Neural basis of visual perception and reasoning ability in Alzheimer's disease: correlation between Raven's Colored Progressive Matrices test and <sup>123</sup>I‐IMP SPECT imaging results

Yoshida, Taku; Mori, Takaaki; Shimizu, Hideaki; Yoshino, Yuta; Sonobe, Naomi; Matsumoto, Teruhisa; Kikuchi, Keiichi; Miyagawa, Masao; Iga, Jun‐ichi; Mochizuki, Takashi; Ueno, Shu‐ichi

doi:10.1002/gps.4481

Cited by 10 publications

(5 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, we demonstrated an association between connectivity impairment in prefrontal regions and visuospatial/logical reasoning performance, as measured by Ravens' Colored Progressive Matrices score. The association between visuospatial/logical reasoning and dorsolateral prefrontal cortex has been shown by several fMRI studies in healthy subjects (Krawczyk, Michelle McClelland, & Donovan, 2011;Kroger et al, 2002) and in patients with neurodegenerative dementias (Yoshida et al, 2017). Our results provide further evidence for an association between executive dysfunction and frontal connectivity impairment in DLB, consistent with previous hypotheses (Lee et al, 2010;Sourty et al, 2016).…”

Section: Neuropsychological Deficitssupporting

confidence: 91%

Vulnerability of multiple large‐scale brain networks in dementia with Lewy bodies

Sala

Caminiti

Iaccarino

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

Aberrations of large‐scale brain networks are found in the majority of neurodegenerative disorders. The brain connectivity alterations underlying dementia with Lewy bodies (DLB) remain, however, still elusive, with contrasting results possibly due to the pathological and clinical heterogeneity characterizing this disorder. Here, we provide a molecular assessment of brain network alterations, based on cerebral metabolic measurements as proxies of synaptic activity and density, in a large cohort of DLB patients (N = 72). We applied a seed‐based interregional correlation analysis approach (p < .01, false discovery rate corrected) to evaluate large‐scale resting‐state networks' integrity and their interactions. We found both local and long‐distance metabolic connectivity alterations, affecting the posterior cortical networks, that is, primary visual and the posterior default mode network, as well as the limbic and attention networks, suggesting a widespread derangement of the brain connectome. Notably, patients with the lowest visual and attention cognitive scores showed the most severe connectivity derangement in regions of the primary visual network. In addition, network‐level alterations were differentially associated with the core clinical manifestations, namely, hallucinations with more severe metabolic dysfunction of the attention and visual networks, and rapid eye movement sleep behavior disorder with alterations of connectivity of attention and subcortical networks. These multiple network‐level vulnerabilities may modulate the core clinical and cognitive features of DLB and suggest that DLB should be considered as a complex multinetwork disorder.

show abstract

Section: Neuropsychological Deficitssupporting

confidence: 91%

Vulnerability of multiple large‐scale brain networks in dementia with Lewy bodies

Sala

Caminiti

Iaccarino

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…In AD, predominant left hemisphere hypoperfusion/hypometabolism (including in the LP region) as indexed by SPECT/positron emission tomography was reported to be positively correlated with verbal deficits such as verbal and logical memory, word‐pair learning, and reading 45,46 . In contrast, predominant right hemisphere hypoperfusion (including in the IPL) was reported to be positively correlated with scores on neuropsychological tests of visual memory and visuospatial cognition in MCI 47,48 . However, in the present study, we observed no significant differences in neuropsychological test results between the LLP hypoperfusion (+) and RLP hypoperfusion (+) groups.…”

Section: Discussioncontrasting

confidence: 88%

“…45,46 In contrast, predominant right hemisphere hypoperfusion (including in the IPL) was reported to be positively correlated with scores on neuropsychological tests of visual memory and visuospatial cognition in MCI. 47,48 However, in the present study, we observed no significant differences in neuropsychological test results between the LLP hypoperfusion (+) and RLP hypoperfusion (+) groups. These negative findings may be partially attributed to the insensitivity of the neuropsychological tests used in this study to determine LLP and RLP differences.…”

Section: Discussioncontrasting

confidence: 82%

Effect of different parietal hypoperfusion on neuropsychological characteristics in mild cognitive impairment

et al. 2021

View full text Add to dashboard Cite

Background In early‐stage amnestic mild cognitive impairment (aMCI), differences in the neuropsychological characteristics of each individual are subtle. We investigated differences in neuropsychological performance between aMCI patients with and without hypoperfusion in the medial parietal regions (MP). We further compared patients with hypoperfusion in the left and right lateral parietal regions. Methods We examined 165 aMCI patients (mean age: 76.8 ± 5.5 years; 87 women) who had undergone neuropsychological measurement and single‐photon emission computed tomography. We classified participants into two subgroups with and without hypoperfusion: MP hypoperfusion (+) and MP hypoperfusion (−); classification was based on Z‐scores (calculated by three‐dimensional stereotactic surface projection technique) of three regions of interest in the parietal lobes (i.e. MP regions including posterior cingulate cortex and precuneus and left and right inferior parietal lobules (lateral parietal regions)). The MP hypoperfusion (−) group was classified into left lateral parietal hypoperfusion (+) and right lateral parietal hypoperfusion (+) subgroups. We performed either univariate or multivariate ancova to compare neuropsychological scores for continuous variables between groups and examined dichotomous variables using χ2 tests. Results In the overall aMCI sample, scores on logical memory delayed recall in the MP hypoperfusion (+) group were significantly lower than those in the MP hypoperfusion (−) group. Total scores on Rey‐Osterrieth Complex Figure Test delayed recall were also marginally lower in the MP hypoperfusion (+) group than in the MP hypoperfusion (−) group. Comparisons of neuropsychological test scores between the left and right lateral parietal hypoperfusion (+) groups revealed no significant differences. Conclusions The present findings suggest that MP hypoperfusion (+) is associated with more robust memory deficits than MP hypoperfusion (−). Combining neuropsychological tests and single‐photon emission computed tomography findings may be useful for early detection of cognitive decline in aMCI.

show abstract

“…RPM is a sensitive measure for cognitive sequelae of stroke and dementia [25]. Iodoamphetamine single-photon emission computed tomography (I-IMP SPECT) studies have shown that RPM scores are positively correlated with regional cerebral blood flow in various lobes [26]. Perhaps the impaired cerebral vascular regulation seen in those with low haemoglobin may explain this reduction in RPM scores.…”

Section: Discussionmentioning

confidence: 99%

Haemoglobin Concentration and Cognitive Ability in the Aberdeen Children of the 1950s

Bashir¹,

McNeil²,

Rasul³

et al. 2022

Cureus

View full text Add to dashboard Cite

IntroductionHaemoglobin concentrations decrease with age. Abnormally low and high haemoglobin concentrations are associated with reduced cognition; however, the evidence for these associations in cohort data is limited. This study aims to assess the relationship between haemoglobin concentration and cognition in a well-characterised cohort of older adults. MethodsTwo hundred and fifty-two healthy participants were drawn from the Aberdeen Children of the 1950s cohort, aged between 59 to 65 years. Participants underwent cognitive tests of processing speed, memory, verbal and nonverbal reasoning, and language ability and these were used to construct a global cognitive score, g, using principal component analysis. Haemoglobin concentration in the blood was measured concurrently. Hierarchical multiple regression models were constructed assessing the relationship between haemoglobin concentration and each cognitive measure and these were corrected for age, sex, education, C-reactive protein, hypertension, and body mass index. ResultsSignificant linear association between haemoglobin concentration and nonverbal reasoning demonstrated that low haemoglobin levels are associated with lower scores. A quadratic relationship was found for haemoglobin concentration and immediate memory scores in which low and high haemoglobin levels were associated with lower scores. ConclusionsHaemoglobin concentration was found to have a significant linear association with nonverbal reasoning scores and a significant quadratic association with memory scores. The results from this study help to understand the association between haemoglobin and different aspects of cognition.

show abstract

Neural basis of visual perception and reasoning ability in Alzheimer's disease: correlation between Raven's Colored Progressive Matrices test and ¹²³I‐IMP SPECT imaging results

Abstract: Our findings suggest that deteriorations of specific brain regions are associated with dysfunction of visual perception and reasoning ability in AD. RCPM is another informative assessment scale of cognition for use in patients with AD. Copyright © 2016 John Wiley & Sons, Ltd.

Cited by 10 publications

References 31 publications

Vulnerability of multiple large‐scale brain networks in dementia with Lewy bodies

Vulnerability of multiple large‐scale brain networks in dementia with Lewy bodies

Effect of different parietal hypoperfusion on neuropsychological characteristics in mild cognitive impairment

Haemoglobin Concentration and Cognitive Ability in the Aberdeen Children of the 1950s

Contact Info

Product

Resources

About

Neural basis of visual perception and reasoning ability in Alzheimer's disease: correlation between Raven's Colored Progressive Matrices test and 123I‐IMP SPECT imaging results

Abstract: Our findings suggest that deteriorations of specific brain regions are associated with dysfunction of visual perception and reasoning ability in AD. RCPM is another informative assessment scale of cognition for use in patients with AD. Copyright © 2016 John Wiley & Sons, Ltd.

Cited by 10 publications

References 31 publications

Vulnerability of multiple large‐scale brain networks in dementia with Lewy bodies

Vulnerability of multiple large‐scale brain networks in dementia with Lewy bodies

Effect of different parietal hypoperfusion on neuropsychological characteristics in mild cognitive impairment

Haemoglobin Concentration and Cognitive Ability in the Aberdeen Children of the 1950s

Contact Info

Product

Resources

About

Neural basis of visual perception and reasoning ability in Alzheimer's disease: correlation between Raven's Colored Progressive Matrices test and ¹²³I‐IMP SPECT imaging results