“…More specifically, insular cortex damage has been associated with cardiac arrhythmia, disruption of physiological diurnal blood pressure variations (e.g. a nondipper or riser pattern), myocardial injury and breathing-related sleep disorders, as well as higher plasma levels of brain natriuretic peptide, catecholamines and glucose [12,13]. Moreover, the paraventricular nucleus of the hypothalamus was seen to be one of the most important central sites involved in regulating sympathetic tone and is, in part, responsible for the evident dysregulation of the sympathetic nervous system in heart failure [1].…”