Neural conduction in the visual pathways in ocular hypertension and glaucoma

Parisi, Vincenzo

doi:10.1007/bf00941720

Cited by 42 publications

(64 citation statements)

References 29 publications

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“…[1][2][3][4][5] The PERG stimulus isolates the ganglion cell response by using a reversing (ie, contrast modulated) checkerboard or grating pattern that carries no change in overall luminance over time (space-averaged luminance). If the PERG response is measuring retinal ganglion cell activity, it should be associated with the number of retinal ganglion cells.…”

Section: Introductionmentioning

confidence: 99%

Pattern electroretinogram association with spectral domain-OCT structural measurements in glaucoma

Bowd

Tafreshi

Zangwill

et al. 2010

Eye

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Purpose To describe the association between pattern electroretinogram (PERG) amplitude and spectral domain-optical coherence tomography (SD-OCT) macular thickness, retinal nerve fibre layer (RNFL) thickness and optic disc topography measurements. Subjects and methods Both eyes (n ¼ 132) of 66 glaucoma patients (mean age ¼ 67.9 years) enroled in the University of California, San Diego, CA, USA, Diagnostic Innovations in Glaucoma Study (DIGS) were included. Eyes were tested with PERG (Glaid PERGLA, Lace Elettronica, Pisa, Italy), RTVue SD-OCT (Optovue Inc., Fremont, CA, USA) GCC, and NHM4 protocols on the same day. Of the 66 enroled patients, 43 had glaucoma defined by repeated abnormal standard automated perimetry (SAP) results in at least one eye and 23 were glaucoma suspects defined by a glaucomatous-appearing optic disc by physicians' examination in at least one eye and normal SAP results in both eyes. Associations (R 2 ) were determined between PERG amplitude (lV) and SD-OCT macular ganglion cell complex (GCC) thickness (lm), macular thickness (lm), macular outer retinal thickness (macular thickness minus GCC thickness) (lm), RNFL thickness (lm), neuroretinal rim area (mm 2 ), and rim volume (mm 3 ). Results PERG amplitude was significantly associated with GCC thickness (R 2 ¼ 0.179, Po0.001), RNFL thickness (R 2 ¼ 0.174, Po0.001), and macular thickness (R 2 ¼ 0.095, Po0.001). R 2 associations with other parameters were not significant (all P40.624). Significant associations remained for GCC and average RNFL thickness when age and intraocular pressure at the time of testing were included in multivariate models (both Pr0.030). Conclusions PERG amplitude is significantly (but weakly) associated with macular GCC thickness, RNFL thickness, and macular thickness. The lack of association between PERG amplitude and macular outer retinal thickness supports previous results, possibly suggesting that that the PERG is driven primarily by retinal ganglion cell (inner retinal) responses.

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Section: Introductionmentioning

confidence: 99%

Pattern electroretinogram association with spectral domain-OCT structural measurements in glaucoma

Bowd

Tafreshi

Zangwill

et al. 2010

Eye

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“…Previous electrophysiologic evidence [17,18,19] indicated that the impaired PRVEP responses observed in POAG patients could be ascribed to impaired neural conduction in the optic nerve and in the whole post retinal visual pathways as a consequence of the dysfunction of the innermost retinal layers.…”

Section: Discussionmentioning

confidence: 99%

Comparative evaluation of Optical Coherence Tomography (OCT) with Pattern Reversal Visual Evoked Potential (PRVEP) in early primary open angle glaucoma

Taksande¹,

Rawekar²,

Sune³

2017

IJB

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Present study is to correlate the average retinal nerve fiber layer (RNFL) thickness and the visual function evaluated by electrophysiologic retinal and cortical responses assessed in primary open-angle glaucoma (POAG) eyes by a Case-control study. One hundred and sixty-one control and glaucoma patients (mean age, 55.18±5.19 years for study group and 54.45±4.81 years for control group) were selected in the study. Average Retinal Nerve fiber layer thickness was measured by optical coherence tomography. Retinal and visual pathway function was assessed by simultaneously recording pattern reversal visual evoked potentials (PRVEPs) Linear regression analyses were adopted to establish the correlation between average RNFL thickness and PRVEP parameters. Average Retinal Nerve fiber layer thickness were taken. PRVEP, P100 latency and N75-P100 amplitude were also measured. In POAG eyes, we found a significant (P< 0.01) reduction in average RNFL thickness with respect to the values observed in control eyes. PRVEP parameters showed a significant (p< 0.01) delay in p100 latency and reduced N75 p100 amplitude. Positive correlations between average RNFL values and PRVEP parameters were found. There is a positive correlation between PRVEP changes and average RNFL thickness, in POAG patients.

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“…Therefore, axonal and dendritic pathology are early signs in disease and providing new insights into therapeutic strategies. Increased latency and reduced amplitude of visual evoked potentials, frequently encountered in ocular hypertension or POAG, suggest slowed neural conduction in the visual pathways (Parisi 1997;Bach and Hoffmann 2008). Recent research in monkeys demonstrated that the glaucomatous damage extends from the retina to the visual centers in the brain, but being the primary region of damage the optic nervehead, with the lateral geniculate nucleus being secondarily affected.…”

Section: Glaucoma Visual Loss and Apoptosismentioning

confidence: 99%

Glaucoma Genetics – Regulation of Cell Surviving and Death in the Retina

Pinazo-Durán¹,

Gallego-Pinazo²,

Zanón‐Moreno³

et al. 2011

Glaucoma - Basic and Clinical Concepts

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Neural conduction in the visual pathways in ocular hypertension and glaucoma

Abstract: Our results suggest that involvement of the innermost retinal layers in POAG is accompanied by slowed neural conduction in the visual pathways.

Cited by 42 publications

References 29 publications

Pattern electroretinogram association with spectral domain-OCT structural measurements in glaucoma

Pattern electroretinogram association with spectral domain-OCT structural measurements in glaucoma

Comparative evaluation of Optical Coherence Tomography (OCT) with Pattern Reversal Visual Evoked Potential (PRVEP) in early primary open angle glaucoma

Glaucoma Genetics – Regulation of Cell Surviving and Death in the Retina

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