Neural activity induces strongly coupled electro-chemo-mechanical interactions and fluid flow in astrocyte networks and extracellular space – a computational study
Abstract:The complex interplay between chemical, electrical, and mechanical factors is fundamental to the function and homeostasis of the brain, but the effect of electrochemical gradients on brain interstitial fluid flow, solute transport, and clearance remains poorly quantified. Here, via in-silico experiments based on biophysical modeling, we estimate water movement across astrocyte cell membranes, within astrocyte networks, and within the extracellular space (ECS) induced by neuronal activity, and quantify the rela… Show more
“… 133 The recent revelation of the glymphatic system has notably enhanced our comprehension of fluid dynamics in the CNS. 134 Deeper insights into neurovascular coupling mechanisms 135 and the pivotal role of astrocytes in ECS homeostasis 136 contribute to a holistic understanding. The implications extend to neurological disorders, with ECS dysregulation implicated in conditions such as epilepsy and neurodegenerative diseases.…”
The delivery of genes to the central nervous system (CNS) has been a persistent challenge due to various biological barriers. The blood-brain barrier (BBB), in particular, hampers the access of...
“… 133 The recent revelation of the glymphatic system has notably enhanced our comprehension of fluid dynamics in the CNS. 134 Deeper insights into neurovascular coupling mechanisms 135 and the pivotal role of astrocytes in ECS homeostasis 136 contribute to a holistic understanding. The implications extend to neurological disorders, with ECS dysregulation implicated in conditions such as epilepsy and neurodegenerative diseases.…”
The delivery of genes to the central nervous system (CNS) has been a persistent challenge due to various biological barriers. The blood-brain barrier (BBB), in particular, hampers the access of...
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