysis for classifying schizophrenia patients was in the range of about 10% as quantified by receiver operating characteristics. For the first time, our study provides large-scale single-subject classification data on auditory click-conditioning and oddball paradigms in schizophrenia. Although our study exemplifies how automated inference may substantially improve classification accuracy, our data also show that the investigated ERP measures show comparably poor discriminatory properties in single subjects, thus illustrating the need to establish either new analytical approaches for these paradigms or other paradigms to investigate the disorder.

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“…Habel et al [62] reported hyperactivation of the right precentral gyrus, extending to the right inferior frontal gyrus. A meta-analysis revealed that, during facial emotion perception, a larger signal was found in the cuneus, left parietal lobule, right precentral gyrus, and left temporal lobe; areas which are not commonly activated in emotional tasks (with the exception of the left temporal lobe) [53].…”

Section: Neural Correlates Of Facial Emotion Processingmentioning

confidence: 98%

Facial emotion processing in schizophrenia: a review of behavioural and neural correlates

Grave¹,

Soares²,

Martins³

et al. 2017

IJCNMH

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Schizophrenia is one of the most severe psychiatric conditions, often associated with deficits in social cognition. Social cognition deficits are predictors of functionality in patients and involve theory of mind, attributional style, social perception, and emotional processing. In particular, facial emotion processing (an important domain of emotional processing) seems to be particularly related to cognitive and social functioning, and to positive and negative symptoms. Patients with schizophrenia have difficulties in processing emotional faces; however, those impairments are still far from fully understood. In this review, we addressed the behavioural and neural correlates of facial emotion processing in schizophrenia. Despite studies showing impairments in both positive and negative faces, the most consistent findings involved negative faces. Moreover, patients with schizophrenia showed abnormalities in the social brain neural circuit during facial emotion processing. While some studies described hypoactivation of brain areas related to emotional processing, such as the amygdala, others reported hyperactivation, leading to a high number of inconsistencies. The findings are limited by the experimental designs used, and the clinical and demographic characteristics of patients. Despite such variable findings, there has been growing interest in developing psychosocial interventions focused directly on social cognitive impairments in schizophrenia, with potential impact on patient's ability to perceive emotional faces. We provide a critical perspective on current evidence and suggest new pathways of research. The understanding of the mechanisms underlying facial emotion processing in schizophrenia could enhance functionality and quality of life by providing innovative approaches to the interpersonal difficulties patients frequently experience.

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Neural correlates of emotion recognition in schizophrenia

Cited by 115 publications

References 42 publications

Psychobiology of threat appraisal in the context of psychotic experiences: A selective review

Psychobiology of threat appraisal in the context of psychotic experiences: A selective review

Critical Evaluation of Auditory Event-Related Potential Deficits in Schizophrenia: Evidence From Large-Scale Single-Subject Pattern Classification

Facial emotion processing in schizophrenia: a review of behavioural and neural correlates

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