Neural correlates of affective picture processing — A depth ERP study

Brázdil, Milan; Román, Róbert; Urbánek, Tomáš; Chládek, Jan; Spok, Dalilbor; Mareček, Radek; Mikl, Michal; Jurák, Pavel; Halámek, Josef; Daniel, Pavel; Rektor, Ivan

doi:10.1016/j.neuroimage.2009.03.081

Cited by 18 publications

(18 citation statements)

References 42 publications

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“…Insular activations have also been associated with the magnitude of the anticipated loss during gambling tasks (Canessa et al , 2013) and have been recorded while experiencing negative feedback (Kuhnen and Knutson, 2005). This is also consistent with several studies suggesting that the insula and the amygdala are more specifically related to negative but not positive emotional experience (Anders et al , 2004; Brázdil et al , 2009; Nielen et al , 2009). Particularly, the amygdala has been related to fear processing (Bechara et al , 1995; LaBar et al , 1995, 1998), while the insula cortex is thought to be involved in disgust (Calder et al , 2000; Adolphs et al , 2003; Stark et al , 2007).…”

Section: Discussionsupporting

confidence: 92%

Decision-making impairments following insular and medial temporal lobe resection for drug-resistant epilepsy

Siebenthal

Boucher

Rouleau

et al. 2016

Soc Cogn Affect Neurosci

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Besides the prefrontal cortex, the insula and medial structures of the temporal lobe are thought to be involved in risky decision-making. However, their respective contributions to decision processes remain unclear due to the lack of studies involving patients with isolated insular damage. We assessed adult patients who underwent resection of the insula (n = 13) or of the anterior temporal lobe (including medial structures) (n = 13) as part of their epilepsy surgery, and a group of healthy volunteers (n = 20), on the Iowa Gambling Task (IGT) and on the Cups Task. Groups were matched on sociodemographic, estimated-IQ and surgery-related factors. On the IGT, patients with temporal lobe resection performed significantly worse than both the insular and healthy control groups, as they failed to learn which decks were advantageous on the long-term. On the Cups Task, the insular and temporal groups both showed impaired sensitivity to expected value in the loss domain, when compared with healthy controls. These findings provide clinical evidence that the insula and mesiotemporal structures are specifically involved in risky decision-making when facing a potential loss, and that temporal structures are also involved in learning the association between behavior and consequences in the long-term.

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Section: Discussionsupporting

confidence: 92%

Decision-making impairments following insular and medial temporal lobe resection for drug-resistant epilepsy

Siebenthal

Boucher

Rouleau

et al. 2016

Soc Cogn Affect Neurosci

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“…The few prior studies reporting field potentials 12,14 or oscillatory responses 11,35 from human amygdala depth recordings failed to find the fast-latency amygdala response that we observed. Although two previous studies 35,36 also presented fearful faces, they found responses at ~130 ms (approximating the latency of the main effect of emotion that we observed in the amygdala) and used only standard broadband photographs.…”

Section: Discussioncontrasting

confidence: 78%

“…1). No statistical methods were used to pre-determine sample sizes but our sample sizes are larger to those reported in previous publications [11][12][13][14]35 . All patients signed informed consent.…”

Section: Methodsmentioning

confidence: 88%

“…Evidence for a fast pathway in humans has only been inferred indirectly from neuroimaging studies in healthy individuals 4,5 that used subconscious emotional stimulus presentation during functional magnetic resonance imaging (fMRI) 6,7 and in cortically blind patients who showed preserved processing of unseen visual fear-related stimuli 8,9 , possibly mediated by intact fiber connections between pulvinar, superior colliculus and amygdala 10 , after damage to visual occipital areas. However, given a lack of direct electrophysiological evidence for short-latency fear-related responses in human amygdala [11][12][13][14] , an alternative to the low-road model suggests that some cortical regions may be equally fast at processing fear as the amygdala 15,16 . We addressed this controversy by presenting emotional (fearful, happy) and neutral faces to patients with medication-resistant epilepsy in whom stereotactic electrodes had been implanted in the amygdala for pre-surgical evaluation. The faces were presented either as normal photographs (broad spatial frequency, BSF) or were spatially filtered such that only their low (LSF) or high (HSF) spatial frequency components were displayed (Fig.…”

mentioning

confidence: 99%

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A fast pathway for fear in human amygdala

et al. 2016

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A fast, subcortical pathway to the amygdala is thought to have evolved to enable rapid detection of threat. This pathway's existence is fundamental for understanding nonconscious emotional responses, but has been challenged as a result of a lack of evidence for short-latency fear-related responses in primate amygdala, including humans. We recorded human intracranial electrophysiological data and found fast amygdala responses, beginning 74-ms post-stimulus onset, to fearful, but not neutral or happy, facial expressions. These responses had considerably shorter latency than fear responses that we observed in visual cortex. Notably, fast amygdala responses were limited to low spatial frequency components of fearful faces, as predicted by magnocellular inputs to amygdala. Furthermore, fast amygdala responses were not evoked by photographs of arousing scenes, which is indicative of selective early reactivity to socially relevant visual information conveyed by fearful faces. These data therefore support the existence of a phylogenetically old subcortical pathway providing fast, but coarse, threat-related signals to human amygdala.

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“…Furthermore, experience of mirth has been evoked by EBS of left inferior temporal lobe, left inferior frontal gyrus, supplementary motor area, cingulate gyrus, parahippocampal and fusiform gyri (Table 1). Further evidence comes from ERP studies showing for instance that the hippocampus, amygdala, pre-frontal cortex, insula and precuneus activate during presentation of fearful stimuli (Brázdil et al, 2009 (Tables 2 and 3). However, HIE studies do not suggest absolute separation of emotional valence by hemisphere, only dominance.…”

Section: Discussionmentioning

confidence: 99%

Exploring emotions using invasive methods: review of 60 years of human intracranial electrophysiology

Guillory

Bujarski

2014

Social Cognitive and Affective Neuroscience

107

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Over the past 60 years, human intracranial electrophysiology (HIE) has been used to characterize seizures in patients with epilepsy. Secondary to the clinical objectives, electrodes implanted intracranially have been used to investigate mechanisms of human cognition. In addition to studies of memory and language, HIE methods have been used to investigate emotions. The aim of this review is to outline the contribution of HIE (electrocorticography, single-unit recording and electrical brain stimulation) to our understanding of the neural representations of emotions. We identified 64 papers dating back to the mid-1950s which used HIE techniques to study emotional states. Evidence from HIE studies supports the existence of widely distributed networks in the neocortex, limbic/paralimbic regions and subcortical nuclei which contribute to the representation of emotional states. In addition, evidence from HIE supports hemispheric dominance for emotional valence. Furthermore, evidence from HIE supports the existence of overlapping neural areas for emotion perception, experience and expression. Lastly, HIE provides unique insights into the temporal dynamics of neural activation during perception, experience and expression of emotional states. In conclusion, we propose that HIE techniques offer important evidence which must be incorporated into our current models of emotion representation in the human brain.

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Neural correlates of affective picture processing — A depth ERP study

Cited by 18 publications

References 42 publications

Decision-making impairments following insular and medial temporal lobe resection for drug-resistant epilepsy

Decision-making impairments following insular and medial temporal lobe resection for drug-resistant epilepsy

A fast pathway for fear in human amygdala

Exploring emotions using invasive methods: review of 60 years of human intracranial electrophysiology

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