The most intense rhythm of brain maturation in humans occurs in early childhoodthe period between zero and 5 years of age. Such significant structural or functional development is not observed at any other homologous period throughout the lifespan. From a simple tubular structure in the foetal period (the neural tube), in a few years the brain develops a highly complex cytoarchitecture (Dubois et al., 2021;Ouyang et al., 2019). Its size also increases significantly, with the brain of a 6-year-old having nearly the volume (95%) of the adult brain (Lenroot & Giedd, 2006). In addition, early childhood is the most productive period in creating new synapses -for example, reaching 15,000 connections per neuron between 2-3 years of age -twice as many as the amount observed in adults (Huttenlocher, 1979).Brain metabolism also peaks at 200% of the adult pattern at about 4 years of age (Chugani, 1998). These maturational phenomena are the foundation of a child's physical and mental health, determining longevity and the ability to learn from contextual changes and adapt to them (Cruz et al., 2020;Sampaio & Lifter, 2014). In turn, these phenomena are influenced by an array of genetic and environmental factors. As described by the National Scientific Council