Neural and Cognitive Factors Influencing the Emergence of Psychopathology: Insights From the Bucharest Early Intervention Project

Troller‐Renfree, Sonya V.; Zeanah, Charles H.; Nelson, Charles A.

doi:10.1111/cdep.12251

Cited by 23 publications

(15 citation statements)

References 46 publications

(55 reference statements)

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“…Other disorders, more on the externalizing spectrum, like SUD or pathological gambling, might fit more with the framework of underregulation, as those disorders appear to reflect a failure to exert self-control when needed (Luijten et al, 2014 ). Consistent with our present findings, externalizing disorders (including a general aggressive disposition) have been associated with lower ERN amplitudes (Troller-Renfree et al, 2018 ; Grisetto et al, 2019 ; Pasion and Barbosa, 2019 ).…”

Section: Discussionsupporting

confidence: 92%

The Error-Related Negativity Predicts Self-Control Failures in Daily Life

Overmeyer

Berghäuser

Dieterich

et al. 2021

Front. Hum. Neurosci.

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Adaptive behavior critically depends on performance monitoring (PM), the ability to monitor action outcomes and the need to adapt behavior. PM-related brain activity has been linked to guiding decisions about whether action adaptation is warranted. The present study examined whether PM-related brain activity in a flanker task, as measured by electroencephalography (EEG), was associated with adaptive behavior in daily life. Specifically, we were interested in the employment of self-control, operationalized as self-control failures (SCFs), and measured using ecological momentary assessment. Analyses were conducted using an adaptive elastic net regression to predict SCFs from EEG in a sample of 131 participants. The model was fit using within-subject averaged response-locked EEG activity at each electrode and time point within an epoch surrounding the response. We found that higher amplitudes of the error-related negativity (ERN) were related to fewer SCFs. This suggests that lower error-related activity may relate to lower recruitment of interventive self-control in daily life. Altered cognitive control processes, like PM, have been proposed as underlying mechanisms for various mental disorders. Understanding how alterations in PM relate to regulatory control might therefore aid in delineating how these alterations contribute to different psychopathologies.

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Section: Discussionsupporting

confidence: 92%

The Error-Related Negativity Predicts Self-Control Failures in Daily Life

Overmeyer

Berghäuser

Dieterich

et al. 2021

Front. Hum. Neurosci.

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“…McDermott and colleagues, as well as Grammer and colleagues (Grammer et al, 2014;Lamm et al, 2014;Troller-Renfree, Zeanah, Nelson, & Fox, 2018), enabled us to maximize the child's ability to be engaged during the EEG/ERP session allowing us to more effectively examine error-related ERPs and time-frequency data in our sample. Second, researchers should note that because time-frequency analyses allow for extraction of power within specific ranges (e.g.…”

Section: Discussionmentioning

confidence: 99%

Neural Dynamics of Executive Function in Cognitively-able Kindergarteners with Autism Spectrum Disorders (ASD) as Predictors of Concurrent Academic Achievement

Kim

Buzzell

Faja

et al. 2018

Preprint

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Although electrophysiological (EEG) measures of executive functions (EF) (e.g. error monitoring) have been used to predict academic achievement in typically developing (TD) children, work investigating a link between error monitoring, and academic skills in children with autism spectrum disorder (ASD) is limited. In the current study, we employed traditional electrophysiological and advanced time-frequency methods, combined with principal components analyses, to extract neural activity related to error monitoring, and tested their relations to academic achievement in cognitively-able kindergarteners with ASD. Thirty-five cognitively-able kindergarteners with ASD completed academic assessments and the childfriendly "Zoo Game" Go/No-go task at school entry. The Go/No-go task successfully elicited an error-related negativity (ERN) and error positivity (Pe) in children with ASD as young as 5 years at medio-frontal and posterior electrode sites, respectively. We also observed increased responserelated theta power during errors relative to correct trials at medio-frontal sites. Both larger Pe and theta power significantly predicted concurrent academic achievement after controlling for behavioral performance on the Zoo Game and IQ. These results suggest that the use of time frequency EEG analyses, combined with traditional ERP measures, may provide new opportunities to investigate neurobiological mechanisms of EF and academic achievement in young children with ASD.

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“…For example, children who grow up in low socioeconomic status have altered immune function [111], are often exposed to more environmental toxicants [112], suffer poor nutrition [113], and are exposed to various psychosocial stressors [114]. Similarly, children who experience institutionalization are affected by a pervasive mixture of these elements [111,115,116,117]. While the animal models reviewed in previous sections have helped us understand how prenatal immune challenges, toxicant exposure, dietary factors, and early-life stress can each affect brain and behavior, future studies are certainly warranted that incorporate multiple factors to help elucidate how factors act in conjunction to influence development.…”

Section: Concluding Remarks and Recommendations For Future Researchmentioning

confidence: 99%

Animal Models and Their Contribution to Our Understanding of the Relationship Between Environments, Epigenetic Modifications, and Behavior

Phillips

Roth

2019

Genes

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The use of non-human animals in research is a longstanding practice to help us understand and improve human biology and health. Animal models allow researchers, for example, to carefully manipulate environmental factors in order to understand how they contribute to development, behavior, and health. In the field of behavioral epigenetics such approaches have contributed novel findings of how the environment physically interacts with our genes, leading to changes in behavior and health. This review highlights some of this research, focused on prenatal immune challenges, environmental toxicants, diet, and early-life stress. In conjunction, we also discuss why animal models were integral to these discoveries and the translational relevance of these discoveries.

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Neural and Cognitive Factors Influencing the Emergence of Psychopathology: Insights From the Bucharest Early Intervention Project

Cited by 23 publications

References 46 publications

The Error-Related Negativity Predicts Self-Control Failures in Daily Life

The Error-Related Negativity Predicts Self-Control Failures in Daily Life

Neural Dynamics of Executive Function in Cognitively-able Kindergarteners with Autism Spectrum Disorders (ASD) as Predictors of Concurrent Academic Achievement

Animal Models and Their Contribution to Our Understanding of the Relationship Between Environments, Epigenetic Modifications, and Behavior

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