Neural correlates of a reversal learning task with an affectively neutral baseline: An event-related fMRI study

Remijnse, Peter L.; Nielen, M.; Uylings, H.B.M.; Veltman, Dick J.

doi:10.1016/j.neuroimage.2005.02.009

Cited by 142 publications

(143 citation statements)

References 62 publications

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“…Interestingly, this study found significantly increased ventrolateral PFC BOLD responding to both acquisition errors, and rewarded errors (probabilistic errors) during acquisition (i.e., even when no punishment information was received) [16]. Other decision-making studies have also observed increased activity to reward in lateral inferior frontal cortex [2,25], and caudate [26,27]. On the basis of these data, these regions cannot be considered to simply represent punishment.…”

Section: Discussionsupporting

confidence: 48%

“…Previous studies of reversal learning have implicated lateral regions of orbitofrontal or ventrolateral PFC in representing punishment [2,6], response change following punishment [1], or the suppression of previously rewarded responses [5,13,14]. If the ventrolateral PFC supports response reversal by inhibiting representations of acquired response options (reducing perseverative responding in particular), greater activity in this region should be observed to response reversal errors over errors during acquisition (before a prepotent response is acquired).…”

Section: Discussionmentioning

confidence: 99%

“…Most studies of reversal learning require reversals of a single pair of objects [1][2][3]. In our study, as in more complex forms of decision-making, subjects were required to make multiple stimulus discriminations and to change their responses for only some of these discriminations in the reinforcement shift phase (for 2 out of the 5 discriminations).…”

Section: Discussionmentioning

confidence: 99%

“…Regions of medial (BA 10), ventrolateral, and dorsomedial prefrontal cortex (PFC) have been implicated in altering behaviour when the reward value of available response options change [1][2][3][4]. This phenomenon, referred to as "response reversal," likely consists of functionally distinct components such as stimulus value representation, response inhibition, response selection, and response initiation.…”

Section: Introductionmentioning

confidence: 99%

“…Neuroimaging studies involving response reversal also show activity in dorsolateral regions of PFC [2,10]; however, the functional significance of this activity has been given less consideration. Its role is particularly unclear as human and non-human lesion studies strongly suggest that dorsolateral PFC is not necessary for response reversal [17,18].…”

Section: Introductionmentioning

confidence: 99%

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The contribution of ventrolateral and dorsolateral prefrontal cortex to response reversal

Mitchell

Rhodes

Pine

et al. 2008

Behavioural Brain Research

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Studies investigating response reversal consistently implicate regions of medial and lateral prefrontal cortex when reinforcement contingencies change. However, it is unclear from these studies how these regions give rise to the individual components of response reversal, such as reinforcement value encoding, response inhibition, and response change. Here we report a novel instrumental learning task designed to determine whether regions implicated in processing reversal errors are uniquely involved in this process, or whether they play a more general role in representing response competition, reinforcement value, or punishment value in the absence of demands for response change. In line with previous findings, reversal errors activated orbitofrontal cortex, dorsomedial prefrontal cortex, ventrolateral prefrontal cortex, caudate, and dorsolateral prefrontal cortex. These regions also showed increased activity to errors in the absence of contingency changes. In addition, ventrolateral PFC, caudate, and dorsolateral PFC each exhibited increased activity following correct reversals. Activity in these regions was not significantly modulated by changes in reinforcement value that were not sufficient to make an alternative response advantageous. These data do not support punishment-processing or prepotent reponse inhibition accounts of ventrolateral prefrontal cortex function. Instead, they support recent conceptualizations of ventrolateral prefrontal cortex function that implicate this region in resolving response competition by manipulating the representation of either motor response options, or object features. These data also suggest that dorsolateral prefrontal cortex plays a role in reversal learning, probably through top down attentional control of object or reinforcement features when task demands increase.

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Section: Discussionsupporting

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The contribution of ventrolateral and dorsolateral prefrontal cortex to response reversal

Mitchell

Rhodes

Pine

et al. 2008

Behavioural Brain Research

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Reduced Orbitofrontal-Striatal Activity on a Reversal Learning Task in Obsessive-Compulsive Disorder

Remijnse¹,

Nielen²,

Balkom³

et al. 2006

Arch Gen Psychiatry

372

291

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Abnormal Ventromedial Prefrontal Cortex Function in Children With Psychopathic Traits During Reversal Learning

Finger

Marsh

Mitchell³

et al. 2008

Arch Gen Psychiatry

334

321

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To our knowledge, this study provides the first evidence of abnormal ventromedial prefrontal cortex responsiveness in children with psychopathic traits and demonstrates this dysfunction was not attributable to comorbid attention-deficit/hyperactivity disorder. These findings suggest that reversal learning impairments in patients with developmental psychopathic traits relate to abnormal processing of reinforcement information.

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Neural correlates of a reversal learning task with an affectively neutral baseline: An event-related fMRI study

Cited by 142 publications

References 62 publications

The contribution of ventrolateral and dorsolateral prefrontal cortex to response reversal

The contribution of ventrolateral and dorsolateral prefrontal cortex to response reversal

Reduced Orbitofrontal-Striatal Activity on a Reversal Learning Task in Obsessive-Compulsive Disorder

Abnormal Ventromedial Prefrontal Cortex Function in Children With Psychopathic Traits During Reversal Learning

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