Neural control of pancreatic peptide hormone secretion

Verberne, Anthony J.M.; Mussa, Bashair M

doi:10.1016/j.peptides.2022.170768

Cited by 3 publications

(3 citation statements)

References 159 publications

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“…The autonomic nervous system is a critical component of the peripheral nervous system responsible for regulating involuntary physiological functions, such as heart rate, blood pressure, digestion, and respiratory rate. Emerging evidence suggests that orexin also plays a significant role in modulating the autonomic nervous system and it has been shown to influence the activity of both the sympathetic [34] and parasympathetic [35] nervous systems [36]. Moreover, orexin is involved in the regulation of the cardiovascular [34] and respiratory [37] functions through its actions on the autonomic nervous system.…”

Section: Regulation Of the Autonomic Nervous Systemmentioning

confidence: 99%

Rethinking the Role of Orexin in the Regulation of REM Sleep and Appetite

Mogavero,

Godos,

Grosso

et al. 2023

Nutrients

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Orexin plays a significant role in the modulation of REM sleep, as well as in the regulation of appetite and feeding. This review explores, first, the current evidence on the role of orexin in the modulation of sleep and wakefulness and highlights that orexin should be considered essentially as a neurotransmitter inhibiting REM sleep and, to a much lesser extent, a wake promoting agent. Subsequently, the relationship between orexin, REM sleep, and appetite regulation is examined in detail, shedding light on their interconnected nature in both physiological conditions and diseases (such as narcolepsy, sleep-related eating disorder, idiopathic hypersomnia, and night eating syndrome). Understanding the intricate relationship between orexin, REM sleep, and appetite regulation is vital for unraveling the complex mechanisms underlying sleep-wake patterns and metabolic control. Further research in this field is encouraged in order to pave the way for novel therapeutic approaches to sleep disorders and metabolic conditions associated with orexin dysregulation.

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Section: Regulation Of the Autonomic Nervous Systemmentioning

confidence: 99%

Rethinking the Role of Orexin in the Regulation of REM Sleep and Appetite

Mogavero,

Godos,

Grosso

et al. 2023

Nutrients

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“…is added to block hepatic glucose production. However, in step 4, only full insulinization is performed with basal and prandial insulins, since the pancreatic β cells stop producing the hormone (Verberne & Mussa, 2022). It is important to mention that throughout all treatment stages, lifestyle changes are recommended, such as healthy eating and physical exercise (Knudsen, et al, 2020).…”

Section: Medicationsmentioning

confidence: 99%

“…The effects of insulin are antagonized by hormones such as adrenaline (via α2 adrenergic receptors), glucocorticoids, insulin itself, and growth hormone (somatostatin) by decreasing the affinity of insulin receptors. However, the stimulation of β2-adrenergic receptors, vagus nerve activity, and the action of incretins enhance insulin release (Verberne & Mussa, 2022).…”

Section: Insulinmentioning

confidence: 99%

A minireview of pharmacotherapy of type 2 diabetes – drugs and mechanisms

Lima

Godoy

Araújo

2022

RSD

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Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that originates from numerous pathogenic mechanisms, all of which result in hyperglycemia. This disease is a major cause of morbidity and mortality worldwide. Effective prevention and treatment strategies for T2DM are therefore necessary. The purpose of this review was to summarize the pharmacotherapy for patients with T2DM by discussing its pathophysiology, the therapeutic classes used in treatment strategies, as well as the mechanisms of action for each one. A literature review was conducted by searching Google Scholar, PubMed, and Science Direct databases using the search terms: type 2 diabetes mellitus, insulin, AMPK, antidiabetic drugs, incretin, SGLT2, and biguanides covering studies up to 2022. The review identified and included studies including qualitative, original research articles, and randomized controlled trial designs. The results of this study are divided into drugs that increase insulin sensitivity (e.g., biguanides, and thiazolidinediones), secretagogues (e.g., sulfonylureas, and meglitinides or glinides), incretin mimetics drugs (e.g., GLP-1 receptor agonists, and DPP-4 inhibitors), drugs that cause glycosuria (e.g., SGLT2 inhibitors), drugs that prevent glucose absorption (e.g., α-glucosidase inhibitor), and insulin. This allows the readers to understand each process while keeping the paper concise.

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