Neural bases of different cognitive strategies for facial affect processing in schizophrenia

Fakra, É.; Salgado‐Pineda, Pilar; Delaveau, Pauline; Hariri, Ahmad R.; Blin, Olivier

doi:10.1016/j.schres.2007.11.040

Cited by 124 publications

(102 citation statements)

References 73 publications

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“…This decreased or "less efficient" connectivity is analogous to the reductions in connectivity between regions implicated in aggression in anger-prone individuals (Passamonti et al, 2008) and to the more extreme finding of absent connectivity in psychiatric disorders of aggression (Coccaro et al, 2007), generalized anxiety (Monk et al, 2008), schizophrenia (Fakra et al, 2008), and antisocial behavior (Marsh et al, 2008). Together, these findings provide evidence that less efficient connectivity among relevant brain regions might represent Figure 5.…”

Section: Implications For Obesity Researchmentioning

confidence: 68%

Personality Predicts the Brain's Response to Viewing Appetizing Foods: The Neural Basis of a Risk Factor for Overeating

Passamonti¹,

Rowe²,

Schwarzbauer³

et al. 2009

J. Neurosci.

117

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Eating is not only triggered by hunger but also by the sight of foods. Viewing appetizing foods alone can induce food craving and eating, although there is considerable variation in this "external food sensitivity" (EFS). Because increased EFS is associated with overeating, identifying its neural correlates is important for understanding the current epidemic of obesity. Animal research has identified the ventral striatum, amygdala, hypothalamus, medial prefrontal and premotor cortices as key interacting structures for feeding. However, it is unclear whether a similar network exists in humans and how it is affected by EFS. Using functional magnetic resonance imaging, we showed that viewing appetizing compared with bland foods produced changes in connectivity among the human ventral striatum, amygdala, anterior cingulate and premotor cortex that were strongly correlated with EFS. Differences in the dynamic interactions within the human appetitive network in response to pictures of appetizing foods may determine an individual's risk of obesity.

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Section: Implications For Obesity Researchmentioning

confidence: 68%

Personality Predicts the Brain's Response to Viewing Appetizing Foods: The Neural Basis of a Risk Factor for Overeating

Passamonti¹,

Rowe²,

Schwarzbauer³

et al. 2009

J. Neurosci.

117

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show abstract

“…Behaviourally, the only notable group difference found across studies employing non-facial baseline conditions was a slowed response in patients [42,47,49,[54][55][56], although one study found patients to be less accurate than controls at identifying all emotions[41].…”

Section: Findings For An Attentional Bias Towards Negative Stimuli Inmentioning

confidence: 99%

Psychobiology of threat appraisal in the context of psychotic experiences: A selective review

2015

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A key factor in the transition to psychosis is the appraisal of anomalous experiences as threatening.Cognitive models of psychosis have identified attentional and interpretative biases underlying threatbased appraisals. While much research has been conducted into these biases within the clinical and cognitive literature, little examination has occurred at the neural level. However, neurobiological research in social cognition employing threatening stimuli mirror cognitive accounts of maladaptive appraisal in psychosis. This review attempted to integrate neuroimaging data regarding social cognition in psychosis with the concepts of attentional and interpretative threat biases. Systematic review methodology was used to identify relevant articles from Medline, PsycINFO and EMBASE, and PubMed databases. The selective review showed that attentional and interpretative threat biases relate to abnormal activation of a range of subcortical and prefrontal structures, including the amygdala, insula, hippocampus, anterior cingulate, and prefrontal cortex, as well as disrupted connectivity between these regions, when processing threatening and neutral or ambiguous stimuli.Notably, neural findings regarding the misattribution of threat to neutral or ambiguous stimuli presented a more consistent picture. Overall, however, the findings for any specific emotion were mixed, both in terms of the specific brain areas involved and the direction of effects (increased/decreased activity), possibly owing to confounds including small sample sizes, varying experimental paradigms, medication, and heterogeneous, in some cases poorly characterised, patient groups. Further neuroimaging research examining these biases by employing experimentally-induced anomalous perceptual experiences and well-characterised large samples is needed for greater aetiological specificity.

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“…4,5 The neural substrates of facial affect recognition in schizophrenia are also unclear, notably for the activity of the amygdala, a crucial brain nucleus implicated in emotional processes. Whereas the majority of neuroimaging studies in schizophrenia have demonstrated decreases in amygdala activity, [6][7][8][9][10][11][12][13] 2 studies have shown an increased response of the right amygdala to happy, 14 fearful and neutral faces. 15 These differences across different studies may be related to differences in symptomatology and the medications used.…”

Section: Introductionmentioning

confidence: 99%

“…14,15 We believe that a heightened automatic emotional response could interfere with basic emotional processing and subsequently require compensatory strategies to make emotional judgments. We have shown in a previous study 6 that, during performance of an emotional recognition task, patients with schizophrenia resort to alternative cognitive strategies consisting of the use of a feature-based analysis to identify facial emotions, implying deactivation of amygdala. Our objective in the present study was to test the hypothesis that schizophrenia patients show a shift in their amygdala response during emotional tasks (i.e., initially normal amygdala activity followed by a decrease).…”

Section: Introductionmentioning

confidence: 99%

Differential patterns of initial and sustained responses in amygdala and cortical regions to emotional stimuli in schizophrenia patients and healthy participants

Salgado‐Pineda

Fakra

Delaveau

et al. 2010

jpn

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41Background: We sought to investigate the altered brain responses to emotional stimuli in patients with schizophrenia. Methods: We ana lyzed data from 14 patients with schizophrenia and 14 healthy controls who performed an emotional face matching task. We evaluated brain activity and connectivity in the amygdala and cortical regions during the initial (first 21 seconds of each stimulation block) and sustained (last 21 seconds) stages of an emotional processing task, and we determined changes in amygdala activity across the emotional processing task. Results: The patients with schizophrenia showed similar amygdala activation to the controls during the initial stage of processing, but their activation decreased during the sustained stage. The controls showed increasing amygdala activity across the emotional blocks, whereas activity progressively decreased in the schizophrenia group. The patients with schizophrenia showed increased cortical activity and interconnectivity in the medial frontal and inferior parietal cortex in the initial stage of emotional processing. There was increased activity in the superior temporal cortex and greater connectivity with the inferior parietal cortex in the sustained stage. Performance accuracy was lower in the schizophrenia group in the first part of the block, while their reaction time was longer in the latter part of the block. Limitations: It was not possible to specify the moment at which the switch in amygdala response occurred. Conclusion: Our findings suggest that patients with schizophrenia have an initial automatic emotional response but that they need to switch to a compensatory cognitive strategy to solve the task.

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Neural bases of different cognitive strategies for facial affect processing in schizophrenia

Cited by 124 publications

References 73 publications

Personality Predicts the Brain's Response to Viewing Appetizing Foods: The Neural Basis of a Risk Factor for Overeating

Personality Predicts the Brain's Response to Viewing Appetizing Foods: The Neural Basis of a Risk Factor for Overeating

Psychobiology of threat appraisal in the context of psychotic experiences: A selective review

Differential patterns of initial and sustained responses in amygdala and cortical regions to emotional stimuli in schizophrenia patients and healthy participants

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