Neural basis of positive and negative emotion regulation in remitted depression

Kleef, Rozemarijn Surya van; Marsman, Jan-Bernard C; Valen, Evelien van; Bockting, Claudi; Alemán, André; Tol, Marie-José van

doi:10.1016/j.nicl.2022.102988

Cited by 15 publications

(18 citation statements)

References 129 publications

(169 reference statements)

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“…Global infra-slow neural activity related to the self modulates negative emotion regulation Our behavioral data confirm previous findings [49,50] of abnormally increased emotion severity during attention and reappraisal. These findings suggest abnormal cognitive-emotion regulation in MDD which is a well established observation [51,52]. Importantly, applying a complex statistical model extending beyond simple correlation analyses, namely multinomial regression analyses, we were able to link those behavioral findings to the global brain activity.…”

Section: Discussionmentioning

confidence: 64%

Abnormal global signal topography of self modulates emotion dysregulation in major depressive disorder

et al. 2023

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Major depressive disorder (MDD) is a complex mental disorder featured by an increased focus on the self and emotion dysregulation whose interaction remains unclear, though. At the same time, various studies observed abnormal representation of global fMRI brain activity in specifically those regions, e.g., cortical midline structure (CMS) in MDD that are associated with the self. Are the self and its impact on emotion regulation related to global brain activity unevenly represented in CMS relative to non-CMS? Addressing this yet open question is the main goal of our study. We here investigate post-acute treatment responder MDD and healthy controls in fMRI during an emotion task involving both attention and reappraisal of negative and neutral stimuli. We first demonstrate abnormal emotion regulation with increased negative emotion severity on the behavioral level. Next, focusing on a recently established three-layer topography of self, we show increased representation of global fMRI brain activity in specifically those regions mediating the mental (CMS) and exteroceptive (Right temporo-parietal junction and mPFC) self in post-acute MDD during the emotion task. Applying a complex statistical model, namely multinomial regression analyses, we show that increased global infra-slow neural activity in the regions of the mental and exteroceptive self modulates the behavioral measures of specifically negative emotion regulation (emotion attention and reappraisal/suppression). Together, we demonstrate increased representation of global brain activity in regions of the mental and exteroceptive self, including their modulation of negative emotion dysregulation in specifically the infra-slow frequency range (0.01 to 0.1 Hz) of post-acute MDD. These findings support the assumption that the global infra-slow neural basis of the increased self-focus in MDD may take on the role as basic disturbance in that it generates the abnormal regulation of negative emotions.

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Section: Discussionmentioning

confidence: 64%

Abnormal global signal topography of self modulates emotion dysregulation in major depressive disorder

et al. 2023

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“…Similar to previous task-related fMRI meta-analyses of rMDD patients (Wang et al, 2022), our results presented that compared with HCs, patients with rMDD showed significantly abnormal neural activaty in the left inferior parietal gyrus, left SFG, and right MTG, which play an important role in sensory perception, emotional control and cognitive functions, respectively. At present, the emotion regulation theory (van Kleef et al, 2022), and the cognitive model theory (Disner et al, 2011) are main hypotheses about the neuropathological mechanism of depression. Specifically, the left inferior parietal gyrus, SFG and MTG contribute to emotional control and cognitive function in MDD patients (Gong et al, 2020; Zheng et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, the left inferior parietal gyrus, SFG and MTG contribute to emotional control and cognitive function in MDD patients (Gong et al, 2020; Zheng et al, 2021). For rMDD individuals, stress may trigger a potential dysfunctional schema, in which the way of external and internal information is changed such that MDD patients prefer information with a certain emotional valence (or find such information aversive) in cognitive bias, thus promoting the recurrence of depressive mood states (Beck, 2008; van Kleef et al, 2022). Dysfunctional regulatory control and cognitive function may then prolong the experience of negative emotion, leading patients to spiral into a persistent depressed mood and finally a new depressive episode (Berking et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Thanks to better public understanding of MDD and improvements in medical technology, many people suffering from MDD have been able to find complete relief through systematic treatment (Smoski et al, 2013; Wang et al, 2022). Although patients with MDD have shown improvement according to a clinical symptom evaluation, individuals with remitted MDD (rMDD) still demonstrate differences in cognitive function, neuroimaging, and metabolism when compared to healthy controls (HCs) (Moriarty et al, 2022; van Kleef et al, 2022). These comparisons may assist in identifying patients at risk for relapse and improving preventive treatment.…”

Section: Introductionmentioning

confidence: 99%

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Common And Distinct Patterns Of Task-Related Neural Activation Abnormalities In Patients With Remitted And Current Major Depressive Disorder: A Systematic Review And Coordinate-Based Meta-Analysis

Wang

et al. 2023

Preprint

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Whether remitted major depressive disorder (rMDD) and MDD present common or distinct neuropathological mechanisms remains unclear. We performed a meta-analysis of task-related whole-brain functional magnetic resonance imaging (fMRI) using anisotropic effect-size signed differential mapping software to compare brain activation between rMDD/MDD patients and healthy controls (HCs). We included 18 rMDD studies (458 patients and 476 HCs) and 120 MDD studies (3746 patients and 3863 HCs). The results showed that MDD and rMDD patients shared increased neural activation in the right temporal pole and right superior temporal gyrus. Several brain regions, including the right middle temporal gyrus, left inferior parietal, prefrontal cortex, left superior frontal gyrus and striatum, differed significantly between MDD and rMDD. Meta-regression analyses revealed that the percentage of females with MDD was positively associated with brain activity in the right lenticular nucleus/putamen. Our meta-analysis provides useful insights for understanding the potential neuropathology of brain dysfunction in MDD, developing more targeted and efficacious treatment and intervention strategies, and more importantly, providing potential neuroimaging targets for early screening of MDD.

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“…fMRI task. Participants performed an emotion processing and regulation task 41 . Behavioral results are available at Zenodo 39 .…”

Section: Mri Data Acquisitionmentioning

confidence: 99%

A behavioral and brain imaging dataset with focus on emotion regulation of women with fibromyalgia

et al. 2022

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Fibromyalgia is a chronic condition characterized by widespread pain, as well as numerous symptoms related to central sensitization such as: fatigue, cognitive disturbances, constipation/diarrhea and sensory hypersensitivity. Furthermore, depression and anxiety are prevalent comorbidities, accompanied by emotion processing and regulation difficulties. Although fibromyalgia physiopathology is still not fully understood, neuroimaging research methods have shown brain structural and functional alterations as well as neuroinflammation abnormalities. We believe that open access to data may help fibromyalgia research advance more. Here, we present an open dataset of 33 fibromyalgia female patients and 33 paired healthy controls recruited from a Mexican population. Dataset includes demographic, clinical, behavioural and magnetic resonance imaging (MRI) data. The MRI data consists of: structural (T1- and T2- weighted) and functional (task-based and resting state) sequences. The task was an emotion processing and regulation task based on visual stimuli. The MRI data contained in the repository are unprocessed, presented in Brain Imaging Data Structure (BIDS) format and available on the OpenNeuro platform for future analysis.

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Neural basis of positive and negative emotion regulation in remitted depression

Cited by 15 publications

References 129 publications

Abnormal global signal topography of self modulates emotion dysregulation in major depressive disorder

Abnormal global signal topography of self modulates emotion dysregulation in major depressive disorder

Common And Distinct Patterns Of Task-Related Neural Activation Abnormalities In Patients With Remitted And Current Major Depressive Disorder: A Systematic Review And Coordinate-Based Meta-Analysis

A behavioral and brain imaging dataset with focus on emotion regulation of women with fibromyalgia

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