NeuM: A Neuron‐Selective Probe Incorporates into Live Neuronal Membranes via Enhanced Clathrin‐Mediated Endocytosis in Primary Neurons
Yoonsik Sung,
Lizaveta Gotina,
Kyu Hyeon Kim
et al.
Abstract:The development of a small‐molecule probe designed to selectively target neurons would enhance the exploration of intricate neuronal structures and functions. Among such probes, NeuO stands out as the pioneer and has gained significant traction in the field of research. Nevertheless, neither the mechanism behind neuron‐selectivity nor the cellular localization has been determined. Here, we introduce NeuM, a derivative of NeuO, designed to target neuronal cell membranes. Furthermore, we elucidate the mechanism … Show more
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