Neural correlates of cognitive control in gambling disorder: a systematic review of fMRI studies

Moccia, Lorenzo; Pettorruso, Mauro; Crescenzo, Franco De; Risio, Luisa De; Nuzzo, Luigi di; Martinotti, Giovanni; Bifone, Angelo; Janiri, Luigi; Nicola, Marco Di

doi:10.1016/j.neubiorev.2017.04.025

Cited by 134 publications

(63 citation statements)

References 161 publications

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“…A balanced dopaminergic transmission could be crucial in sustaining advantageous decision making. If the role of DAT down‐regulation in GD pathophysiology was to be further confirmed in future studies, this would advocate for treatments that seek to restore striatal dopaminergic transmission …”

Section: Discussionmentioning

confidence: 99%

“…Brain imaging techniques have allowed neuroscientists to map out the neural landscape of GD and explore how different stimuli modify it. Growing evidence implicates a failure in top‐down inhibitory prefrontal cortex (PFC) control over striatal outflow . The altered interaction between prefrontal structures and the mesolimbic reward system in GD shares similarities with the functional organization reported in substance addiction, suggesting a more general pathophysiology for addictive disorders …”

Section: Introductionmentioning

confidence: 95%

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Striatal presynaptic dopaminergic dysfunction in gambling disorder: A ¹²³I‐FP‐CIT SPECT study

et al. 2018

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Although the involvement of dopamine in gambling disorder (GD) has long been hypothesized, its precise role remains unclear. The action of dopamine in the synapses is regulated by the dopamine transporter (DAT). We hereinafter present significant differences between a sample of 15 treatment-seeking GD subjects and 17 healthy controls in terms of striatal DAT availability, and we explore its association with reward-based decision making. We performed I-FP-CIT Single-photon emission computed tomography (SPECT) and correlated DAT binding ratios in the bilateral caudate and putamen with gambling symptoms (G-SAS, PG-YBOCS) and behaviors, as well as other psychometric variables (anhedonia and impulsivity). Gambling disorder (GD) subjects were also administered a computerized version of the Iowa gambling task (IGT) to assess reward-based decision making. We found reduced DAT availability in GD subjects compared with healthy controls (-13.30% in right caudate, -11.11% in right putamen, -11.44% in left caudate, and -11.46% in the left putamen). We also found that striatal DAT availability was inversely correlated with days spent gambling and IGT performance in GD subjects. These results provide evidence for a presynaptic dopaminergic dysfunction in striatal regions of GD subjects. Functional DAT down-regulation possibly sustains the transition towards compulsive gambling addiction, characterized both by hyperdopaminergic and hypodopaminergic states in the context of a sensitized dopaminergic system.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Striatal presynaptic dopaminergic dysfunction in gambling disorder: A ¹²³I‐FP‐CIT SPECT study

et al. 2018

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“…Given the dysfunction of PFC revealed in drug addiction (Goldstein & Volkow, 2011), it stands to reason that a similar pattern of PFC abnormalities may exist in BAs. Evidence from an integrated review has suggested deficits of cognitive control in PG can be ascribed to the aberrant activation of PFC (Moccia et al, 2017).…”

Section: Shared Gm Atrophy In Individuals With Basmentioning

confidence: 99%

Shared gray matter alterations in individuals with diverse behavioral addictions: A voxel-wise meta-analysis

et al. 2020

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Background and aims Numerous studies on behavioral addictions (BAs) have reported gray matter (GM) alterations in multiple brain regions by using voxel-based morphometry (VBM). However, findings are poorly replicated and it remains elusive whether distinct addictive behaviors are underpinned by shared abnormalities. In this meta-analysis, we integrated VBM studies on different BAs to investigate common GM abnormalities in individuals with BAs. Methods We performed a systematic search up to January 2019 in several databases for VBM studies investigating GM differences between individuals with BAs and healthy controls. The reference lists of included studies and high-quality reviews were investigated manually. Anisotropic effect-size signed differential mapping was applied in this meta-analysis. Results Twenty studies including 505 individuals with BAs and 564 healthy controls met the inclusion criteria. Compared with healthy controls, individuals with BAs showed GM atrophy in the left anterior cingulate (extending to the left medial superior frontal gyrus and bilateral orbitofrontal gyrus), right putamen and right supplementary motor area. Subgroup analysis found heterogeneity in gender and subtypes of BAs. Meta-regression revealed that GM decreases in the left anterior cingulate and right supplementary motor area were positively correlated with addictive severity. Higher impulsivity was associated with smaller volume of the left anterior cingulate. Discussion and conclusions Our findings on BAs were mainly derived from internet gaming disorder (IGD) and pathological gambling (PG) studies, preliminarily suggesting that GM atrophy in the prefrontal and striatal areas might be a common structural biomarker of BAs.

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“…Furthermore, Billieux, Gay, Rochat and Van der Linden () observed, during the conduction of an experimental study, that some dimensions of impulsive characteristics (response inhibition and cognitive control) were partly related to GD due to their interaction with emotional arousal. This type of empirical evidence is further supported by data brought by the neurobiological field (Moccia et al ., ). In fact, some brain dysfunctions have been highlighted as potential factors that explain the pathways that link impulsive characteristics to GD.…”

Section: Introductionmentioning

confidence: 97%

“…In fact, some brain dysfunctions have been highlighted as potential factors that explain the pathways that link impulsive characteristics to GD. For example, the decrease in cognitive control and craving – two distinctive diagnostic signs of GD – embedded in the dysfunction of the ventromedial prefrontal cortex, probably interact with the processes involved in emotion regulation and emotional reactivity (Moccia et al ., ).…”

Section: Introductionmentioning

confidence: 99%

Pathological personality facets and emotion (dys)regulation in gambling disorder

Rogier

Zobel

Velotti

2019

Scandinavian J Psychology

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A number of researches showed high prevalence of personality disorders among addicted gamblers. However, there are still few studies investigating the role of pathological personality facets in Gambling Disorder (GD). Moreover, the nature of the relationship between GD and pathological personality is not clear. We administered to a group of addicted gamblers (N = 79) and a group of healthy participants (N = 101) a battery of self‐report questionnaires encompassing the South Oaks Gambling Screen (SOGS), The Personality Inventory for DSM‐V (PID‐5), the Difficulties in Emotion Regulation Scale (DERS) and the Emotion Regulation Questionnaire (ERQ). Analyses of variance showed that addicted gamblers, compared to healthy participants, scored higher on most of the subscales of the DERS, on the Suppression Dimension of the ERQ and on the five main domains of the PID‐5 whereas they obtained lower scores on the Reappraisal subscale of the ERQ. Moreover, multiple regression analyses indicated that some specific facets of pathological personality, emotion dysregulation and lack of cognitive reappraisal, significantly predict GD's severity. Finally, emotion dysregulation levels and lack of cognitive reappraisal partially mediated the relationship between these and GD's severity. Our results confirmed the central roles played by both pathological personality and deficit in emotion regulation capacities in GD. Specifically, Impulsivity, Lack of Perseverance and Suspiciousness may be important predictors of GD severity. Moreover, emotion dysregulation and lack of adaptive emotion regulation strategies partially explained such relationship. As such, training for emotion regulation abilities appears strategically useful in the treatment of addicted gamblers with pathological personality traits.

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Neural correlates of cognitive control in gambling disorder: a systematic review of fMRI studies

Cited by 134 publications

References 161 publications

Striatal presynaptic dopaminergic dysfunction in gambling disorder: A ¹²³I‐FP‐CIT SPECT study

Striatal presynaptic dopaminergic dysfunction in gambling disorder: A ¹²³I‐FP‐CIT SPECT study

Shared gray matter alterations in individuals with diverse behavioral addictions: A voxel-wise meta-analysis

Pathological personality facets and emotion (dys)regulation in gambling disorder

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Neural correlates of cognitive control in gambling disorder: a systematic review of fMRI studies

Cited by 134 publications

References 161 publications

Striatal presynaptic dopaminergic dysfunction in gambling disorder: A 123I‐FP‐CIT SPECT study

Striatal presynaptic dopaminergic dysfunction in gambling disorder: A 123I‐FP‐CIT SPECT study

Shared gray matter alterations in individuals with diverse behavioral addictions: A voxel-wise meta-analysis

Pathological personality facets and emotion (dys)regulation in gambling disorder

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Product

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Striatal presynaptic dopaminergic dysfunction in gambling disorder: A ¹²³I‐FP‐CIT SPECT study

Striatal presynaptic dopaminergic dysfunction in gambling disorder: A ¹²³I‐FP‐CIT SPECT study