Neural and glial damage markers in women after long-term weight-recovery from anorexia nervosa

Doose, Arne; Hellerhoff, Inger; Tam, Friederike I.; King, Joseph A.; Seidel, Maria; Geisler, Daniel; Plähn, Hans Christian I.; Roessner, Veit; Akgün, Katja; Ziemssen, Tjalf; Ehrlich, Stefan

doi:10.1016/j.psyneuen.2021.105576

Cited by 7 publications

(6 citation statements)

References 35 publications

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“…With respect to the meaning of possible occipital differences, these do not represent brain areas associated with emotional and motivational processing, but visual processing and might be unspecific [ 43 ]. Finally, we point to a recent report on neurobiological markers of 55 REC, which did not find differences between NP and REC, which can be regarded as a complementary finding to our results [ 71 ].…”

Section: Discussionsupporting

confidence: 87%

“…Not only neuronal and glial damage appear to be state phenomena [ 4 , 71 ] but, according to our results, neural processing and affective rating of food stimuli also seem to be state-related. Certain neuropsychological characteristics seem to persist in some patients with AN after clinical recovery, such as difficulties in set-shifting abilities and weaker central coherence [ 72 ].…”

Section: Discussionsupporting

confidence: 65%

“…In summary, similar to the restitution of structural cerebral abnormalities [ 5 , 20 ] and serum neuronal biomarkers [ 71 ], functional brain aberrations also seem to be a state phenomenon , at least in terms of processing of food stimuli. However, this should be proven experimentally by longitudinal studies in AN and larger cohorts, which is not easily feasible methodically.…”

Section: Discussionmentioning

confidence: 80%

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State or trait: the neurobiology of anorexia nervosa — contributions of a functional magnetic resonance imaging study

et al. 2022

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Background The understanding of the cerebral neurobiology of anorexia nervosa (AN) with respect to state- versus trait-related abnormalities is limited. There is evidence of restitution of structural brain alterations with clinical remission. However, with regard to functional brain abnormalities, this issue has not yet been clarified. Methods We compared women with AN (n = 31), well-recovered female participants (REC) (n = 18) and non-patients (NP) (n = 27) cross-sectionally. Functional magnetic resonance imaging was performed to compare neural responses to food versus non-food images. Additionally, affective ratings were assessed. Results Functional responses and affective ratings did not differ between REC and NP, even when applying lenient thresholds for the comparison of neural responses. Comparing REC and AN, the latter showed lower valence and higher arousal ratings for food stimuli, and neural responses differed with lenient thresholds in an occipital region. Conclusions The data are in line with some previous findings and suggest restitution of cerebral function with clinical recovery. Furthermore, affective ratings did not differ from NP. These results need to be verified in intra-individual longitudinal studies.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 80%

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State or trait: the neurobiology of anorexia nervosa — contributions of a functional magnetic resonance imaging study

et al. 2022

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“…Elevated Nf levels are present too little (Wentz et al, 2020) and too much nourishment (Beydoun et al, 2021; Manouchehrinia, Piehl, et al, 2020). The longitudinal concentration of Nf normalised with successful regain of weight (Doose et al, 2021). Related to at least diabetes mellitus, an association was found between elevated serum NfL levels that were predictive of all‐cause mortality in women (Beydoun et al, 2022).…”

Section: Diseasesmentioning

confidence: 99%

The 2022 Lady Estelle Wolfson lectureship on neurofilaments

Petzold

2022

Journal of Neurochemistry

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Neurofilament proteins (Nf) have been validated and established as a reliable body fluid biomarker for neurodegenerative pathology. This review covers seven Nf isoforms, Nf light (NfL), two splicing variants of Nf medium (NfM), two splicing variants of Nf heavy (NfH), -internexin (INA) and peripherin (PRPH). The genetic and epigenetic aspects of Nf are discussed as relevant for neurodegenerative diseases and oncology. The comprehensive list of mutations for all Nf isoforms covers Amyotrophic Lateral Sclerosis, Charcot-Marie Tooth disease, Spinal muscular atrophy, Parkinson Disease and Lewy Body Dementia. Next, emphasis is given to the expanding field of post-translational modifications (PTM) of the Nf amino acid residues. Protein structural aspects are reviewed alongside PTMs causing neurodegenerative pathology and human autoimmunity. Molecular visualisations of NF PTMs, assembly and stoichiometry make use of Alphafold2 modelling. The implications for Nf function on the cellular level and axonal transport are discussed. Neurofilament aggregate formation and proteolytic breakdown are reviewed as relevant for biomarker tests and disease.Likewise, Nf stoichiometry is reviewed with regard to in vitro experiments and as a compensatory mechanism in neurodegeneration. The review of Nf across a spectrum of 87 diseases from all parts of medicine is followed by a critical appraisal of 33

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“…To test this hypothesis with in-vivo measurements, several studies have therefore investigated blood markers of brain damage (Doose et al, 2021 ; Hellerhoff et al, 2021 ; Nilsson et al, 2019 ; Wentz et al, 2021 ). These markers provide information about specific processes on a cellular level (Zetterberg, Smith, & Blennow, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Serum neurofilament light concentrations are associated with cortical thinning in anorexia nervosa

et al. 2023

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Background Anorexia nervosa (AN) is characterized by severe emaciation and drastic reductions of brain mass, but the underlying mechanisms remain unclear. The present study investigated the putative association between the serum-based protein markers of brain damage neurofilament light (NF-L), tau protein, and glial fibrillary acidic protein (GFAP) and cortical thinning in acute AN. Methods Blood samples and magnetic resonance imaging scans were obtained from 52 predominantly adolescent, female patients with AN before and after partial weight restoration (increase in body mass index >14%). The effect of marker levels before weight gain and change in marker levels on cortical thickness (CT) was modeled at each vertex of the cortical surface using linear mixed-effect models. To test whether the observed effects were specific to AN, follow-up analyses exploring a potential general association of marker levels with CT were conducted in a female healthy control (HC) sample (n = 147). Results In AN, higher baseline levels of NF-L, an established marker of axonal damage, were associated with lower CT in several regions, with the most prominent clusters located in bilateral temporal lobes. Tau protein and GFAP were not associated with CT. In HC, no associations between damage marker levels and CT were detected. Conclusions A speculative interpretation would be that cortical thinning in acute AN might be at least partially a result of axonal damage processes. Further studies should thus test the potential of serum NF-L to become a reliable, low-cost and minimally invasive marker of structural brain alterations in AN.

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Neural and glial damage markers in women after long-term weight-recovery from anorexia nervosa

Cited by 7 publications

References 35 publications

State or trait: the neurobiology of anorexia nervosa — contributions of a functional magnetic resonance imaging study

State or trait: the neurobiology of anorexia nervosa — contributions of a functional magnetic resonance imaging study

The 2022 Lady Estelle Wolfson lectureship on neurofilaments

Serum neurofilament light concentrations are associated with cortical thinning in anorexia nervosa

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