Neural correlates of dual-task walking in people with central neurological disorders: a systematic review

Kim, Hyejun; Fraser, Sarah

doi:10.1007/s00415-021-10944-5

Cited by 11 publications

(7 citation statements)

References 98 publications

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“…Under all conditions, the low DTC group was younger, had faster usual gait speed, was less cognitively impaired, and had lower WMH burden corresponding ( Figure 1 ). Consistent with studies showing frontal brain areas are relevant for dual task walking performance ( Kim and Fraser, 2022 ), dual task gait costs were associated with increased global WMH volume and most consistently with greater frontal WMH volume in the simplest counting backward task. We conclude that DTC may differ based on the secondary task and that WMH are associated with DTC.…”

Section: Discussionsupporting

confidence: 84%

Dual-task gait and white matter hyperintensities in Lewy body diseases: An exploratory analysis

Fatokun

Gee

Nelles

et al. 2023

Front. Aging Neurosci.

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BackgroundParkinson’s disease (PD) and dementia with Lewy bodies (DLB) are part of a spectrum of Lewy body disorders, who exhibit a range of cognitive and gait impairments. Cognitive-motor interactions can be examined by performing a cognitive task while walking and quantified by a dual task cost (DTC). White matter hyperintensities (WMH) on magnetic resonance imaging have also been associated with both gait and cognition. Our goal was to examine the relationship between DTC and WMH in the Lewy body spectrum, hypothesizing DTC would be associated with increased WMH volume.MethodsSeventy-eight participants with PD, PD with mild cognitive impairment (PD-MCI), PD with dementia or DLB (PDD/DLB), and 20 cognitively unimpaired participants were examined in a multi-site study. Gait was measured on an electronic walkway during usual gait, counting backward, animal fluency, and subtracting sevens. WMH were quantified from magnetic resonance imaging using an automated pipeline and visual rating. A median split based on DTC was performed. Models included age as well as measures of global cognition and cardiovascular risk.ResultsCompared to cognitively unimpaired participants, usual gait speed was lower and DTC was higher in PD-MCI and PDD/DLB. Low DTC participants had higher usual gait speed. WMH burden was greater in high counting DTC participants. Frontal WMH burden remained significant after adjusting for age, cardiovascular risk and global cognition.ConclusionIncreased DTC was associated with higher frontal WMH burden in Lewy body disorders after adjusting for age, cardiovascular risk, and global cognition. Higher DTC was associated with age.

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Section: Discussionsupporting

confidence: 84%

Dual-task gait and white matter hyperintensities in Lewy body diseases: An exploratory analysis

Fatokun

Gee

Nelles

et al. 2023

Front. Aging Neurosci.

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“…Previous studies also reported higher cognitive DTC in PD (43,84) and stroke patients (4) compared with healthy participants. This has been linked to physical and cognitive impairment related to these disorders and to reduced attention and cognitive reserve (85). In MS patients, on the other hand, studies have shown a negative effect of DT on cognitive performance (6,86), but only a few studies have reported data on cognitive DTC and it remains unclear whether this differs between MS patients and healthy participants (3).…”

Section: E Ect Of Age and Disease Groupmentioning

confidence: 99%

Cognitive dual-task cost depends on the complexity of the cognitive task, but not on age and disease

Bianchini

Warmerdam²,

Romijnders³

et al. 2022

Front. Neurol.

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IntroductionDual-tasking (DT) while walking is common in daily life and can affect both gait and cognitive performance depending on age, attention prioritization, task complexity and medical condition. The aim of the present study was to investigate the effects of DT on cognitive DT cost (DTC) (i) in a dataset including participants of different age groups, with different neurological disorders and chronic low-back pain (cLBP) (ii) at different levels of cognitive task complexity, and (iii) in the context of a setting relevant to daily life, such as combined straight walking and turning.Materials and methodsNinety-one participants including healthy younger and older participants and patients with Parkinson's disease, Multiple Sclerosis, Stroke and cLBP performed a simple reaction time (SRT) task and three numerical Stroop tasks under the conditions congruent (StC), neutral (StN) and incongruent (StI). The tasks were performed both standing (single task, ST) and walking (DT), and DTC was calculated. Mixed ANOVAs were used to determine the effect of group and task complexity on cognitive DTC.ResultsA longer response time in DT than in ST was observed during SRT. However, the response time was shorter in DT during StI. DTC decreased with increasing complexity of the cognitive task. There was no significant effect of age and group on cognitive DTC.ConclusionOur results suggest that regardless of age and disease group, simple cognitive tasks show the largest and most stable cognitive effects during DT. This may be relevant to the design of future observational studies, clinical trials and for clinical routine.

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“…In recent years, there has been increasing interest in the clinical characteristics of CMI, its neural correlates and associated factors in pwMS, given that it has been considered a marker of daily life impairment. Although some neuroimaging studies suggest that there is increased activation in the prefrontal cortex and premotor cortex during dual tasking in pwMS, findings on whether pwMS have higher CMI than age-matched healthy controls are inconsistent (6)(7)(8). This may be due to the fact that varied dual-task paradigms have been used in studies or different baseline conditions of patients associated with diseases.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Dual-task Walking and Cognitive Functions in Persons with Multiple Sclerosis

Abasıyanık¹,

Yiğit²,

Karakas³

et al. 2023

jmrs

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Objective: Dual-task performance assessment is a holistic approach that incorporates both motor and cognitive assessment. However, there is scarce data on the relationship between dual-task walking and cognitive functions in persons with multiple sclerosis (pwMS). The aim was to investigate the relationship between dual-task walking and cognitive functions in pwMS. Materials and Methods:This study analyzed 156 patients (median age 35 years, 73.1% female). Timed Up and Go tests (TUG), with and without cognitive task (TUG), were performed to assess dual-task performance. Dual-task cost (DTC) was calculated. Cognitive information processing speed, visuospatial memory, and verbal memory were assessed using a Brief International Cognitive Assessment for MS (BICAMS). Results:The DTC was 11.8%. The TUG-cog tests were moderately correlated with all subtests of BICAMS (r=-0.322 to -0.440). However, DTC has a significant but small correlation with cognitive tests (r=0.227-0.254). Disability level was the significant predictor of dual-task performance. Conclusion:Our findings confirm that higher dual-task performance is significantly associated with better cognitive processing speed, visuospatial memory, and verbal memory in pwMS. This result may facilitate the use of dual-tasking paradigms in studies on cognitive impairment screening methods. However, such research undertakings should be supported by longitudinal studies.

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Neural correlates of dual-task walking in people with central neurological disorders: a systematic review

Cited by 11 publications

References 98 publications

Dual-task gait and white matter hyperintensities in Lewy body diseases: An exploratory analysis

Dual-task gait and white matter hyperintensities in Lewy body diseases: An exploratory analysis

Cognitive dual-task cost depends on the complexity of the cognitive task, but not on age and disease

Relationship Between Dual-task Walking and Cognitive Functions in Persons with Multiple Sclerosis

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