Neural Correlates of Brain Reserve: A Neuroimaging Perspective

Abstract

Brain (BR) and Cognitive reserve (CR) are known to modulate the clinical features of Alzheimer's disease (AD). This is a critical issue especially in the absence of diseasemodifying treatments, but with non-pharmacological interventions available which might delay patients' cognitive disabilities. We reported here a selection of studies investigating the neurobiological substrate of BR and CR in patients with AD at different clinical stages.