Neural correlates of dysfunctional emotion regulation in major depressive disorder. A systematic review of neuroimaging studies

Rive, Maria M.; Rooijen, Geeske van; Veltman, Dick J.; Phillips, Mary L.; Schene, Aart H.; Ruhé, Henricus G.

doi:10.1016/j.neubiorev.2013.07.018

Cited by 392 publications

(345 citation statements)

References 127 publications

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“…This finding again is well in line with those of a variety of functional imaging studies in MDD reporting overactive signalling during emotion processing in a medial network involving the OFC, the amygdala and the insula as key structures of dysfunctional emotion processing in depressed patients. 5,39,40 Interestingly no association between familial risk for MDD and altered neural signalling in the medial OFC could be detected. These findings add to the specificity of overreactive medial OFC response as a state marker of acute MDD, which is underlined by the observed positive association between depressive symptoms and OFC response to negative faces.…”

Section: Discussionmentioning

confidence: 93%

Prefrontal brain responsiveness to negative stimuli

Redlich

Grotegerd

Dohm

et al. 2017

JPN

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Section: Discussionmentioning

confidence: 93%

Prefrontal brain responsiveness to negative stimuli

Redlich

Grotegerd

Dohm

et al. 2017

JPN

View full text Add to dashboard Cite

“…Brain networks A vast body of evidence shows alterations in brain networks in patients with psychiatric disorders (Broyd et al 2009;Rive et al 2013;Kaiser et al 2015). The relations of fatty acid metabolism with brain structure and BDNF described above in Neuronal membrane structure and Other mechanisms are reflected in emerging evidence associating fatty acids with brain network structure and function (McNamara 2013;Bos et al 2016).…”

Section: Associations With Other Pathophysiological Mechanismsmentioning

confidence: 99%

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Mocking

Assies

Ruhé

et al. 2018

J of Inher Metab Disea

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Continuous research into the pathophysiology of psychiatric disorders, such as major depressive disorder (MDD), posttraumatic stress disorder (PTSD), and schizophrenia, suggests an important role for metabolism. This narrative review will provide an upto-date summary of how metabolism is thought to be involved in the pathophysiology of these psychiatric disorders. We will focus on (I) the important role of fatty acids in these metabolic alterations, (II) whether fatty acid alterations represent epiphenomena or risk factors, and (III) similarities and dissociations in fatty acid alterations between different psychiatric disorders. (Historical) epidemiological evidence links fatty acid intake to psychiatric disorder prevalence, corroborated by altered fatty acid concentrations measured in psychiatric patients. These fatty acid alterations are connected with other concomitant pathophysiological mechanisms, including biological stress (hypothalamic-pituitary-adrenal (HPA)-axis and oxidative stress), inflammation, and brain network structure and function. Metabolomics and lipidomics studies are underway to more deeply investigate this complex network of associated neurometabolic alterations. Supplementation of fatty acids as disease-modifying nutraceuticals has clinical potential, particularly add-on eicosapentaenoic acid (EPA) in depressed patients with markers of increased inflammation. However, by interpreting the observed fatty acid alterations as partly (mal)adaptive phenomena, we attempt to nuance translational expectations and provide new clinical applications for these novel neurometabolic insights, e.g., to predict treatment response or depression recurrence. In conclusion, placing fatty acids in context can contribute to further understanding and optimized treatment of psychiatric disorders, in order to diminish their overwhelming burden of disease.

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“…Given the abundant literature implicating NE signaling in prefrontal cortical function (25,26), it is conceivable that stress-induced elevations in prefrontal NE release (27)(28)(29) contribute to extinction impairments associated with PTSD. The medial prefrontal cortex (mPFC), comprising the prelimbic (PL) and infralimbic (IL) subdivisions in rodents, plays a key role in the regulation of emotional behavior in both humans and rats (30,31). Previous studies have suggested that PL plays an important role in fear expression, whereas IL is preferentially involved in fear extinction (32)(33)(34).…”

mentioning

confidence: 99%

Noradrenergic blockade stabilizes prefrontal activity and enables fear extinction under stress

Fitzgerald

Giustino

Seemann

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

117

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Stress-induced impairments in extinction learning are believed to sustain posttraumatic stress disorder (PTSD). Noradrenergic signaling may contribute to extinction impairments by modulating medial prefrontal cortex (mPFC) circuits involved in fear regulation. Here we demonstrate that aversive fear conditioning rapidly and persistently alters spontaneous single-unit activity in the prelimbic and infralimbic subdivisions of the mPFC in behaving rats. These conditioning-induced changes in mPFC firing were mitigated by systemic administration of propranolol (10 mg/kg, i.p.), a β-noradrenergic receptor antagonist. Moreover, propranolol administration dampened the stress-induced impairment in extinction observed when extinction training is delivered shortly after fear conditioning. These findings suggest that β-adrenoceptors mediate stress-induced changes in mPFC spike firing that contribute to extinction impairments. Propranolol may be a helpful adjunct to behavioral therapy for PTSD, particularly in patients who have recently experienced trauma.fear | extinction | propranolol | prefrontal cortex | rat

show abstract

Neural correlates of dysfunctional emotion regulation in major depressive disorder. A systematic review of neuroimaging studies

Cited by 392 publications

References 127 publications

Prefrontal brain responsiveness to negative stimuli

Prefrontal brain responsiveness to negative stimuli

Focus on fatty acids in the neurometabolic pathophysiology of psychiatric disorders

Noradrenergic blockade stabilizes prefrontal activity and enables fear extinction under stress

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