Neural and behavioral measures suggest that cognitive and affective functioning interactions mediate risk for psychosis‐proneness symptoms in youth with chromosome 22q11.2 deletion syndrome

Abstract

Behavioral components of chromosome 22q11.2 deletion syndrome (22q), caused by the most common human microdeletion, include cognitive and adaptive functioning impairments, heightened anxiety, and an elevated risk of schizophrenia. We investigated how interactions between executive function and the largely overlooked factor of emotion regulation might relate to the incidence of symptoms of psychotic thinking in youth with 22q. We measured neural activity with event-related potentials (ERPs) in variants of an inhibitory function (Go/No-Go) experimental paradigm that

Atypical response inhibition and error processing in 22q11.2 Deletion Syndrome and schizophrenia: Towards neuromarkers of disease progression and risk

“…However, no differences were found between 22q11.2DS and neurotypical controls, possibly reflecting the lack of a clear N2 effect in either group. In a recent study utilizing an affective Go/No-Go task, adolescents with 22q11.2DS presented different N2 amplitudes when compared to their neurotypical peers, but only for emotionally salient stimuli (angry and happy facial expressions) ( Linton et al, 2020 ). Here, we did not present any negative valence stimuli or, specifically, facial expressions.…”

Source‐based morphometry reveals structural brain pattern abnormalities in 22q11.2 deletion syndrome

“…22q11.2 deletion syndrome (22q11DS) is the most commonly occurring microdeletion in humans, affecting an estimated 1 in 2000 to 4000 newborns (Blagojevic et al, 2021; McDonald‐McGinn et al, 2015). In addition to the congenital cardiovascular and craniofacial anomalies that most often lead to diagnosis, the vast majority of individuals with 22q11DS also exhibit anomalies related to the central nervous system (CNS) (Blagojevic et al, 2021; Hopkins et al, 2018; Linton et al, 2020; McDonald‐McGinn et al, 2015). The most prevalent CNS anomalies encompass a spectrum of intellectual and learning disabilities or cognitive deficits (>90%), psychiatric disorders (60%; estimated 25–30% with psychotic illness), and combinations thereof (Linton et al, 2020; Moberg et al, 2018).…”