Neural basis of alertness and cognitive performance impairments during sleepiness II. Effects of 48 and 72 h of sleep deprivation on waking human regional brain activity

Thomas, Maria; Sing, Helen C.; Belenky, Gregory; Holcomb, Henry H.; Mayberg, Helen S.; Dannals, Robert F.; Wagner, Henry N.; Thorne, David R.; Popp, Kathryn A.; Rowland, Laura M.; Welsh, Amy B.; Balwinski, Sharon M.; Redmond, Daniel P.

doi:10.1016/s1472-9288(03)00020-7

Cited by 60 publications

(73 citation statements)

References 103 publications

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“…Work effectiveness decreases during sleep deprivation at consecutive experimental sessions, but also at a single session if the tasks are repetitious and monotonous. Wellrested individuals can obtain similar results in a number of tests in a row, whereas during sleep-deprivation, the accuracy of performance deteriorates with consecutive tasks in a particular series [59]. As reported in literature, onenight sleep deprivation contributed to a 20-32% increase in the number of errors and a 14% increase in the time required to perform an electrocoagulation trial on a surgical laparoscope simulator [66,67].…”

Section: Post-deprivation Recovery: Rebound Sleepsupporting

confidence: 59%

“…The number of visual errors and hallucinations increases with the duration of wakefulness. Interestingly, the number of auditory errors does not increase significantly even after 72 hours of sleeplessness [59]. After 24 hours of sleep deprivation, the ability to distinguish scents deteriorates.…”

Section: Dermal Effectsmentioning

confidence: 93%

“…As reported in literature, onenight sleep deprivation contributed to a 20-32% increase in the number of errors and a 14% increase in the time required to perform an electrocoagulation trial on a surgical laparoscope simulator [66,67]. It is plausible that during a real surgical operation, the surgeon's motivation partially compensates for the effects of weariness [59]. Nonetheless, the problem of insufficient rest among the health care workers seems to have been underestimated.…”

Section: Post-deprivation Recovery: Rebound Sleepmentioning

confidence: 94%

“…Exteroceptive impairments Sleep loss results in inaccurate image formation on the retina and, as a consequence, the perceived images become dim, and double vision and the disruption of visual perception may occur [59]. Visual disruption initially results in the tunnel vision [60], but may affect the centre of the visual field as well, if the period of sleep deprivation is long [61,62].…”

Section: Dermal Effectsmentioning

confidence: 99%

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Consequences of sleep deprivation

Orzeł-Gryglewska¹

2010

International Journal of Occupational Medicine and Environmental Health

210

133

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This paper presents the history of research and the results of recent studies on the effects of sleep deprivation in animals and humans. Humans can bear several days of continuous sleeplessness, experiencing deterioration in wellbeing and effectiveness; however, also a shorter reduction in the sleep time may lead to deteriorated functioning. Sleeplessness accounts for impaired perception, difficulties in keeping concentration, vision disturbances, slower reactions, as well as the appearance of microepisodes of sleep during wakefulness which lead to lower capabilities and efficiency of task performance and to increased number of errors. Sleep deprivation results in poor memorizing, schematic thinking, which yields wrong decisions, and emotional disturbances such as deteriorated interpersonal responses and increased aggressiveness. The symptoms are accompanied by brain tissue hypometabolism, particularly in the thalamus, prefrontal, frontal and occipital cortex and motor speech centres. Sleep deficiency intensifies muscle tonus and coexisting tremor, speech performance becomes monotonous and unclear, and sensitivity to pain is higher. Sleeplessness also relates to the changes in the immune response and the pattern of hormonal secretion, of the growth hormone in particular. The risk of obesity, diabetes and cardiovascular disease increases. The impairment of performance which is caused by 20-25 hours of sleeplessness is comparable to that after ethanol intoxication at the level of 0.10% blood alcohol concentration. The consequences of chronic sleep reduction or a shallow sleep repeated for several days tend to accumulate and resemble the effects of acute sleep deprivation lasting several dozen hours. At work, such effects hinder proper performance of many essential tasks and in extreme situations (machine operation or vehicle driving), sleep loss may be hazardous to the worker and his/her environment.

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Section: Post-deprivation Recovery: Rebound Sleepsupporting

confidence: 59%

Section: Dermal Effectsmentioning

confidence: 93%

Section: Post-deprivation Recovery: Rebound Sleepmentioning

confidence: 94%

Section: Dermal Effectsmentioning

confidence: 99%

See 2 more Smart Citations

Consequences of sleep deprivation

Orzeł-Gryglewska¹

2010

International Journal of Occupational Medicine and Environmental Health

210

133

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“…An important corollary of this hypothesis is that an increase in synaptic density should boost the metabolic cost of brain function, because the majority of that cost originates in the synapses (for a recent review see Raichle and Mintun 2006). Despite an extant literature on quantitative measures of brain circulation and metabolism in relation to sleep in humans (Andersson et al 1998;Boyle et al 1994;Braun et al 1997;Buchsbaum et al 1989;Madsen et al 1991aMadsen et al , 1991bMangold et al 1955;Thomas et al 2003) and laboratory animals (Kennedy et al 1976;Reivich et al 1968;Vyazovskiy et al 2008), an adequate test of this cost-based hypothesis remains to be done.…”

mentioning

confidence: 99%

Morning-evening variation in human brain metabolism and memory circuits

Shannon

Dosenbach

et al. 2013

Journal of Neurophysiology

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Prior LJ, Nolan TS, Snyder AZ, Raichle ME. Morning-evening variation in human brain metabolism and memory circuits. J Neurophysiol 109: 1444 -1456, 2013. First published November 28, 2012 doi:10.1152/jn.00651.2012.-It has been posited that a critical function of sleep is synaptic renormalization following a net increase in synaptic strength during wake. We hypothesized that wake would alter the resting-state functional organization of the brain and increase its metabolic cost. To test these hypotheses, two experiments were performed. In one, we obtained morning and evening resting-state functional MRI scans to assess changes in functional brain organization. In the second experiment, we obtained quantitative positron emission tomography measures of glucose and oxygen consumption to assess the cost of wake. We found selective changes in brain organization. Most prominently, bilateral medial temporal regions were locally connected in the morning but in the evening exhibited strong correlations with frontal and parietal brain regions involved in memory retrieval. We speculate that these changes may reflect aspects of memory consolidation recurring on a daily basis. Surprisingly, these changes in brain organization occurred without increases in brain metabolism.

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Making group inferences using sparse representation of resting-state functional mRI data with application to sleep deprivation

Shen

Wang

et al. 2017

Hum. Brain Mapp.

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Past studies on drawing group inferences for functional magnetic resonance imaging (fMRI) data usually assume that a brain region is involved in only one functional brain network. However, recent evidence has demonstrated that some brain regions might simultaneously participate in multiple functional networks. Here, we presented a novel approach for making group inferences using sparse representation of resting-state fMRI data and its application to the identification of changes in functional networks in the brains of 37 healthy young adult participants after 36 h of sleep deprivation (SD) in contrast to the rested wakefulness (RW) stage. Our analysis based on group-level sparse representation revealed that multiple functional networks involved in memory, emotion, attention, and vigilance processing were impaired by SD. Of particular interest, the thalamus was observed to contribute to multiple functional networks in which differentiated response patterns were exhibited. These results not only further elucidate the impact of SD on brain function but also demonstrate the ability of the proposed approach to provide new insights into the functional organization of the resting-state brain by permitting spatial overlap between networks and facilitating the description of the varied relationships of the overlapping regions with other regions of the brain in the context of different functional systems. Hum Brain Mapp 38:4671-4689, 2017. © 2017 Wiley Periodicals, Inc.

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Neural basis of alertness and cognitive performance impairments during sleepiness II. Effects of 48 and 72 h of sleep deprivation on waking human regional brain activity

Cited by 60 publications

References 103 publications

Consequences of sleep deprivation

Consequences of sleep deprivation

Morning-evening variation in human brain metabolism and memory circuits

Making group inferences using sparse representation of resting-state functional mRI data with application to sleep deprivation

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