Neural activity in the social decision-making network of the brown anole during reproductive and agonistic encounters

Kabelik, David; Weitekamp, Chelsea A.; Choudhury, Shelley C.; Hartline, Jacob T.; Smith, Alexandra N.; Hofmann, Hans A.

doi:10.1016/j.yhbeh.2018.06.013

Cited by 27 publications

(25 citation statements)

References 37 publications

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“…The results of this study demonstrate an additional conserved organizational principle between vertebrate and invertebrate brains [28], and validate theoretical considerations regarding the partitioning of valenced information to different subregions of a tiny brain [15,75]. Recently, IEG mapping has implicated nodes of the vertebrate social decision-making network (SDMN [76]) that are differentially sensitive to aggressive encounters compared to reproductive attempts in brown anoles [77], and a similar segregation of positive and negative valence was found in songbirds [32]. While no SDMN has been proposed for invertebrates, our findings point to a similar system in invertebrate brains, which awaits further elucidation.…”

Section: Discussionsupporting

confidence: 70%

Valence of social information is encoded in different subpopulations of mushroom body Kenyon cells in the honeybee brain

et al. 2019

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Over 600 Myr of evolutionary divergence between vertebrates and invertebrates is associated with considerable neuroanatomical variation both across and within these lineages. By contrast, valence encoding is an important behavioural trait that is evolutionarily conserved across vertebrates and invertebrates, and enables individuals to distinguish between positive (potentially beneficial) and negative (potentially harmful) situations. We tested the hypothesis that social interactions of positive and negative valence are modularly encoded in the honeybee brain (i.e. encoded in different cellular subpopulations) as in vertebrate brains. In vertebrates, neural activation patterns are distributed across distinct parts of the brain, suggesting that discrete circuits encode positive or negative stimuli. Evidence for this hypothesis would suggest a deep homology of neural organization between insects and vertebrates for valence encoding, despite vastly different brain sizes. Alternatively, overlapping localization of valenced social information in the brain would imply a ‘re-use' of circuitry in response to positive and negative social contexts, potentially to overcome the energetic constraints of a tiny brain. We used immediate early gene expression to map positively and negatively valenced social interactions in the brain of the western honeybee Apis mellifera . We found that the valence of a social signal is represented by distinct anatomical subregions of the mushroom bodies, an invertebrate sensory neuropil associated with social behaviour, multimodal sensory integration, learning and memory. Our results suggest that the modularization of valenced social information in the brain is a fundamental property of neuroanatomical organization.

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Section: Discussionsupporting

confidence: 70%

Valence of social information is encoded in different subpopulations of mushroom body Kenyon cells in the honeybee brain

et al. 2019

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“…Thus, it has been hypothesized that immediate early genes can be the molecular first responders to perceived changes in the social environment that trigger subsequent changes in the neurogenomic state of the SDMN that allows the animal to adjust its behavioral state accordingly (Cardoso et al, 2015). Several studies have documented changes in immediate early gene (IEG) expression across the SDMN associated with changes in social behavior across different vertebrate taxa (e.g., Faykoo-Martinez et al, 2018;Kabelik et al, 2018;O'Connell and Hofmann, 2012), including teleost fish and also tilapia (e.g., Field and Maruska, 2017;Roleira et al, 2017;Teles et al, 2015). In particular, changes in social status (i.e., ascending or descending in a social hierarchy) have been associated with rapid changes in IEG expression in the SDMN paralleled by changes in social behavior (Maruska et al, 2013a,b;Teles et al, 2015;Williamson et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

How to Improve the YLS/CMI? Exploring a Particularly Predictive Combination of Items

Villanueva

Basto-Pereira

Cuervo

2019

Int J Offender Ther Comp Criminol

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Recidivism risk assessment is central to addressing criminogenic needs among youth offenders. To accomplish this, the Youth Level of Service/Case Management Inventory (YLS/CMI) is worldwide used, but it is long and has limited predictive validity for minority populations. This study presents a particularly predictive combination of seven items that overcomes these limitations. A sample of 430 Spanish youth offenders participated in this study. The YLS/CMI long version was filled out and reconvictions were collected over a 2-year period. Results show that this combination of seven items reduced more than 80% of the inventory and improved the predictive validity, globally and for minorities. The items that were included were related to psychopathic traits and the lack of protective role models. Therefore, this specific combination of YLS/CMI items has considerable higher predictive validity across gender and culture, and may be useful to practitioners in this field.

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“…We measured baseline gene expression in bold and shy individuals across six brain regions that contribute to social decision-making and are functionally conserved across vertebrates (Kabelik et al, 2018; Newman, 1999; O’Connell and Hofmann, 2011, 2012; Thompson et al, 2008; Walton et al, 2010) ( Figure 2A ; Supplemental Excel File). The number of differentially expressed genes across brain regions were relatively few (average of 8), with the exception of the ventromedial hypothalamus, where 608 genes were differentially expressed.…”

Section: Resultsmentioning

confidence: 99%

“…Among vertebrates, the lack of understanding of neuroendocrine regulators of behavioral phenotypes is especially true among non-avian reptiles, as they are the least studied vertebrate taxonomic group (Kabelik and Hofmann, 2018), despite serving as an important evolutionary comparison group, especially for amniotic vertebrates. A social decision-making network has been described in reptiles (Kabelik et al, 2018), and various neuroendocrine variables have been related to the expression of social behaviors in lizards (Dunham and Wilczynski, 2014; Hartline et al, 2017; Kabelik et al, 2013, 2008b; Kabelik and Crews, 2017; Kabelik and Magruder, 2014; Korzan et al, 2001; Korzan and Summers, 2004; Larson and Summers, 2001; Smith and Kabelik, 2017; Watt et al, 2007; Sarah C. Woolley et al, 2004; Woolley et al, 2001; Sarah C Woolley et al, 2004). However, many potential regulators of social boldness remain unexamined.…”

Section: Introductionmentioning

confidence: 99%

Social boldness correlates with brain gene expression in male green anoles

Kabelik

Julien

Ramirez

et al. 2021

Preprint

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Within populations, some individuals tend to exhibit a bold or shy social behavior phenotype relative to the mean. The neural underpinnings of these differing phenotypes – also described as syndromes, personalities, and coping styles – is an area of ongoing investigation. Although a social decision-making network has been described across vertebrate taxa, most studies examining activity within this network do so in relation to exhibited differences in behavioral expression. Our study instead focuses on constitutive gene expression in bold and shy individuals by isolating baseline gene expression profiles that influence social boldness predisposition, rather than those reflecting the results of social interaction and behavioral execution. We performed this study on male green anole lizards (Anolis carolinensis), an established model organism for behavioral research, which provides a crucial comparison group to investigations of birds and mammals. After identifying subjects as bold or shy through repeated reproductive and agonistic behavior testing, we used RNA sequencing to compare gene expression profiles between these groups within various forebrain, midbrain, and hindbrain regions. The ventromedial hypothalamus had the largest group differences in gene expression, with bold males having increased expression of calcium channels and neuroendocrine receptor genes compared to shy males. Conversely, shy males express more integrin alpha-10 in the majority of examined regions. There were no significant group differences in physiology or hormone levels. Our results highlight the ventromedial hypothalamus as an important center of behavioral differences across individuals and provide novel candidates for investigation into the regulation of individual variation in social behavior phenotype.

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Neural activity in the social decision-making network of the brown anole during reproductive and agonistic encounters

Cited by 27 publications

References 37 publications

Valence of social information is encoded in different subpopulations of mushroom body Kenyon cells in the honeybee brain

Valence of social information is encoded in different subpopulations of mushroom body Kenyon cells in the honeybee brain

How to Improve the YLS/CMI? Exploring a Particularly Predictive Combination of Items

Social boldness correlates with brain gene expression in male green anoles

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