2013
DOI: 10.1007/s00393-012-1078-5
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Neues zur Pathogenese der Myositiden

Abstract: Idiopathic inflammatory myopathies (IIM) are chronic inflammatory diseases of muscle characterized by proximal muscle weakness. There are three main groups of diseases, dermatomyositis, polymyositis and inclusion body myositis. The muscle tissue is invaded by the humoral autoantibody producing immune system (B-cells) and by the cellular immune system with autoaggressive and inflammation modulating cells (e.g. dendritic cells, monocytes/macrophages, CD4 + and CD8 + T-cells and natural killer cells). The presenc… Show more

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Cited by 3 publications
(1 citation statement)
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“…It is known that the pathogenesis of IIMs involves strong interactions between dendritic cells, activated Th1 and Th17 cells, B cells, muscle cells, genes, and environmental factors [ 14 ]. The autoimmune origin is supported by derailed cellular and humoral immune processes [ 15 ]. Ethnic differences and the HLA-associations suggest that genetic factors may play a part in the pathomechanism [ 16 ].…”
Section: Introductionmentioning
confidence: 99%
“…It is known that the pathogenesis of IIMs involves strong interactions between dendritic cells, activated Th1 and Th17 cells, B cells, muscle cells, genes, and environmental factors [ 14 ]. The autoimmune origin is supported by derailed cellular and humoral immune processes [ 15 ]. Ethnic differences and the HLA-associations suggest that genetic factors may play a part in the pathomechanism [ 16 ].…”
Section: Introductionmentioning
confidence: 99%